Vasoactive Peptides Flashcards
Captopril Type & indication
HTN
Captopril Contraindication
no ACE inhibitors in pregnancy due to renal damage of fetus
Captopril MOA
ACE Inhibitor
Captopril Route of Admin
oral
Captopril Adverse Effects
severe stomach pain, chest pain, allergic reaction. Cough typical with ACE inhibitors.
Captopril Notes
ACE is also a kininase, so when you block it, you see increased bradykinin, which is a vasodilator and is thought to be what causes cough in people.
Enalapril Type & indication
HTN
Enalapril Contraindication
no ACE inhibitors in pregnancy due to renal damage of fetus
Enalapril MOA
ACE inhibitor
Enalapril Route of Admin
oral
Enalapril Adverse Effects
severe stomach pain, chest pain, allergic reaction. Cough typical with ACE inhibitors.
Enalapril Notes
ACE is also a kininase, so when you block it, you see increased bradykinin, which is a vasodilator and is thought to be what causes cough in people.
Losartan Type & indication
HTN
Losartan Contraindication
no AT R-inhibitors in pregnancy due to risk of renal damage in fetus
Losartan MOA
Angiotensin R-inh
Losartan Route of Admin
oral
Losartan Adverse Effects
diarrhea, insomnia, nasal congestion.
Losartan Notes
Blocking the receptor does not block ACE action to breakdown kinins like bradykinin
Valsartan Type & indication
HTN
Valsartan Contraindication
no AT R-inhibitors in pregnancy due to risk of renal damage in fetus
Valsartan MOA
Angiotensin R-inh
Valsartan Route of Admin
oral
Valsartan Adverse Effects
stomach pain, nausea
Valsartan Notes
Blocking the receptor does not block ACE action to breakdown kinins like bradykinin
Icatibant Type & indication
Inflammatory Responses
Icatibant MOA
Bradykinin R inh
Icatibant Route of Admin
oral
Icatibant Adverse Effects
stomach pain, nausea
Aprotonin Type & indication
Inflammatory Responses
Aprotonin MOA
Kallikrein inh
Aprotonin Route of Admin
IV
Aprotonin Adverse Effects
MI, stroke, kidney failure
Desmopressin (DDAVP) Type & indication
Diabetes insipidus, control of bleeding in Hemophilia A and classic vWF disease, also bedwetting
Desmopressin (DDAVP) MOA
Increases(cAMP) in renal tubular cells which leads to decreased urine volume and increased urine osmolality; increases plasma levels of vWF, factor VIII, and t-PA
Desmopressin (DDAVP) Drug Action/Pd
reduces urine volume and increase concentration.
Desmopressin (DDAVP) Route of Admin
Intranasal or IV
Desmopressin (DDAVP) Adverse Effects
Desmopressin +excessive fluid consumption =hyponatremia, which can lead to seizures, brain swelling, coma, and death
Bosentan Type & indication
pulmonary hypertension
Bosentan MOA
endothelin R-inhibitor
Bosentan Adverse Effects
liver problems, stomach pain, nausea
