Viral Flashcards

1
Q

Does trump know about biopreparat?

A

Not unless Fenger has been emailing him or tweeting at him since taking office

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2
Q

replication togavirus

A

cytoplasm

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3
Q

characteristics togavirus

A

ss+RNA
icosahedral bapsids
envelope with glycoprotein spikes on surface

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4
Q

infectious process togavirus

A
URT
long incubation period (2-3 weeks)
viremia
macular-papular rash lasts 3 days 
enlargement of LN (behind ears)
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5
Q

sequela from togavirus

A

arthritis in females

congenital infections

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6
Q

season for rubellavirus

A

spring

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7
Q

rubellavirus of fetus

A

does not cause lytic infection

prevents normal growth of tissue and chromosomal damage

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8
Q

abnormalities seen in fetus from rubella

A
mental retardation
cataracts
deafness
hepatosplenomegaly
heart and vessel defects
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9
Q

diagnosis rubella newborn

A

anti-viral IgM

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10
Q

diagnosis rubella in adults

A

paired sera show 4x increase from day 7 to 17

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11
Q

vaccination rubella goals

A

vaccinate women of childbearing age

vaccinate children>12 months

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12
Q

vaccination form

A

attenuated virus

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13
Q

genera parvoviridae

A

dependovirus and eryhtrovirus

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14
Q

dependoviruses

A

require helper virus to replicate

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15
Q

infections from erythrovirus B19

A

slapped cheek, macular papular rash

Fifths disease

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16
Q

characteristics parvoviridae

A

smalles
icosahedral capsid, lack envelope
ssDNA

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17
Q

replication parvo

A

dependent on actively dividing host cells

NS1 and NS2 promote replicaiton cycle

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18
Q

hydrops fetalis

A

from accumulation of fluid in abdomen and subcutaneous tissues

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19
Q

diagnosis parvo infection

A

IgM for B19

NAAT of fetal blood

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20
Q

elevated rate of fetal CMV infection

A

in females with lowered T cell responses to CMV antigens

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21
Q

reactivation CMV infections in mother

A

does not lead to fetal abnormalities

seen most frequently in last trimester when fetal development has been established

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22
Q

diagnosis CMV

A

anti-CMV IgM or NAAT

virus isolation possible from throat swabs and urine samples

23
Q

malformations from varicella

A

limbs and muscles

24
Q

malformations from HIV

A

weight deficient, thrush, hepatosplenomegaly, diarrhea

CNS and AIDs symptoms may be evident in newborn

25
Q

recommendations for HIV mother

A

anti-HIV drugs

C-section and not breast feeding

26
Q

e antigen positive Hep B

A

high levels in blood and bodily fluids

can be transmitted to fetus

27
Q

treatment anti HBV for children

A

anti-HBV in utero or perinatally

also pegylated interferon

28
Q

prevention and control HBV for children

A

vaccinated immediately after birth

hyper-immune globulin

29
Q

zika

A

member flaviviridae along with dengue and yellow fever

30
Q

transmission zika

A

sexual intercourse and blood transfusions in addition to mosquito bites

31
Q

symptoms zika

A

fever, rash, joint pain, inflamed eyes

32
Q

serological testing and RT-PCR zika

A

RT-PCR serum in first 2 weeks, urine within 14 days

IgM detectable after 1 week

33
Q

vector zika

A

aedes aegypti and aedes albopictus

34
Q

SV40

A

papovavirus
can cause lytic infection or transformation
tumor virus

35
Q

lytic infection SV40

A

T and t are regulator proteins and bind to viral DNA

late messenger into late (capsid)

36
Q

transformation SV40

A

T and t antigens cause transformation of cells (loss of contact inhibition, replicate with lower growth factor requirement)

37
Q

nonpermissive cells

A

transformation

38
Q

permissive cells

A

lytic

39
Q

HPV 1 and 3

A

plantar warts

40
Q

HPV 2, 3, 10

A

warts on knees and fingers

41
Q

infection papillomavirus

A

basal layer of skin but replication only occurs in these cells as they differentiate

42
Q

treatment skin papillomas

A

podophyllin (extract of mandrake)

43
Q

HPV vaccine

A

HPV L1 protein (capsid protein)
genetically engineered into yeast vector
6,11,16,18+aluminum adjuvant

44
Q

catch up vaccination

A

if 13-26 yo

45
Q

diagnosis HPV

A

nucleic acid based analyses to determine HPV type and viral load

46
Q

transmission HIV

A
blood
semen
vaginal secretions
tissue transplants 
breast milk
47
Q

resource rich HIV transmission

A

MSM primary mode

48
Q

resource poor HIV transmission

A

heterosexual intercourse

49
Q

transmission HBV

A

blood and blood products
sexual intercourse
mother to fetus/child

50
Q

incubation time HSV

A

3-7 days

51
Q

reactivation of HSV2 infections

A

changes in immune system, X irradiation, chemo, stress, infections

52
Q

diagnosis HSV

A

specific antibodies with immunofluorescence

53
Q

treatment HSV

A

acyclovir, valaciclovir, famciclovir are nuceloside analogs