Vasoconstrictors - Pharm 2 Flashcards
Stimulation of presynaptic Alpha-2 receptors results in _________ of NE release from the nerve ending
inhibition
SNS has a thoracolumbar origin of ___ to ___
T1-L2
Preganglia are near the _____ ______
spinal cord
Postganglia secete ________ which act on ______ fibers
norepinephrine / adrenergic
NOREPINEPHRINE: Dopamine enters the ________ vessel. Dopamine beta hydoxylase converts dopamine to _________. An _____ _______ releases NE from the synaptic vessel.
synaptic / norepinephrine / action potential
Norepinephrine signal termination is accomplished by what?
Reuptake, dilution by diffusion, Metabolism by MOA and COMT
Most of norepi is being recycled and some of norepinephrine is being _____ down
broken
Alpha-1
periphery
Beta-1
heart
Beta-2
periphery
Alpha-2
central
When norepinephrine is binds with beta-1 G-proteins cause ________ changes. Review slide 8
confomrational
Review slide 9 for alpha 1 and 2 with norepi
Review slide 9
Alpha-1 Postsynaptic receptor
Activation increases intracellular calcium, smooth muscle contraction, periphereral vasoconstriction, Bronchoconstriction, inhibits insulin secretion, stimulates glycogenolysis and gluconeogenesis, mydriasis, GI relaxation
Alpha-2 receptors: Presynaptic in the PNS
decreases entry of calcium into the cell AND limits the release of norepinpehrine
Alpha-2 receptors: Postsynaptic in the CNS
sedation, decreased sympathetic outflow, decreased BP, platelet aggregation
Beta-1 Postsynaptic receptor
increases HR, increases conduction velocity, increases myocardial contractility
Beta-2 postsynaptic receptor
stimulation leads to smooth muscle relaxation, peripheral vasodilation, decreases BP, bronchodilation, increases insulin secretion, increases glycogenolysis and gluconeogensis, decreases GI mobility
PNS is CRANIOSACRAL origin. Which CN?
III, V, VII, X
The PNS is preganglia near _______ or innervation
organs
PNS postganglia secrete _______ and act on _______ fibers
acetylcholine / cholinergic
Acetylcholine activates both arms of the _______
ANS
Review slide 15
acetylcholine and calcium mediated action potential
SNS stimulation of the heart results in
increased HR, increased conduction velocity, increased automacity, increased contractility
SNS stimulation of the bronchial smooth muscle results in
relaxation
SNS stimulation of the GI tract results in
decreased motility, decreased secretion, sphincter contraction
SNS stimulation of the gallbladder results in
relaxation
SNS stimulation of the urinary bladder results in
smooth muscle relaxation and spincger contraction
SNS timulatioin of the uterus and ureters
contraction
SNS stimulation of the eye
mydriasiss
SNS stimulation of the Liver
glycogenolysis and gluconeogensis
SNS stimulation of the pancreas
Decreased beta cell secretion (decreased insulin)
SNS stimulation of the salivary glands
increased secretion
SNS stimulation of Sweat glands
increase
PNS stimulation of heart
Decreased HR, decreased conduction velocity, slight decrease in contractility
PNS stimulation of the bronchial smooth muscle
contraction (resting state)
PNS stimulation of the GI tract
Increased motility, increased secretion, sphinter relaxation
PNS stimulation of the galllbadder
contraction
PNS stimulation of the urinary bladder
smooth muscle contraction, spincter relaxation
PNS stimulation of the uterus
variable
PNS stimulation of the ureter
relaxatioin
PNS stimulation of the eye
miosis
PNS stimulation of the liver
glycogen synthesis
PNS stimulation of the salivary gland
marked increase in secretion
PNS stimulation of sweat glands
increases
Extended exposure to agonists reduces the number, but not their response. Results in tachyphylaxis.
down regulation
Chronic depletion of catecholamines or use of antagonists increases the number of receptors, but not their SENSITIVITY. May account for withdrawal syndrome with beta blockers.
Up Regulation
OCCURS RAPIDLY. Inability of the receptor to bind G protein (alter the function of the receptor)
Receptor uncoupling
OCCURS more SLOWLY. Movement of receptors from the cell surface to intracellular compartments.
Sequestration
Rapidly diminishing response to successive doses of a drug, rendering it less effective. The effect is common with drugs acting on the nervous system
Tachyphylaxis
T/F There is a residual basal activity of the ANS
TRUE
Uncontrolled release of catecholamines due to an adrenal gland tumor that results in constant SNS stimulation
pheochromocytoma
Catecholamines are considered both _______ and _________
neurotransmitters and hormones
Catecholamines act on _______ receptors
adrenergic
Catecholamines have both the ____ and ____ group
catechol and amine
Sympathomimetics, which means they mimic the SNS, they do not all have to be _________.
catecholamines
Sympathomimetics are classified according to their selectivity for stimulating ____ and/or _____ receptors
alpha / beta
INDIRECT-ACTING sympathomimetics are considered synthetic ___________. They work by causing release of endogenous neurotransmitter _________ from ______sympathetic nerve endings
non-catecholamines / norepinephrine / postganglionic
DIRECT-ACTING sympathomimetics are ________ and ________
catecholamines and synthetic non-catecholamines
All sympathomimetics are derived from __________
B-phenylethylamine
Presence of hydroxyl groups on the 3 and 4 position of the benzene ring of the B-phenylethylamine creates a catachol. Drugs with this composition are _______
catecholamines
Sympathomimetics are most often used as _____ ________ to improve cardiac contractility OR ________ to elevate blood pressure from unacceptable low levels.
positive inotrope / vasopressor
The only time a vasopressor should be used is when the patient’s blood pressure must be increased __________ to avoid pressure-dependent reductions in organ perfusion with subsequent ischemia
immediately
Other uses for sympathomimetics
treatment of brnochospasm in the asthmatic patient, management of anaphylaxis, addition to local anesthetic to slow systemic absorption of local anesthetic from site of infiltration or injection