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MD2 Cardiovascular > Vasculitis > Flashcards

Vasculitis Flashcards

1
Q

How is vasculitis classified?

A

by vessel size

  • large vessel (aorta or main branches)
  • medium vessel (main visceral arteries and their branches)
  • small vessel (small intraparenchymal arteries, arterioles, capillaries, venules
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2
Q

How is vasculitis classified?

A

by vessel size

  • large vessel (aorta or main branches)
  • medium vessel (main visceral arteries and their branches)
  • small vessel (small intraparenchymal arteries, arterioles, capillaries, venules
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3
Q

Describe giant cell arteritis

A
  • cranial or temporal arteritis
  • common in elderly
  • symptoms: headache, temporal artery and scalp tenderness, jaw claudication, amourosis fugax or sudden blindness (typically unilateral)
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4
Q

What vessels does giant cell arteritis affect?

A
  • cranial or temporal arteritis

- common in elderly

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5
Q

What are the symptoms of giant cell arteritis?

A

headache, temporal artery and scalp tenderness, jaw claudication, amourosis fugax or sudden blindness (typically unilateral)

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6
Q

What vessels does giant cell arteritis affect?

A
  • cranial or temporal arteries
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7
Q

What are the investigation findings in GCA?

A
  • high CRP
  • high platelets
  • high alk phos
  • low Hb
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8
Q

What is polyarteritis nodosa?

A
  • a vasculitis affecting medium-sized arteries
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9
Q

What is polyarteritis nodosa?

A
  • a necrotising vasculitis affecting medium-sized arteries leading to infarction in affect organs
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10
Q

What is polyarteritis nodosa?

A
  • a necrotising vasculitis affecting medium-sized arteries leading to thrombosis and aneurysm which causes infarction in affect organs
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11
Q

What is polyarteritis nodosa?

A
  • a necrotising vasculitis affecting medium-sized arteries leading to thrombosis and aneurysm which causes infarction in affected organs
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12
Q

What are the symptoms of PAN (polyarteritis nodosa)?

A
  • systemic sx
  • skin rash
  • renal
  • cardiac
  • GI
  • GU
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13
Q

What are the investigation findings in PAN?

A
  • high CRP
  • FBE: high WCC, anaemia, mild eosinophilia
  • ANCA -ve
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14
Q

what is the management of PAN?

A

control BP + steroids +/- cyclophosphamide

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15
Q

what is microscopic polyangitis?

A
  • necrotising vasculitis affecting small and medium sized vessels
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16
Q

what is microscopic polyangitis (MPO)?

A
  • necrotising vasculitis affecting small and medium sized vessels
17
Q

what are the symptoms of microscopic polyangitis?

A
  • rapidly progressive glomerulonephritis

- pulmonary haemorrhage in 30%

18
Q

what are the investigation findings in polyarteritis nodosa?

A
  • pANCA +ve
19
Q

what is Wegener’s granulomatosis?

A
  • granulomatosis with polyangitis

- 100% mortality (from renal failure) if left untreated

20
Q

what are the investigation findings in polyarteritis nodosa?

A
  • pANCA +ve
21
Q

what is Wegener’s granulomatosis?

A
  • granulomatosis with polyangitis

- 100% mortality (from renal failure) if left untreated

22
Q

what are the investigation findings in Wegener’s granulomatosis

A
  • cANCA +ve
23
Q

Are the levels of ANCA related to disease severity?

A

yes

24
Q

T/F Are the levels of ANCA related to disease severity?

A

True

25
Q

T/F polyarteritis nodosa is associated with a positive ANCA

A

False

26
Q

T/F Henoch-Schonlein purpura is an IgA vasculitis

A

True

27
Q

T/F vasculitis can not be associated with HBV or HCV

A

False

MD2 Cardiovascular (8 decks)

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