Venous Thromboembolism Flashcards

1
Q

What two conditions are encompassed by venous thromboembolism?

A

Deep vein thrombosis (DVT)
Pulmonary embolism (PE)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are signs and symptoms of a DVT?

A

Swelling and pain in the affected extremity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are signs and symptoms of PE?

A

Shortness of breath
Pleuritic chest pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

If PE or DVT is suspected, what’s a helpful test we can perform?

A

D-dimer

VTE can be excluded without imaging if patient has pre-test probabilities of low, moderate or unlikely in combo with negative d-dimer test

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

If patient is diagnosed with distal DVT (calf veins) and symptoms are not severe, how do we manage?

A

No treatment needed.

Repeat imaging at 1 week
- No change, no treatment
- Significant clot extension, treat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

When should we screen for thrombophilia? What is thrombophilia?

A

Patient age <40 year with recurrent VTE or family history

Blood that clots more easily

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which VTE patients can be treated outpatient?

A

Majority of DVT patients
PE patients without compromised cardiopulmonary function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What’s the ideal analgesic for patients with VTE?

A

Acetaminophen
Opioids may be required for a few days

NSAIDs are effective but increases risk of bleeding, especially if using with anticoagulants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are non-pharms for DVT?

A

Rest if needed(reduces pain and swelling)

Evidence suggests early ambulation is preferred (resolves pain and swelling faster)

Elevate swollen limb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are non-pharms for PE?

A

Oxygen if hypoxic
IV fluids if hypotensive
Vasopressor if hypotensive or organ hypoperfusion (shock)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is a frequent complication of DVT?

A

Post-thrombotic syndrome (PTS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are signs and symptoms of PTS?

A

Chronic swelling and pain
Discomfort when walking
Skin discolouration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Does the compression stockings prevent development of PTS following DVT?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What can graduated compression stockings help with in DVT?

A

Improve edema and pain for DVT.
Relieve symptoms in those who do develop PTS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What patient population should not use graduated compression stockings?

A

Patients with pre-existing peripheral vascular disease (PAD)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the difference between PAD and DVT?

A

PAD= narrowed arteries in the legs
DVT= blood clot in the legs

17
Q

What are the drug classes used in the treatment of VTE?

A
  • Direct oral anticoagulants (DOACs)
  • Warfarin
  • Low molecular weight heparin (LMWH)
  • Fondaparinux
  • Unfractionated heparin (UFH)
18
Q

What are drugs under the DOAC class?

A

Apixaban
Rivaroxaban
Dabigatran
Edoxaban

19
Q

What makes apixaban and rivaroxaban different from dabigatran and edoxaban?

A

Dabigatran and edoxaban can only be used following a 5-10 days of parenteral anticoagulant

Apixaban and rivaroxaban can be used alone

20
Q

If warfarin is used, do you need parenteral anticoagulation?

A

Yes, use together for a minimum of 5 days or until INR ≥2 for 24–48 hours

21
Q

When is parenteral anticoagulation preferred over oral?

A

Patients with significant comorbidities that need to be stabilized

When oral agents are contraindicated or ineffective

22
Q

When parenteral anticoagulation is selected, what are the three options?
Is there a preference out of the three?

A

LMWH
Fondaparinux
UFH

LMWH is recommended

23
Q

What is the

A