Vasculitides Flashcards
giant cell (temporal) arteritis
- elderly F
- granulomatous
- inc ESR
- HA/jaw claudication
- pain on chewing
tx: high dose steroids ASAP to avoid blindness (ophthalmic a.)
takayasu arteriris
- young asian F
- granulomatous
- inc ESR
- granulomatous thickening of aortic arch/branches
- pulseless disease (weak UE pulses)
tx: steroids
kawasaki disease
- asian child
- skin/lips/tongue
- diffuse red rash
- palms/soles –> desquamate
- strawberry tongue
- conjunctival injections
- cervical lymphadenopathy
- fever
AE: coronary aneurysms
tx: IVIG, ASPIRIN
Buerger’s disease
“thromboangitis obliterans”
- male, smokers
- hand/foot gangrene
- Raynaud’s
tx: smoking cessation
polyarteritis nodosa
hep B associated
- immune complex mediated (HS III)
- MOST organs except lung (n., GI, skin, kidneys, vessel)
- aneurysms *renal
- string of pearls sign, fibrinoid necrosis
tx: corticosteroids, cyclophosphamide
Henoch-Schloein purpura
“IgA vasculitis”
- most comm child vasculitis
- follows URI
- triad=palp purpura on buttocks/legs, arthralgia, GI pain/melena)
dx: tissue biopsy
tx: usu self-limited
Wegener’s Granulomatosis
“granulomatosis w/ polyangitis”
- sinusitis/otitis media/hemoptysis (UPPER/LOWER AIRWAY)
- saddle nose
- hematuria/purpura/granulomas
c-ANCA
tx: steroids/cyclophosphamide
microscopic polyangitis
-sim to Werner’s (lung, kidney, but NO upper airway or granulomas)
p-ANCA
tx: steroids/cyclophosphamide
Churg-strauss
- asthma/sinusitis/neuropathy
- EOS
- granulomas, necrotizing vasculitis
- heart/GI/kidneys
tx: steroids/cyclophosphamide
hep B assoc
polyarteritis nodosa
hep C assoc
cyroglobulinemic vasculitis
cryoglobulins precipitate when cooled in vitro
IgG and IgM mixed
