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MSK > Vasculitis > Flashcards

Vasculitis Flashcards

1
Q

Vasculitis is inflammation of what?

A

Blood vessels

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2
Q

Which blood vessels does vasculitis affect?

A

Any

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3
Q

Which type of vasculitis has the worst prognosis?

A

Small vessel

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4
Q

What can cause secondary vasculitis?

A

Infection, drug, toxin, cancer

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5
Q

Vasculitis causes systemic symptoms e.g. fever, weight loss, fatigue. True or false?

A

True

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6
Q

What are the 2 types of large vessel vasculitis?

A

Takayasu Arteritis

Giant cell arteritis

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7
Q

Which type of large vessel vasculitis affects those < 40 and is more common in females?

A

Takayasu Arteritis

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8
Q

What race is Takayasu arteritis more common in?

A

Asians

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9
Q

Which type of large vessel vasculitis affects those > 50?

A

Giant cell arteritis

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10
Q

What vessel is most often involved in giant cell arteritis?

A

Temporal artery

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11
Q

Temporal arteritis has an association with which other condition?

A

Polymyalgia rheumatica

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12
Q

What is the major risk of temporal arteritis?

A

Blindness

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13
Q

If there are symptoms of temporal arteritis, what test should you do? Should you always discount it if it comes back negative?

A

Temporal biopsy- there may be skip lesions so do not discount if negative

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14
Q

What is the main treatment for giant cell arteritis?

A

Steroids (can consider sparing agents)

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15
Q

What is the starting dose of steroids for giant cell arteritis?

A

40-60mg

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16
Q

What are the two types of medium vessel vasculitis?

A
  • Kawasaki Disease

- Polyarteritis Nodosa

17
Q

Who is Kawasaki disease seen in?

A

Children under 5

18
Q

What are the most important vessels to consider in Kawasaki Disease?

A

Coronary arteries

19
Q

Where in the vessels does polyarteritis nodosa affect?

A

Vessel bifurcations

20
Q

What other systems can polyarteritis nodosa affect?

A

Skin, gut, kidneys

21
Q

What condition is polyarteritis nodosa associated with?

A

Hep B

22
Q

Granulomatous inflammation of the respiratory tract, small and medium vessels. Necrotising glomerulonephritis is common. What condition is this?

A

Granulomatosis with polyangiitis

23
Q

Eosinophilic granulomatous inflammation of the respiratory tract, small and medium vessels. Associated with asthma. What condition is this?

A

Eosinophilic Granulomatosis with Polyangiitis

24
Q

Necrotising vasculitis with few immune deposits, necrotising glomerulonephritis is common. What condition is this?

A

Microscopic Polyangiitis

25
Q

Which sex is GPA more common in?

A

Males

26
Q

What is the typical age onset of GPA?

A

35-55

27
Q

Saddle nose is associated with which condition?

A

GPA

28
Q

EPGA is associated with asthma development when?

A

Later in life

29
Q

Which cases of vasculitis are ANCA +?

A

GPA
EPGA
MP

30
Q

Which subtype of ANCA is associated with GPA?

A

cANCA

31
Q

Which subtype of ANCA is associated with EGPA?

A

pANCA

32
Q

Does ANCA vary with disease activity?

A

Yes

33
Q

What happens to complement during disease activity?

A

Levels fall

34
Q

What is the treatment for localised and early systemic ANCA associated vasculitis?

A

Methotrexate and steroids

35
Q

What is 1st line treatment for generalised and systemic ANCA associated vasculitis?

A

Cyclophosphamide and steroids

36
Q

What is 2st line treatment for generalised and systemic ANCA associated vasculitis?

A

Rituximab and steroids

37
Q

What is the treatment for refractory ANCA associated vasculitis?

A

IV immunoglobulins and rituximab

38
Q

What usually precedes Henoch-Schonlein purpura?

A

UTI, pharyngeal or GI infection

39
Q

What is usually the cause of Henoch-Schonlein purpura?

A

Group A strep

MSK (6 decks)

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