Ventilation and Mechanics of the Lungs (S2) Flashcards
What is the Resting Expiratory Level?
The equilibrium position when the inward force of the elastic recoil of the lungs is balanced by the outward recoil of the chest wall. This corresponds to the state of the lungs as the end of normal quiet expiration.
What does the pleural seal ensure?
Holds the outer surface of the lungs to the inner surface of the chest wall. This seal ensures that the chest wall and lungs move together.
What is the functional residual capacity?
The lung volume that still exists at the end of expiration, at resting expiratory level.
At FRC the elastic forces of the lung and chest wall are balanced.
What muscles are involved in breathing in from the equilibrium position?
Contraction of the diaphragm and the external intercostal muscles
What muscles are involved in breathing out during quiet expiration?
None, passive recoil of the lungs
What muscles are involved in breathing out during forced expiration?
Contraction of the abdominal muscles and the internal/inner intercostal muscles
Describe the steps to breathing in and out?
Inspiratory muscles contract –> thoracic cavity expands –> pleural pressure becomes more negative (increase in Vol) –>transpulmonary pressure increases –> lungs inflate –> alveolar pressure becomes sub-atmospheric –> air flows into the lungs until alveolar pressure= atmospheric pressure
What is Boyle’s Law?
pressure of gas is inversely proportional to its volume
Describe the process involved which leads to the expiration of air out of the lungs (involving Boyle’s Law)
in quiet expiration, when muscle contraction ceases, the elastic recoil of the lung, results in a decrease in volume of the thorax and lung. The decrease in volume leads to and increase in pressure in the terminal and respiratory bronchioles to above atmospheric pressure so air flows back out again.
How far does fresh atmospheric air reach and what does this maintain?
Only reaches as far as the terminal and respiratory bronchioles. Exchange of O2 and CO2 occurs by diffusion between atmospheric air in the terminal and respiratory bronchioles and alveolar gas. Maintaining the composition of alveolar gas
What is the pressure within the pleural cavity and why?
Slightly less than atomospheric pressure, because the lungs and chest wall recoil in opposing directions
Describe the pleural pressure during the respiratory cycle
In quiet expiration the pressure in the pleural cavity remains negative relative to atmospheric pressure, through out the respiratory cycle. In inspiration, as the chest wall expands outwards, the pleural pressure becomes more negative and returns to the original negative pressure as the lungs retunrs to the resting expiratory level.
Describe the affect of diaphragm and ex. IC muscle contraction
The diaphragm moves down to increase the vertical dimensions and the External intercostal muscles move in a ‘bucket handle movement’ to increase the antero-posterior and transverse diameters of the thorax
What muscles are used in force inspiration?
The sternocleidomastoid and scalene muscles of the neck and the serratus anterior and pectoralis major muscles
What forces does the diaphragm have to go against during inspiration?
Stretching of the elastic tissue of the lung and the stretch the film of fluid lining the alveoli (surfactant)
What is compliance?
The volume change per unit pressure change
The stretchiness of the lungs
In terms of stetch, what does higher compliance mean?
The higher the compliance the easier it is to stretch
What two properties determine the elasticity of the lungs?
Elastic tissue in the lungs (primarily elastin fibres)
and
The surface tension forces of the fluid lining the alveoli
What cells produce surfactant?
Describe the constituents or surfactant
Type II pneumocytes (10%)
90% phopholipids 10% protein
important protein = protein A
What is the orientation of the phospholipids in the surfactant?
The hydrophillic ends of the molecules lie in the alveolar fluid and the hydrophobic ends project into the alveolar gas
How does surfactant reduce surface tension?
The phospholipids float on the surface of the lining fluid, interspersed between fluid molecules disrupting the interaction between the surface molecules thereby reducing tension
Essentially breaks up H-bonds
How does surface tension alter the ability to stretch the lung?
the higher the surface tension the harder it is to stretch the lungs
need to exceed elastic recoil
Describe the changes in surface tension as the alveoli expand?
as the alveolus expands its surface area increases and the surfactant molecules are spread further apart, making them less efficient in reducing surface tension.
As the alveolus expands the surface tension of the fluid increases
Why is the force required to expand small alveoli less than that required to expand large ones?
The surfactant molecules are closer together, therefore more efficient in smaller alveoli.