Vasculitis

Question 1

Target population for temporal arteritis.

Answer 1

Older women(> 65 y.o)

Question 2

Arteries affected for temporal arteritis.

Answer 2

Large elastic arteries that branch from the aorta.

Question 3

How does temporal arteritis look in section?

Answer 3

Panarteritis with a granulomatous inflammation first, then fibrosis.

Question 4

What happens if there’s cranial arteritis in the opthalmic artery?

Answer 4

May have temporary blindness known as amaurosis fugax.

Causes ischemia of the optic nerve.

Question 5

Prevents blindless.

Answer 5

Corticosteroids

Question 6

Pain associated with temporal arteriosis.

Answer 6

Unilateral headaches where the artery is affected.

Question 7

Arteries affected by polyarteritis nodosa.

Answer 7

Muscular arteries

Question 8

Age group most affected by polyarteritis nodosa.

Answer 8

Young people, more common in men.

Question 9

Part of the wall affected in polyarteritis nodosa.

Answer 9

Transmural.

Question 10

What forms the nodes in polyarteritis nodosa?

Answer 10

Immune complexes (Hep B antigen).

Question 11

Effects of polyarteritis nodosa on the vessels.

Answer 11

Thrombosis, infarction, ischemia.

Question 12

Early lesions of polyarteritis nodosa have what?

Answer 12

Fibrinoid necrosis (the necrosis looks like fibrin).

Question 13

Diseases associated with polyarteritis nodosa.

Answer 13

Polyneuropathy
Kidney disease
GI disease

Question 14

This is EXTREMELY RARE in polyarteritis nodosa.

Answer 14

Pulmonary involvevment.

Question 15

Skin lesion associated with Polyarteritis nodosa.

Answer 15

Livedo reticularis

Question 16

ANCA

Answer 16

Anti-Neutrophil Cytoplasmic Antibody

Question 17

ANCA-associated vasculopathies

Answer 17

The patient makes antibodies against the granules in their own polys, and the granules are released and cause vascular damage.

Question 18

Types of ANCA antibodies.

Answer 18

c-ANCA and p-ANCA.

Question 19

ANCA’s are made against _________.

Answer 19

Azurophilic granules.

Question 20

A type of ANCA vasculitis.

Answer 20

Wegener’s

Question 21

Wegener’s is AKA what?

Answer 21

Granulomatosis with Polyangiitis

Question 22

Areas affected by Granulomatosis with Polyangiitis

Answer 22

Kidney, lung sinuses.

Question 23

Most Wegener patients have this in their serum.

Answer 23

C-ANCA

Question 24

Necrotizing vasculitis of small arteries and veins.

Answer 24

Granulomatosis with polyangiitis.

Question 25

Unique thing about Wegener’s.

Answer 25

Can be extra vascular, so we see granulomatous lesions in the lungs, kidney, and nasal cavity.

Question 26

Wegener’s Renal Disease

Answer 26

Glomerular
No immune deposits
Granulomas in the kidney are rare

Question 27

HS purpura involves what?

Answer 27

IgA antibodies.

Question 28

Common cause of purpura.

Answer 28

Leukocytoclastic vasculitis.