Vasopressors Flashcards
Norepinephrine
Mechanism?
Physiological effect?
Starting dose?
Dose range?
Strong alpha-1 agonist, weak beta-1 agonist
Increases SVR/venoconstriction (preload)
- 1mcg/kg/min
- 01-1mcg/kg/min
Adrenaline/Epinephrine
Mechanism?
Physical effects (3)
Effect on lactate?
Starting dose?
Dose range?
Alpha-1 agonist (high doses) , beta-1 agonist (low doses)
Increases chronotropy/inotropy
Increases SVR/venoconstriction (preload)
Stabilises mast cells
Beta-2 agonism causes aerobic lactate production in the liver
- 05mcg/kg/min
- 01-1mcg/kg/min
Vasopressin
Mechanism?
Physical effects?
Dose?
Stimulates V1 and V2 receptors, causing vasoconstriction and renal water retention.
Increases SVR/venoconstriction. Can reduce cardiac output. May preferentially cause vasoconstriction of efferent arteriole improving renal function.
0.1-0.06 units/min
Phenylephrine
Mechanism?
Physiologic effect?
Common side effect?
Strength relative to norad?
Dose?
Pure alpha-agonist, causes arterial and venous vasoconstriction.
Increase SVR/venocontriction (preload). Will increase CO if preload responsive (not systolic HF)
Can cause reflex bradycardia (HR reduces to lower BP - BP =HRxSVxSVR)
Around 10x less potent than norad.
50-300mcg/kg/min
Dobutamine
Mechanism?
Primary effect? Secondary effect?
Starting dose?
Dose range?
Mainly beta-1
Positive inotropy with positive chronotropy (increasing cardiac output). Secondary effect is peripheral vasodilation. Effect on BP is unpredictable.
Starting dose: 2.5 mcg/kg/min
1-10 mcg/kg/min