Vasculitis Flashcards
What does P and C-ANCA stand for
P is for perinuclear staining of the anti-neutrophil antibody and C is for cytoplasmic/diffuse staining of the antibody
What are the 3 main ANCA associated small vessel vasculitidies
- Wegners: C-ANCA (PR3-ANCA to be specific)
- Churg-Strauss: associated with eosinophils and asthma
- Microscopic polyangiitis
What are the two large vessel vasculitidies
- Giant cell: older than 50 & associated with PMR
2. Takayasu’s: younger than 50
What are the two medium vessel vasculitidies
- Polyarteritis nodosa
2. Kawasaki
What are the 4 main immune complex vasculitidies
- Anti GBM
- Cryoglobulinemic
- IgA (Henoch-schonlein)
- Hypocomplementemic urticarial
What are the two variable vessel vasculitidies
- Behcets
2. Cogan’s syndrome: prominent ocular involvement and inner ear disease
What skin finding do you expect in small vessel vasculitis
palpable purpura
What skin finding do you expect in in hypersensitivity vasculitis
palpable purpura commonly on legs
Histology of a small vessel vasculitis
Fibrinoid necrosis of vessel walls, nuclear dust from neutrophil fragmentation (hence name leukocytoclastic vasculitis)
Tx of a small vessel vasculitis
Topical steroids and antibiotic creams, if systemic symptoms may need oral prednisone
Henoch Schonlein Purpura histology
Vascular deposition of IgA1 immune complexes
Henoch Schonlein Purpura etiology
In the springtime classically following a URI or strep infection
Henoch Schonlein Purpura associated symptoms
Abdominal pain +/- bloody stools +/- intussuception
Arthralgias
Nephritis
Henoch Schonlein Purpura Skin findings
Nonthromobocytopenic palpable purpura on lower extremities and butt. New lesions appear with ambulation and resolve more rapidly with bed rest
Tx of Henoch Schonlein Purpura
Corticosteroids
