Vasculitis

Question 1

The clinical manifestations of vasculitis typically include constitutional signs and symptoms. What are they?

Answer 1

fever, myalgias, arthralgias, and malaise

Question 2

The two common pathogenic mechanisms of vasculitis

are _____________ and _______________.

Answer 2

Immune-mediated inflammation

Direct invasion of vascular walls by infectious pathogens

Question 3

Immunosuppressive therapy is useful for ________________ type vasculitis.

Answer 3

Immune mediated

Question 4

______________ therapy is harmful for infectious vasculitis.

Answer 4

Immunosuppressive

Question 5

What r the brief causes of vasculitis?

Answer 5

Physical or chemical injury (mechanical trauma, irradiation, toxins)

Question 6

The major cause of noninfectious vasculitis is a local or systemic ___________ response.

Answer 6

immune response

Question 7

What are the four causes of immunologic injury in vasculitis?

Answer 7

Immune complex deposition
Antineutrophil cytoplasmic antibodies
Antiendothelial cell antibodies
Autoreactive T cells

Question 8

Name some conditions in which immune complex-associated vasculitis is found.

Answer 8

SLE
Drug Hypersensitivity vasculitis
Vasculitis secondary to infections

Question 9

The vascular lesions resemble those found in experimental immune complex–mediated disorders, such as the ___________ and ____________

Answer 9

Arthus phenomenon

Serum sickness

Question 10

What is pauci-immune vasculitides?

Answer 10

Pauci-immune vasculitis is a form of vasculitis that is associated with minimal evidence of hypersensitivity upon immunofluorescent staining for IgG.

Question 11

What happens in drug hypersensitivity vasculitis?

Answer 11

Drugs bind to serum proteins or vessel wall constituents, antibodies are made against drug-modified proteins or foreign particles which form immune complex.

Question 12

Type of lesion found in drug hypersensitivity vasculitis is ________

Answer 12

skin

Question 13

Drug hypersensitivity vasculitis can be _________ to ___________ (mild to moderate/mild to fatal)

Answer 13

mild to fatal

Question 14

Is drug hypersensitivity vasculitis reversible if we withdraw the drug?

Answer 14

Yes

Question 15

In up to 30% of patients with polyarteritis nodosa, the vasculitis is attributable to immune complexes composed of ____________ and _____________

Answer 15

Hepatitis B surface antigens (HBsAg)

Anti-HBsAg antibody