Vasculitis

Question 1

medium sized artery vasculitis not assc with granulomas or glomerulonephristis

Answer 1

Polyarteritis Nodosa

Question 2

Polyarteritis Nodosa necrotizing or non-necrotixing

Answer 2

necrotizing

Question 3

VASO-OCCULSIVE Dz = Thrombosis

Predominantly affects the vascular supply to the lower limbs and HANDS!!!

Answer 3

Burgers

Question 4

Associated with HepC viral infection

Answer 4

1. Cryoglobulinemia Vasculitis

2. Cutaneous Polyarteritis Nodosum (limited to skin)

Question 5

assc with Hep B

Answer 5

Polyarteritis Nodosa

Question 6

assc with elevated IgA

Answer 6

Henoch-Schonlein Purpura

Question 7

assc with eosinophillia

Answer 7

ergic Granulomatosis With Polyangiitis [AGPA] (Churg Strauss Syndrome)

Question 8

Antibodies directed against collagen, elastin, lamin, endothelial cells

ANCAs directed against MPO, lactoferrin and elastin

Answer 8

Bergurs

Question 9

Immune complex (IC)-mediated small vessel vasculitis of the skin

In capillaries, post cap venules, and arterioles

Answer 9

Hypersensitivity Vasculitis

Question 10

Classic tetrad of purpura, arthritis, abdominal pain, GN

Answer 10

Henoch-Schonlein Purpura

Question 11

AM stiffness, shoulder + pelvic girdle pain

Answer 11

Polymyalgua rheumatic (in association with GCA)

Question 12

adolescent girls and young women of Asian descent < 40 yo

Answer 12

Takayasu’s Arteritis

Question 13

glomerulonephritis and lung involvement with pulmonary hemorrhage

Answer 13

Microscopic Polyangiitis

Question 14

Classic Triad of ENT, respiratory tract and kidney involvement

Answer 14

Granulumatosis With Polyangiitis (Wegener’s Granulomatosis)

Question 15

livedo reticularis

Answer 15

Polyarteritis Nodosa

Question 16

Necrotizing vasculitis of small vessels, primarily postcapillary venules

NOT associated with granulomas

Answer 16

Henoch-Schonlein Purpura

Question 17

pANCA

Answer 17

Microscopic Polyangiitis

Question 18

Associated with glomerulonephritis and granuloma formation with a palaside of histiocytes (~rheumatoid nodules)

Answer 18

Granulumatosis With Polyangiitis (Wegener’s Granulomatosis)

Question 19

TRIAD OF: asthma + eosinophilia + vasculitis

Answer 19

Allergic Granulomatosis With Polyangiitis [AGPA] (Churg Strauss Syndrome)

Question 20

ocular lesions
pyoderma gangenousum
arthritis
Oral and genital ulcers

Answer 20

Bechet’s Disease

Question 21

Vasculitis confined only to the brain, meninges, or spinal cord.

Answer 21

Primary Angiitis of the CNS

Question 22

Neutrophils + fibrinoid necrosis

Answer 22

Polyarteritis Nodosa

Question 23

leukcoyotoclasia (destruction of WBCs)→ dispersing nuclear dust

Answer 23

Hypersensitivity Vasculitis

Question 24

iAssociated with purpura, arthritis, glomerulonephritis, and colicky abdominal pain

Answer 24

Hypersensitivity Vasculitis

Question 25

non-blanching purpura classically of lower extremities/buttocks

Answer 25

Henoch-Schonlein Purpura

Question 26

antibodies that ppt from serum in cold , resolubilize upon warming

Answer 26

Cryoglobulins

Question 27

fever, weight loss, fatigue Palpable purpura with ulcers Digital ischemia

Answer 27

Cryoglobulinemia Vasculitis

Question 28

Giant cells eat up internal elastic lamina

Answer 28

GCA

Question 29

Granulomatous inflammation of AORTA and its branches Medial loss of elastic fibers → thinning → Aneurysm or dissection

Answer 29

Takayasu’s Arteritis

Question 30

strawberry tongue

Answer 30

Kawasaki Disease

Question 31

hypocomplementemia and ↑↑ANAs

Answer 31

Connective Tissue Disease Associated Vasculitis

Question 32

Pupuric lesions | Deep cutaneous ulcer over malleoli

Answer 32

Rheumatoid Vasculitis

Question 33

eosinophilic granulomas of the urinary tract and/or prostate

Answer 33

Allergic Granulomatosis With Polyangiitis [AGPA] (Churg Strauss Syndrome)

Question 34

Most commin in 20’s and 30’s | with oral or genital ulcers

Answer 34

Bechet’s Disease

Question 35

Adults: Usually following drug exposures (sulfas, penicillins, diuretics, allopurinol, phenytoin) Kids: UTR infections

Answer 35

Hypersensitivity Vasculitis

Question 36

↓C4

Answer 36

Cryoglobulinemia Vasculitis

Question 37

leukocytoclastic vasculitis with IgM + C3 deposits in/around small and medium sized vessels

Answer 37

Cryoglobulinemia Vasculitis

Question 38

Pathogenesis: Ag recognition in adventitia → IFN-γ →macrophages form giant cells→ arterial wall destruction + occlusive intimal hyperplasia

Answer 38

GCA

Question 39

erythema of palms/soles

Answer 39

Kawasaki Disease

Question 40

Jaw or tongue claudication

Answer 40

GCA

Question 41

Type of Igs in Cryoglobulinemia Vasculitis

Answer 41

IgG and M

Question 42

Necrotizing vasculitis affecting small vessels, but no granulomas

Answer 42

Microscopic Polyangiitis

Question 43

can progress to sudden blindness

Answer 43

GCA

Question 44

Testicular tenderness

Answer 44

Polyarteritis Nodosa

Question 45

Infectious causes og vasculitis Fungal =? Bacterial =? viral =?

Answer 45

``` Fungal = aspergillus Bacterial = pseudomonas viral = CMV ```