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Cardio Drugs > Vasoactive Peptides > Flashcards

Vasoactive Peptides Flashcards

1
Q

Captopril Type & indication

A

HTN

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2
Q

Captopril Contraindication

A

no ACE inhibitors in pregnancy due to renal damage of fetus

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3
Q

Captopril MOA

A

ACE Inhibitor

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4
Q

Captopril Route of Admin

A

oral

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5
Q

Captopril Adverse Effects

A

severe stomach pain, chest pain, allergic reaction. Cough typical with ACE inhibitors.

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6
Q

Captopril Notes

A

ACE is also a kininase, so when you block it, you see increased bradykinin, which is a vasodilator and is thought to be what causes cough in people.

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7
Q

Enalapril Type & indication

A

HTN

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8
Q

Enalapril Contraindication

A

no ACE inhibitors in pregnancy due to renal damage of fetus

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9
Q

Enalapril MOA

A

ACE inhibitor

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10
Q

Enalapril Route of Admin

A

oral

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11
Q

Enalapril Adverse Effects

A

severe stomach pain, chest pain, allergic reaction. Cough typical with ACE inhibitors.

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12
Q

Enalapril Notes

A

ACE is also a kininase, so when you block it, you see increased bradykinin, which is a vasodilator and is thought to be what causes cough in people.

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13
Q

Losartan Type & indication

A

HTN

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14
Q

Losartan Contraindication

A

no AT R-inhibitors in pregnancy due to risk of renal damage in fetus

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15
Q

Losartan MOA

A

Angiotensin R-inh

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16
Q

Losartan Route of Admin

A

oral

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17
Q

Losartan Adverse Effects

A

diarrhea, insomnia, nasal congestion.

18
Q

Losartan Notes

A

Blocking the receptor does not block ACE action to breakdown kinins like bradykinin

19
Q

Valsartan Type & indication

A

HTN

20
Q

Valsartan Contraindication

A

no AT R-inhibitors in pregnancy due to risk of renal damage in fetus

21
Q

Valsartan MOA

A

Angiotensin R-inh

22
Q

Valsartan Route of Admin

A

oral

23
Q

Valsartan Adverse Effects

A

stomach pain, nausea

24
Q

Valsartan Notes

A

Blocking the receptor does not block ACE action to breakdown kinins like bradykinin

25
Q

Icatibant Type & indication

A

Inflammatory Responses

26
Q

Icatibant MOA

A

Bradykinin R inh

27
Q

Icatibant Route of Admin

A

oral

28
Q

Icatibant Adverse Effects

A

stomach pain, nausea

29
Q

Aprotonin Type & indication

A

Inflammatory Responses

30
Q

Aprotonin MOA

A

Kallikrein inh

31
Q

Aprotonin Route of Admin

A

IV

32
Q

Aprotonin Adverse Effects

A

MI, stroke, kidney failure

33
Q

Desmopressin (DDAVP) Type & indication

A

Diabetes insipidus, control of bleeding in Hemophilia A and classic vWF disease, also bedwetting

34
Q

Desmopressin (DDAVP) MOA

A

Increases(cAMP) in renal tubular cells which leads to decreased urine volume and increased urine osmolality; increases plasma levels of vWF, factor VIII, and t-PA

35
Q

Desmopressin (DDAVP) Drug Action/Pd

A

reduces urine volume and increase concentration.

36
Q

Desmopressin (DDAVP) Route of Admin

A

Intranasal or IV

37
Q

Desmopressin (DDAVP) Adverse Effects

A

Desmopressin +excessive fluid consumption =hyponatremia, which can lead to seizures, brain swelling, coma, and death

38
Q

Bosentan Type & indication

A

pulmonary hypertension

39
Q

Bosentan MOA

A

endothelin R-inhibitor

40
Q

Bosentan Adverse Effects

A

liver problems, stomach pain, nausea

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