Vasculitis ( PAN in other deck ) Flashcards
pANCA, Necrotizing vasculitis of small vessels, Glomerulonephritis, Pulmonary Hemorrhage
Microscopic Polyangiitis
How would you confirm a diagnosis of MPA ?
RBC Casts in the urine + pANCA + Biopsy
Palpable Purpura, Arthritis, Abdominal Pain, Glomerulonephritis
HSP- That is the triad.
Leukocytoclastic Vasculitis, What is this disease mediated by ?
HSP —-> IgA
ENT LUNG and KIDNEY, Nose caving in, What is this disease and what is it mediated by ?
Wegener, cANCA
Pauci-Immune Glomerulonephritis and Nodular Granulomas
Wegners, cANCA
cANCA
Wegners
Peripheral Neuropathy, Asthma, Eosinophilia —> what mediates this disease ?
This is Churg Strauss. It is mediated by pANCA.
Polymyalgia Rheumatica and greatly increased sed rate —> what mediates this disease and a significant comorbidity ?
This is temporal arteritis. Consequence of aortic arch inflammation. BLINDNESS if not treated with steroids ASAP
MI in a young asian child with cervical lymphadenopathy , beau’s lines and lymphocytosis?
Kawasaki- mucocutaneous lymphnode syndrome
Aneurysms, bruise, and renovascular disease in a small asian child
Takayasu
Transmural panarteritis + Granulomas in the internal elastic membrane. Skipping lesions
Temporal arteritis
Pulselessness Disease, Nausea vomiting and ischemic bowel
Takayasu’s disease
Jaw Claudification, Morning stiffness, blurred vision ?
Temporal arteritis
Eosinophillic necrotizing granulomas and pANCA , Glomerulonephritis
Churgg Strauss,
Hep B infection
PAN
What are the most common findings in PAN ?
Fever and Weight Loss
Neuropathy
Arthritis / Myalgia / Arthralgia
Are PAN and Cutaneous PAN the same thing ?
What is cutaneous PAN assicated with ?
No they are separate entities
Hep-C infection
What is this ?
Nodular cavitating Lesion of Wegners
What is this disease and what do you see ?
Vasculitis of arteries and veins, Granulamatous with polyangiitis
What do you see here ?
Nodular Kidney Lesions —>Wegners
What is this pathology and what disease is this associated with ?
Necrotizing vasculitis of the interlobular artery in the kidney
Wegners Vasculitis
What is Churg Straus ?
Wegners but with tons of eosinophils
What is this pathology and associated disease ?
This is necrotizing vasculitis with tons of eosinophils —> Red cytoplasm and BILOBED NUCLEI
What is the pathogenesis of this disease ?
thromboangiitis obliterans is an inflammatory vaso-occlusive disease that predominantly affects the vascular supply to the lower limbs in young adult male tobacco smokers, although women and older adults can also be affected.
Describe the pathological findings in Buergers disease
Segmental Transmural Inflammation without necrosis in the acute phase. In the chronic phase there will be organization and cannalization of the thrombus
If a patient has this with gangreen on his hands is the disease acute or chronic and why ?
Chronic Buergers because the thrombus is organized
Purpura, Abdominal Pain, arthritis and GN
Arthralgias?
Heleno Schoen Purpura
What is the pathology of HSP ?
Leukocytoclastic vasculitis
What is this disease ?
This is the granuloma formation with Takasaku Arteritis
What are the 4 aspects of the pathology to Takasaku Arteritis ?
- Segmental
- Transmural
- Necrotizing
- Loosly Granulamatous Multinucleated Giant Cells
Describe this pathology
This is Transmural arteritis with a prominant granuloma narrowing the lumen of the vessel
Temporal Arteritis
Describe this pathology
Giant Cells eating up the internal elastic media. Temporal Arteritis
