Vasculitis Flashcards
What are the immune complex mediated small vesselvasculitis diseases?
hypersensitivity vasculitis;
Henoch-Schonlein purpura;
cryoglobulinemic vasculitis
Define vasculitis
inflammation of blood vessels with necrosis of blood vessels walls, narrowing, and occlusion
How to classify vasculitis?
size of blood vessels involved, pattern of organ involvement, pathophysiology
Give the size of the blood vessel involvement
small=> capillaries/postcapillary venules
Medium=>muscular arteries and arterioles
large=>aorta and branches
What vasculitis disorders affect the aorta?
Giant cel arteritis
Takayasu’s arteritis
What vasculitis disorders affect large to medium sized arteries
Polyarteritis nodosa
Kawasaki disease
What vasculitis disorders affects the arteriole/capillary junction?
anti-GBM (Goodpasture’s disease)
What vasculitis disorders affect the capillary and venule?
leukocytoclastic vasculitis
What vasculitis disorders affect arterioles and venules?
Henoch Schonlein purpura;
cryoglobulinemic vasculitis
What vasculitis disorders affect small sized arteries to venules?
microscopic polyangitis
What vasculitis disorders affect small sized arteries to veins?
granulomatosis w/ polyangitis;
Churg-strauss syndrome
What connective tissue disorders are associated with IC-mediated vasculitis?
SLE;
Sjogren’s syndrome’
RA
What is the classic cutaneous finding in small vessel vasculitis?
palpable purpura
What typically causes hypersensitivity vasculitis?
a reaction to medication or infection
What are the clinical manifestations associated with hypersensitivity vasculitis?
purpura, arthritis, glomerulonephritis, colicky abdominal pain
IgA deposition w/in blood vessel walls
Differentiate cryoglobulinemic vasculitis and mixed cryoglobulinemia
CV=> long standing HCV infection
MCV=> immuno reactants involved include IgG and IgM
Define cryoglobulins
Abs that precipitate from serum under conditions of cold and resolubilize upon warming
What is characteristic of type I cryoglobulins
monoclonal, RF negative and associated w/ malignancies
cause hyperviscosity syndromes => NOT vasculitis
What is characteristic of type II and IIIcryoglobulins
polyclonal (IgG and IgM Abs) have RF activity;
RESULT IN IC-MEDIATED VASCULITIS
Which cryoglobulins are associated with hep C?
type II and III
Cutaneous vasculitis in connective tissue disorders are associated with what?
hypocomplementemia;
high titers of ANAs;
Biopsy shows IgG and C3 deposition
Why must rheumatoid vasculitis (RV) and periungual vasculitis be differentiated?
vasculitis-specific therapy
What sized vessels does RV associated with?
aggressively involves medium and small vessels
What is the primary difference in polyarteritis nodosa and RV?
microaneurysms are more common in PAN
