Vasoactive Drugs Flashcards
outflow of sympathetic
thoracolumbar
outflow of parasympathetic
craniosacral
post-ganglion transmitter of the sympathetic
noradrenaline
- alpha and beta receptors
post-ganglion transmitter of parasympathetic
acetylcholine
- nicotinic and muscarinic receptors
excess parasympathetic response
Rule of B’s
- blindness
- bronchial secretions
- bronchospasm
- bradycardia
- berstalsis
- bile secretion
- bladder contraction
alpha 1 receptors
- location
- effect
Post-synaptic
- smooth muscle vasoconstriction = elevated BP
alpha 2 receptors
- location
- effect
Pre-synaptic
- inhibits NA release centrally
- hypotension, sedation, analgesia
B1 effect
- increase cardiac contractility
- renin secretion
B2 effect
- vessel dilation
- bronchial relaxation
- uterine relaxation
- bladder relaxation
drug that stimulates PNS
neo
post-ganglionic PNS receptors are…
so what should be given an blockade ?
muscarinic
–> give anti-cholinergic = atropine or glyco ( BBB )
stimulants of sympathetic act on?
adrenoreceptors
antagonists of sympathetic response act at…
blocking alpha and beta
B1 effect drugs are called …
inotropes
drugs that have alpha 1 effects are called …
vasopressors
name drugs that are bot an inotrope and vasopressor
adrenaline and NA
only a vasopressor
phenylephrine
only an inotrope
Dobutamine
indirect acting sympathomimetic
ephedrine
alpha 1 vasopresor
Phenylephrine
alpha 2 agonist
clonidine
- sedative and analgesic
inhibits lipolysis and gluconeogenesis
B-blocker
combined alpha and beta blocker
Labetelol
drug of choice for management of hypotension given 5-10mg bolus IV
ephedrine
- may cause tachycardia
