Vasoactive, Autonomic, and Cardiovascular Drugs - Med Table Flashcards
Metoprolol receptor
Beta 1
-Beta 2 at high doses
Metoprolol dose
2.5-5 mg (up to 15mg)
I let a resident call it “METROpolol” 2.5-5 times before I correct them; 15 if I’m feeling mean.
Metoprolol IV onset
onset: 1-2 min
peak: 20 min
The resident called it “METROpolol” within the first 1-2 minutes of rounds
The resident reached PEAK embarrassment after 20 minutes of being berated by the attending
Metoprolol DOA
5-8 hr
Despite being humiliated on rounds, the resident will still call it “METROpolol” within 5-8hrs later.
Labetalol receptor
Alpha 1, Beta 1, Beta 2
Labetalol dose
2.5-20 mg (realistically 5-10 mg)
I give my lab 2.5-20 treats daily, but usually 5-10. He’s a really good boy, OK!
Labetalol onset
onset: 1-2 min
peak: 5-15 min
My lab settles down about 1-2 minutes after guests walk in.
My lab is fully relaxed 5-15 minutes after
Labetalol DOA
2-8 hr
My lab will hang around for 2-8 hours at a time then he goes away into his kennel
Esmolol receptor
Beta 1 ANTagonist (cardioselective)
-lowers HR, prevents arrhythmia, can lower BP (FDA approved for post-intubation elevations)
Esmolol dose
0.5-1.0 mg/kg (usually 10mg boluses)
I mistakenly bought a “Tickle Me Esmo” that was rated 0.5-1 star off of Temu. I see why it was $10
Esmolol onset
onset: 1 min
peak: 5 min
It only took me 1 minute to realize I accidentally bought a “Tickle Me Esmo” off Temu. My daughter realized after 5 minutes.
Esmolol DOA
10-30 min
I let my daughter play with “Tickle Me Esmo” from Temu for 10-30 mins until I realized it was teaching her how to swear.
Ephedrine receptor
Alpha 1, Beta 1> Beta 2
Ephedrine dose
5-10 mg IV MAX: 50 mg
25-50 mg IM Q4-6 hr
I’Ve become PHED up after 5-10 slides into an NA 1 lecture
The MAX I can handle is 50 slides
I’M trying my best from slide 25-50 but I need a 4-6 hr break in between
Ephedrine onset
IV: ~1 min; peak: 2-5 min
IM: 10-20 min
I’Ve become PHED up with NA 1 within 1 minute of studying
My PEAK annoyance is within 2-5 min of studying
I’M PHED up during off site zoom lectures within 10-20 mins
Ephedrine DOA
10-60 min
I stay PHED up with NA 1 for between 10-60 minutes until I get used to it
Phenylephrine receptor
Alpha 1
Phenylephrine dose
bolus: 40-100 mcg IV
“Chill lady, your pt’s BP will be PHEN with 40-100mcg!”
Phenylephrine DOA
<5 min
“I said your pt would be PHEN, I didn’t say for how long!”
Vasopressin receptor
V1 and V2
Vasopressin dose
0.02-0.04 u/min infusion
Vasopressin DOA
10-20 min
Epinephrine receptors/dose
Beta 2: 1-2 mcg/min
Beta 1 + beta2 : 2-10 mcg/min
Alpha 1: >10 mcg/min
Betta 2 give 1-2mcg/min
Want both? Betta give 2-10mcg/min
A1 response? give >10mcg/min
Epinephrine doses
-ACLS
-intraop bolus
Resusc: 1 mg IV
Intraop bolus: 10-100 mcg
Epi onset
immediate
Epi DOA
5-10 min
Calcium Chloride dose
500-1000 mg
Calcium Chloride onset
<1 min
peak: <1 min
Calcium Chloride DOA
10-20 min
Atropine receptors
anticholinergic
Atropine dose
0.5 mg Q 3-5 min