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Patho Flashcards > VI - Neoplasia > Flashcards

VI - Neoplasia Flashcards

2
Q

This term literally means “new growth”.

A

Neoplasia(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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3
Q

An abnormal mass of tissue the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the same excessive manner after the cessation of stimuli which evoked the change.

A

Neoplasm(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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4
Q

Study of tumors.

A

Oncology(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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5
Q

Benign or malignant?Localized

A

Benign(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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6
Q

Benign or malignant?Amenable to surgical removal

A

Benign(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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7
Q

Benign or malignant?Invades and destroys adjacent tissues.

A

Malignant(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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8
Q

What are the two basic components of tumors?

A

Parenchyma and Stroma(TOPNOTCH)

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9
Q

Benign or malignant?Metastasis

A

Malignant(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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10
Q

This component of tumors largely determines its biologic behavior.

A

Parenchyma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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11
Q

This component of tumors determines the name of the growth.

A

Parenchyma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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12
Q

This component of tumors is crucial to the growth of neoplasms since it carries the blood supply and provides support to the growth of cells.

A

Stroma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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13
Q

Benign or malignant?Fibroma

A

Benign(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176

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14
Q

Benign or malignant?Chondroma

A

Benign(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176

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15
Q

Benign or malignant?Adenoma

A

Benign(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176

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16
Q

Benign or malignant?Hepatoma

A

Malignant(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176

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17
Q

Benign or malignant?Papilloma

A

Benign(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176

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18
Q

Malignant neoplasms arising in mesenchymal tissue or its derivatives.

A

Sarcomas(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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19
Q

Benign tumor arising in fibrous tissue is called?

A

Fibroma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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20
Q

A benign cartilagenous tumor is called?

A

Chondroma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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21
Q

This is a benign epithelial neoplasm which produces glandular patterns or neoplasms derived from glands but not necessarily exhibit glandular patterns

A

Adenoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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22
Q

These are benign epithelial neoplasms, growing on any surface that produce microscopic or macroscopic finger-like fronds.

A

Papillomas(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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23
Q

A mass that projects above a mucosal surface to form a macroscopically visible structure.

A

Polyps(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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24
Q

A cancer of fibrous tissue origin.

A

Fibrosarcoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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25
Q

Malignant neoplasms of epithelial cell origin.

A

Carcinoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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26
Carcinoma of squamous cell origin.
Squamous cell carcinoma(TOPNOTCH)
27
Carcinoma of squamous cell origin.
Squamous cell carcinoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176
28
Benign or malignant?Lymphoma
Malignant(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176
29
Benign or malignant?Seminoma
Malignant(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176
30
The extent to which neoplastic cells resemble their normal forebears morphologically and functionally.
Differentiation(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176
31
This is considered a hallmark of malignancy, which literally means "to form backward".
Anaplasia(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.177
32
These cells display marked pleomorphism, nuclei are variable and bizzare in size and shape. Chromatin is course and clumped. Mitoses are often numerous and distinctly atypical.
Anaplastic cells(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.177
33
This term is defined by disorderly but non-neoplastic proliferation of cells, described as a loss in uniformity of individual cells and in their architectural orientation.
Dysplasia(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.178
34
Defined as dysplactic changes which involve the entire thickness of the epithelium.
Carcinoma -in - situ(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.178
35
True or false?Dysplasia always progress to cancer.
False(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.178
36
True or false?Lack of capsule in a neoplastic growth indicates malignancy.
FalseSome benign tumors are not encapsulated.(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.179
37
This term describes the development of secondary implants discontinuous with the primary tumor, in remote tissues.
Metastasis(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.179
38
Next to metastasis, this is the most reliable feature that distinguishes malignant from benign tumors.
Local invasiveness(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.179
39
Methods of dissemination of malignant neoplasms? (3)
SeedingLymphatic spreadHematogenous spread(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.180
40
This is the mode of dissemination of cancers of the ovary and CNS.
Spread by seeding(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.180
41
This is the mode of dissemination more typical of carcinomas.
Lymphatic spread(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.180
42
This is the mode of dissemination more typical of sarcomas.
Hematogenous spread(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.180
43
It is defined as the first lymph node in a regional lymphatic basin that receives lymph flow from a primary tumor.
Sentinel lymph node(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.180
44
What are the most common sites of metastasis involved in hematogenous dissemination of cancer?
Liver and lungs(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.181
45
This substance is a byproduct of metal smelting, a component of alloys, electrical and semiconductor devices which could cause cancer of the lungs and skin and hemangiosarcomas.
Arsenic and its compounds(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.183
46
This substance was formerly used for fire-resistant textiles and construction materials which could cause lung cancer and more prominently malignant mesothelioma
Asbestos(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.183
47
This substance is commonly used as a solvent in paint, rubber, dry cleaning, adhesives and detergents which could cause leukemias and Hodgkin lymphoma.
Benzene(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.183
48
This substance is used as hardener for metal alloys used in aerospace applications and nuclear reactors which is commonly associated with cancer of the lung.
Beryllium and its compounds(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.183
49
This substance is used in solders, batteries and metal alloys commonly associated with cancers of the prostate.
Cadmium and its compounds(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.183
50
This substance is a refrigerant and used as adhesive for plastics, which causes hepatic angiosarcoma.
Vinyl chloride(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.183
51
Inherited gene : Cancer syndromeRB gene :__________
Retinoblastoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
52
Inherited gene : Cancer syndromep53 : ______________
Li Fraumeni Syndrome(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
53
Inherited gene : Cancer syndrome__________ : Familial Adenomatous Polyposis / Colon CA
APC Gene(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
54
Inherited gene : Cancer syndrome_________ : Breast on Ovarian Tumors
BRCA 1 gene(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
55
Inherited gene : Cancer syndrome_________ : Breast Cancer only
BRCA 2 gene(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
56
Inherited gene : Cancer syndromeRET gene : _________
Multiple Endocrine Neoplasia 1 and 2(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
57
Inherited gene : Cancer syndrome__________ : Colon cancer
kras gene(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
58
Normal cellular genes whose products promote cell proliferation.
Proto-oncogenes(TOPNOTCH)
59
Normal cellular genes whose products promote cell proliferation.
Proto-oncogenes(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.188
60
It is a naturally occurring carcinogenic agent produced by some strains of Aspergillus, a mold that grows on improperly stored grains and nuts.
Aflatoxin B(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.209
61
There is a strong correlation between the dietary level of Aflatoxin and what type of cancer?
Hepatocellular Carcinoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.209
62
These substances require metabolic conversion to be carcinogenic.
Indirect - acting carcinogens(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.209
63
These substances stimulate proliferation of the mutated cells.
Promoters(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.210
64
How does ionizing radiation cause cancer?
Through chromosome breakage, translocations and point mutations leading to genetic damage and carcinogenesis.(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.210
65
What is the mechanism of action of UV rays in the formation of neoplastic cells?
UV rays induce formation of pyrimidine dimers within DNA leading to mutations.(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.210
66
This is the only retrovirus that has been demonstrated to cause cancer in humans.
Human T-cell Leukemia Virus -1 (HTLV-1)(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.211
67
HPV strains which has been implicated in the genesis of cervical and anorectal cancer.
HPV 16, 18(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.212
68
EBV has been implicated in the pathogenesis of the following cancers except:A. Burkitt lymphomaB. Lymphoma in HIV patientsC. Nasopharyngeal carcinomaD. Hodgkin lymphomaE. None of the above
E. none of the above(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.212
69
Which hepatitis virus leads to hepatocellular carcinoma?
HBV, HCV(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.213
70
This is the first bacterium to be classified as a carcinogen.
Helicobacter pylori(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.213
71
What type of cancer can be caused by H.pylori?
Gastric adenocarcinoma Gastric MALT lymphomas(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.214
72
These are benign epithelial neoplasms, growing on any surface that produce microscopic or macroscopic finger-like fronds.
Papillomas(TOPNOTCH)
73
Tumor antigens are presented on the cell surface by MHC Class I molecules to which type of T lymphocytes?
CD8+ T lymphocytes(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.215

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