Venous Disease Flashcards

1
Q

Venous Anatomy

A

Venous blood drains from the head and neck assisted by gravity when the person is upright.

The lower limbs cannot drain passively – the veins here are divided into superficial and deep veins separated by one-way valves and connected by perforating veins which also contain valves.

Muscle contraction during normal activity ‘massages’ the blood into the deep veins and helps drive it towards the heart. Retrograde flow is prevented by the valves.

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2
Q

Long and Short Saphenous Veins

A
  • Long (great) saphenous vein – passes anterior to the medial malleolus at ankle, up the medial aspect of the calf and thigh to join the common femoral vein at saphenofemoral junction.
  • Short (lesser) saphenous vein – passes posterior to the lateral malleolus at the ankle and up the posterior aspect of the calf. It commonly joins the popliteal vein at the saphenopopliteal junction which usually lies 2cm above the posterior knee crease.
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3
Q

Presentation of Venous Disease

A

It can present in one of four ways – varicose veins, superficial or deep vein thrombosis or chronic venous insufficiency and ulceration.

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4
Q

Venous Symptoms - Pain

A

Patients with uncomplicated varicose veins may have aching discomfort in the leg, itching and a feeling of swelling. Symptoms are aggravated by prolonged standing and towards the end of the day.

The pain of established deep vein thrombosis is deep seated and associated with swelling below the level of the obstruction.

Superficial venous thrombophlebitis produces a red, painful area overlying the vein involved.

Varicose ulceration can be painless.

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5
Q

Venous Symptoms - Swelling

A

Associated with varicose veins, deep venous reflux and deep vein thrombosis.

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6
Q

Venous Symptoms - Discolouration

A

Chronic venous insufficiency causes pigmentation due to deposition of haemosiderin (from breakdown of extravasated blood) in skin leading to lipodermatosclerosis.

This varies in colour from deep blue/black to purple or bright red. It usually affects the medial, lower third but may be lateral if superficial reflux predominates in the short saphenous vein.

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7
Q

Venous Symptoms - Ulceration

A

Venous ulceration is usually seen above the medial malleolus. It only occurs with severe venous disease and is always associated with lipodermatosclerosis.

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8
Q

Varicose Veins - Definition

A

Long tortuous and dilated veins of the superficial venous system.

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9
Q

Varicose Veins - Pathology

A

The deep venous circulation is at a higher pressure than the superficial venous circulation. Where the 2 systems join there are valves which have the purpose of preventing the pressure within the deep system coming out into the superficial system. If these valves go wrong (i.e. become incompetent) then the superficial veins dilate and appear as varicose veins.

The most common sites where this may occur in the lower limb are first at the long saphenous femoral vein junction in the groin, second at the short saphenous popliteal vein junction in the popliteal fossa and third at perforating veins – 3 on the medial calf and in some patients an additional one on the medial thigh (although position of these does vary).

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10
Q

Varicose Veins - Causes

A

Can be broadly divided into primary and secondary causes:

  • Primary – commonest type of varicosities – defect is congenital or even an absence of valves.
  • Secondary – thrombosis of deep or superficial veins, overactive muscle pump e.g. in cyclists, AV malformations, pregnancy, abdominal or pelvis mass, ascites, obesity or constipation.
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11
Q

Varicose Veins - Risk Factors

A

Prolonged standing, obesity, pregnancy, positive family history, oral contraceptives (these need to be stopped 6-8 weeks before surgery due to the risk of DVT) or history of DVT or PE.

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12
Q

Varicose Veins - Clinical Features

A
  • Symptoms – ‘my legs are ugly’ – pain, cramps, tingling, heaviness and restless legs.
  • Signs – oedema, venous eczema, ulcers, haemosiderin skin discolouration, haemorrhage, phlebitis, atrophie blanche – white scarring around a healing ulcer and lipodermatosclerosis (skin hardness from subcutaneous fibrosis caused by chronic inflammation and fat necrosis – may produce inverted champagne bottle).
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13
Q

Varicose Veins - Investigations

A

Colour duplex scanning and marking of perforators, venography to show obstructed veins, collaterals and incompetent perforators and ultrasound to show reflux into superficial veins.

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14
Q

Varicose Veins - Conservative Management

A
  • Treat the underlying cause where possible e.g. obesity or constipation.
  • Education – avoid prolonged standing, wear support stockings, weight loss and regular walks.
  • Criteria for referral – bleeding, pain, ulceration, superficial thrombophlebitis or impact on QOL.
  • Injection sclerotherapy – used for varicosities below the knee if there is no gross sapheno-femoral incompetence. Sclerosant e.g. ethanolamine is injected at multiple sites and the vein compressed for a few weeks to avoid thrombosis. A development of this technique is to mix the sclerosant with air to form foam that is injected at a single site and spreads throughout veins.
  • Laser coagulation – used only for small varicosities and thread veins.
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15
Q

Varicose Veins - Surgical Management

A

More definitive and indicated for patient with sapheno-femoral incompetence and major perforators. There are several choices all of which are day cases:

  • Trendelenburg procedure (high tie) – ligation of the long saphenous at entry into the femoral.
  • Short saphenous vein ligation – ligation of the short saphenous vein deep in popliteal fossa.
  • Multiple avulsions – individual varicosities are stripped through stab incisions on the leg.
  • Vein stripping – not usually performed due to potential of damage to the saphenous nerve.
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16
Q

Varicose Veins - Post-Procedure

A

Bandage the legs tightly, elevate them for 24 hours and give pain relief. Afterwards encourage regular walking e.g. 3 miles per day taken as many short walks.

Possible complications – haematoma (especially in the groin), wound sepsis, damage to cutaneous nerves e.g. the saphenous nerve, superficial thrombophlebitis, deep vein thrombosis or recurrence of varicose veins.

17
Q

Venous Thrombosis - Virchow’s Triad

A

Stasis, endothelial damage and hypercoagulability all lead to venous thrombosis.

18
Q

Superficial Venous Thrombophlebitis

A

Inflammation of superficial veins is associated with intraluminal, usually sterile thrombosis. It affects up to 10% of patients with severe varicose veins and is more common in pregnancy. If recurrent it may be associated with underlying malignancy.

19
Q

Upper Limb Deep Vein Thrombosis

A

Can occur as a primary event due to repetitive trauma of the axillary or subclavian vein e.g. thoracic outlet syndrome. This may follow strenuous unaccustomed use of the arm. It is more common in bodybuilders (perhaps due to associated anabolic steroid use), injecting drug users or patients with a indwelling catheter in the subclavian vein.

Symptoms – arm swelling and discomfort, exacerbated by activity (especially when holding arm overhead). Skin is cyanosed and mottled (especially when dependant). Look for superficial distended veins (collaterals) in the upper arm, over the shoulder or on the anterior chest wall.

20
Q

Lower Limb Deep Vein Thrombosis

A

Will occur in 25-50% of surgical patients and many non-surgical patients but 65% of DVTs that occur below the knee are asymptomatic and these rarely embolise to the lungs.

21
Q

DVT - Risk Factors

A

Older age, pregnancy, synthetic oestrogen (the pill or HRT), trauma, surgery (especially pelvis or orthopaedic surgery), previous DVTs, cancer, obesity, immobility or thrombophilia.

22
Q

DVT - Clinical Features

A

There is usually a mild fever others depend on whether DVT is occlusive or not:
Non-occlusive / Occlusive

  • Pain - Often absent / Usually present
  • Calf tenderness - Often absent / Usually present
  • Swelling - Absent / Present
  • Temperatures - Normal / Increased
  • Superficial veins - Normal / Distended
  • Pulmonary embolism - High risk / Low risk
23
Q

DVT - Differential Diagnosis

A

Cellulitis or a ruptured Baker’s cyst – beware both may co-exist with a DVT.

24
Q

DVT - Investigations

A
  • D-dimer – sensitive but not specific for DVT (raised in infection, pregnancy, malignancy and post-op). A negative result with a low pretest probability score is sufficient to exclude a DVT.
  • Compression ultrasound – this should be performed with a positive D-dimer or an intermediate or high pretest probability score. If negative you may repeat compression ultrasound at 1 week.
  • Thrombophilia test – do this before commencing anticoagulant therapy if there are no predisposing factors for DVT, recurrent DVT or if there is a family history of DVT.
25
Q

DVT - Well’s Score

A

The following all receive 1 point – active cancer, recent immobility, recent surgery, local tenderness, entire leg swollen, calf swelling >3cm (10cm below tibial tuberosity), pitting oedema or collateral superficial veins. Take away 2 points if an alternative diagnosis as likely than that of DVT.

The results3 or more points = high pretest probability and 1-2 points = intermediate pretest probability – for both treat as a suspected DVT and perform a compression ultrasound. 0 points = low pretest probability so measure D-dimer – if positive perform a compression ultrasound.

26
Q

DVT - Management

A

Start low molecular weight heparin e.g. enoxaparin with warfarin initially. Stop LMWH when the INR is between 2-3 and continue to treat for 3 months (or 6 months if no cause was found, lifelong in recurrent DVT or in thrombophilia).

If there is active bleeding, medical therapy fails or to minimise the risk of pulmonary embolism inferior vena caval filters can also be used.

27
Q

DVT - Prevention

A

Stop OCP 4 weeks before surgery, mobilise early, use thromboembolic deterrent (TED) stockings or intermittent pneumatic pressure until 16 hours after surgery.

High risk patients can also be given low molecular weight heparin e.g. 20mg Enoxaparin SC OD starting 12 hours before surgery.

28
Q

Lymphoedema

A

An abnormal collection of interstitial lymph fluid either due to a congenital absence of lymphatics (primary) or secondary to blockage of the lymphatics due to fibrosis (following radiotherapy), infiltration (by a tumour), infection e.g. TB or traumatic (after a dissection of the lymphatics).

Treatment is non-operative – it involves elevation, compression stockings and early intervention if infection occurs.