Viral Drugs

Question 1

Acyclovir, Famcyclovir, Valaciclovir and Ganciclovir area all analogs of

Answer 1

Guanasine

*purine

Question 2

Acyclovir, Famcyclovir, Valaciclovir and Ganciclovir are all phosphorylated by Which enzyme of infected cells?

Answer 2

Thymine kinase

This enzyme is present with virally infected cells and phosphorylates Guanines to cause chain termnination

Question 3

Drug specific for CMV

Answer 3

Ganciclovir

Question 4

Inhibits neuraminidase of Influenza A and B

Answer 4

Oseltamivir

Zanamivir

Question 5

Mnemonic for Influenza Hemagluttin

Answer 5

H= Hello! or Hola!

Hemagluttin facilitates viral entry

Question 6

Mnemonic for Influenza Neuroaminadase

Answer 6

N = Nos Vemos!

Neurominadase facilitates release of progeny

Question 7

Acyclovir, Famcyclovir, Valaciclor are used to treat

Answer 7

HSV and VZV

Question 8

Use this toxic pyroFOSphate analog when the other meds won’t work

Answer 8

FOScarnet

Question 9

Inhibits both DNA and RNA polymerase

Answer 9

Foscarnet

Question 10

More potent than Foscarnet and only inhibits DNA polymerase

Answer 10

Cidofovir

Question 11

“Navirs” are what class?

Answer 11

Protease inhibitors

*Navir tease a protease

Question 12

The only integrase inhibitor

Answer 12

Raltegravir

Question 13

Describe HAART therapy

Answer 13

2 NRTIs + 1 of the following

• Protease inhibitor
• NNRTI
• Integrase inhibitor

Question 14

In general, protease inhibitors increase or decrease side effects?

Answer 14

Increase, but they also increase our ability to fight the virus.

Ex: HYPERglycemia, Diarrhea, HYPERlipidemia etc

Question 15

These drugs inhibit reverse transcriptase

Answer 15

NRTIs

Question 16

These are prodrugs that has to be (phosphorylated)activated and are a competitive inhibitor for nucleotide binding to reverse transcriptase

Answer 16

NRTIs

Question 17

These drugs can cause bone marrow suppression so must be given with GCSF and Erythropoeitin

*granulocyte colony stimulating factor

Answer 17

NRTIs

Question 18

These drugs bind directly to reverse transcriptase

Answer 18

NNRTIs

Delavirdine
Efavirenz
Nevirapine

Question 19

Increases Creatine kinase

Answer 19

Raltegravir

Question 20

HIV docking protein

Answer 20

gp120

Question 21

HIV transmembrane protein

Answer 21

gp41

Question 22

Fusion inhibitor that binds gp41

Answer 22

Enfuviritide

*smaller alphabet : smaller number protein

Question 23

Fusion inhibitor that binds gp120

Answer 23

Maraviroc

*larger alphabet : larger number protein

Question 24

Which interferon is useful in treating the following:

Chronic hepatitis B and C
Kaposi sarcoma
Hairy cell leukemia
Condyloma acuminatum
Renal cell carcinoma
Malignant melanoma

Answer 24

Interferon alpha

Question 25

Which interferon is useful in treating multiple sclerosis?

Answer 25

Interferon beta

Question 26

Which interferon in useful in treating Chronic granulomatous disease (CGD)?

Answer 26

Interferon gamma

Question 27

Triple therapy for HepC

Answer 27

1. Ribavirin
2. Simeprevir
3. Peginterferon alfa

Question 28

Inhibits HepC RNA polymerase and only need to be given with Ribavirin

Very expensive$$$$$

Answer 28

Sofosbuvir