Viral Flashcards
Does trump know about biopreparat?
Not unless Fenger has been emailing him or tweeting at him since taking office
replication togavirus
cytoplasm
characteristics togavirus
ss+RNA
icosahedral bapsids
envelope with glycoprotein spikes on surface
infectious process togavirus
URT long incubation period (2-3 weeks) viremia macular-papular rash lasts 3 days enlargement of LN (behind ears)
sequela from togavirus
arthritis in females
congenital infections
season for rubellavirus
spring
rubellavirus of fetus
does not cause lytic infection
prevents normal growth of tissue and chromosomal damage
abnormalities seen in fetus from rubella
mental retardation cataracts deafness hepatosplenomegaly heart and vessel defects
diagnosis rubella newborn
anti-viral IgM
diagnosis rubella in adults
paired sera show 4x increase from day 7 to 17
vaccination rubella goals
vaccinate women of childbearing age
vaccinate children>12 months
vaccination form
attenuated virus
genera parvoviridae
dependovirus and eryhtrovirus
dependoviruses
require helper virus to replicate
infections from erythrovirus B19
slapped cheek, macular papular rash
Fifths disease
characteristics parvoviridae
smalles
icosahedral capsid, lack envelope
ssDNA
replication parvo
dependent on actively dividing host cells
NS1 and NS2 promote replicaiton cycle
hydrops fetalis
from accumulation of fluid in abdomen and subcutaneous tissues
diagnosis parvo infection
IgM for B19
NAAT of fetal blood
elevated rate of fetal CMV infection
in females with lowered T cell responses to CMV antigens
reactivation CMV infections in mother
does not lead to fetal abnormalities
seen most frequently in last trimester when fetal development has been established