Vascular Surgery Flashcards
How is ABPI calculated
Foot artery occlusion pressure / brachial systolic pressure
ABPI >1.1 indicates
Calcified or incompressible vessels e.g. diabetes and renal failure
ABPI 0.7-0.9 indicates
Mild ischaemia
ABPI 0.4-0.7 indicates
Moderate ischaemia
ABPI <0.4 indicates
Critical ischaemia
What is the most accurate investigation for imaging the arterial system
Intra-arterial digital subtraction angiography (IADSA)
What is the investigation of choice for imaging the lymphatic system
Lymphoscintigraphy
How is lymphoscintigraphy performed
Radiolabelled colloid is injected into the webspace between the 2nd and 3rd toes and images obtained with a gamma camera
What are the 3 histological layers of an artery
- Tunica intima
- Tunica media
- Tunica adventitia
What are the 2 types of artery
- Elastic conducting arteries
2. Muscular distributing arteries
Describe the tunica intima
- Innermost layer
- Single layer of endothelial cells orientated in the direction of flow
Describe the tunica media
- Middle layer
- Composed of elastin and collagen fibres with vascular smooth muscle cells
Describe the tunica adventitia
- Outermost layer
- Connective tissue
What are the histological differences between the thoracic and abdominal aorta
Thoracic aorta has >30% elastin compared to <20% in the abdominal section
What crosses the abdominal aorta anteriorly
- Splenic vein
- Body of pancreas
- 3rd part of duodenum
- Left renal vein
What lies immediately to the right of the abdominal aorta
- IVC
- Right ureter
- Azygous vein
What lies immediately to the left of the abdominal aorta
- Left sympathetic trunk
- Left ureter
Define an aneurysm
Pathological dilatation of an artery to >1.5x its normal diameter
What is the diameter of the aorta
2cm
Define a true aneurysm
Dilatation of an artery involving all layers of the arterial wall
Define a false aneurysm
Pulsatile, expansile swelling due to a defect in an arterial wall, with blood outside of the lumen, surrounded by a capsule of fibrous tissue or compressed surrounding tissue
List the causes of aneurysms
- Degenerative (atherosclerotic) - MOST common
- Inflammatory
- Congenital (Berry aneurysm)
- Mycotic (bacterial, IE)
- Infective
Where is the most common site of atherosclerotic AAA
Infrarenal
Mortality rate for elective AAA repair
5%
In whom is elective AAA repair offered
Those with a AAA >5.5cm
What percentage of AAAs involve the iliac arteries
30%
What percentage of AAAs are asymptomatic
75%
Where does a AAA typically rupture and what does this cause
- Posterior wall
- Retroperitoneal haematoma (bruising of the flanks/scrotum
Who is screened for AAA in the UK
65 year-old men
What histological changes are seen in AAAs of those with Marfan’s
Cystic medial necrosis
How much blood should be cross-matched for ruptured AAA repair
10 units
What type of AAA repair is preferred if there is iliac involvement
- Open
- Trouser Y-graft
List the immediate complications of AAA repair
- Primary Haemorrhage
- Distal embolisation (ischaemic leg, trash foot)
List the early complications of AAA repair
- Haemorrhage (reactionary, secondary)
- MI
- Renal failure (esp if proximal clamp above renal vessels)
- Multi-organ failure/DIC/ARDS
- Colonic ischaemia
- Pneumonia
- Stroke
- DVT/PE
- Paraparesis due to spinal ischaemia
How much heparin is to be used prior to cross-clamping of the aorta
3000 units
What bacteria cause myoctic aneurysms
- Staph aureus
- Salmonella
- Streptococcus
List the late complications of AAA repair
- Late graft infection
- Aortoenteric fistula
- Anastomotic aneurysm
What are the requirements of conventional EVAR
Aneurysm needs to have a proximal neck of at least 5mm above the aneurysm and below the renal arteries
What type of endovascular graft can be used in those aneurysms not suited for conventional EVAR
Fenestrated EVAR (very expensive)
What are the follow-up implications for EVAR
Long-term due to high risk of late complications e.g. endoleak
Describe type 1 endoleaks
Leak from stent-graft attachment site
Describe type 2 endoleaks
Leak due to retrograde flow through visceral or lumbar arteries into aneurysm sac (most common type)
Describe type 3 endoleaks
Due to structural failure of the stent-graft e.g due to holes
Describe type 4 endoleaks
Due to graft porosity and usually settles with time
Describe type 5 endoleaks
Aneurysm sac continues to expand with time, but no leak is identified (endotension)
What is the 2nd most common site of atherosclerotic aneurysm
Popliteal artery
How do popliteal aneurysms present
- Aneurysm thrombosis or distal emboli leading to limb ischaemia
- Rupture is rare
How are popliteal aneurysms treated
- Ligation and vein bypass graft, OR
- Endovascular stent
What percentage of those with a popliteal aneurysm will also have a AAA
30%
What is the most common type of visceral artery aneurysm
Splenic artery aneurysm
What are the indications for surgery in popliteal aneurysm
- Symptomatic
- Limb ischaemia
- Asymptomatic with thrombus
List the branches of the external iliac artery
- Inferior epigastric artery
- Deep circumflex iliac artery
List the branches of the femoral artery
- Superficial circumflex iliac artery
- Superficial epigastric
- Superficial and deep external pudendals
- Profunda femoris
Describe the course of profunda femoris
- Largest branch of the femoral artery
- Arises posteriorly/posterolaterally
- Descends medially to enter adductor compartment
- Gives of medial and lateral circumflex femoral, then 3 perforators
- Ends as 4th perforator
Outline the bounds of the popliteal fossa
- Lateral = biceps femoris above, lateral head of gastroc and plantaris below
- Medial = semimembranosus and semitendinosus above, medial head of gastroc below
- Floor = popliteal surface of femur, posterior ligament of knee, popliteus mucle
- Roof = superficial and deep fascia
What is the deepest structure of the popliteal fossa
Popliteal artery
What is the most superficial structure of the popliteal fossa
Tibial nerve
What flanks the dorsalis pedis artery in the foot
- Medial = EHL tendon
- Lateral = EDL tendons
What does the posterior tibial artery divide into
Medial and lateral plantar arteries
What is the most common caused of PVD
Atherosclerosis with thrombosis
Outline the structure of an atherosclerotic plaque
- Superficial fibrous cap
- Intra-intimal area with accumulation of lipids, smooth muscle cells, foam cells
- Basal zone with lipid accumulation and tissue necrosis
What is thromboangitis obliterans also known as
Buerger’s disease
What is the classic demographic of Buerger’s disease
Progressive obliteration of distal arteries in young men who smoke heavily
How is Buerger’s disease managed
- Smoking cessation
- Sympathectomy to relieve arterial spasm
- Antibiotics
- Foot care
- Analgesia
- Prostaglandins for acute ischaemia
List the symptoms of acute limb ischaemia
- Pain
- Pulseless
- Pallor
- Paraesthesia
- Paralysis
- Perishing cold
What is the time-frame for resolution of acute limb ischaemia
4-6 hours
Outline the principles of managing acute limb ischaemia
- Resuscitation
- Immediate anticoagulation (5000 units heparin IV)
- Analgesia
- Restore arterial continuity
- Identify and correct any underlying source of embolus
What is the investigation of choice in acute limb ischaemia if diagnosis in doubt
Arteriography
Describe the clinical appearance of a limb with <6 hours ischaemia
White
Describe the clinical appearance of a limb with 6-12 hours ischaemia
Mottled limb with blanching on pressure
Describe the clinical appearance of a limb with 12-24 hours of ischaemia
Fixed mottling
What is the preferred treatment for acute-on-chronic limb ischaemia
Thrombolysis
What are the contraindications to thrombolysis in acute limb ischaemia
- Extreme old age
- Recent surgery (2 weeks)
- Recent CVA (2 months)
- Peptic ulceration
- Bleeding tendencies
How should a white leg with sensorimotor deficit be managed
Surgery and embolectomy
How should a dusky leg with mild anaesthesia be managed
Angiography
How should a leg with fixed mottling be managed
Primary amputation
In those with acute limb ischaemia, when should fasciotomy be considered
If the time between onset and surgery exceeds 6 hours
What are the systemic effects of reperfusion injury
- Rhabdomyolysis
- Renal failure
- ARDS
- Myocardial dysfunction
- Clotting disorders
What are the early signs and symptoms of compartment syndrome
- Pain out of proportion to the condition/injury
- Pain on passive stretch
- Absent distal pulse
What are the late signs and symptoms of compartment syndrome
- Paralysis
- Weakness and tenderness
- Pale, cold limb
- Sensory loss
What incision is used for femoral embolectomy
Longitudinal incision in the groin below the inguinal ligament and over femoral artery
What incision is used for brachial embolectomy
Transverse incision below the skin crease at the elbow
What measures should be taken following surgery for acute limb ischaemia
- Check angiogram on table and prior to closure
- Systemic heparinisation should follow surgery which should later be converted to Warfarin
What type of catheter is used for embolectomy
Fogarty catheter
What type of fasciotomy should be performed in lower leg compartment syndrome
Four-compartment fasciotomy
Describe Leriche syndrome
Distal aortic/Proximal iliac stenosis/occlusion causing:
- Buttock, thigh and calf claudication
- Erectile dysfunction
- Proximal muscle wasting
Outline the implications of Buerger’s angles
- 50 degrees = severe ischaemia
- 25 degrees = critical ischaemia
Outline the assessment of PVD
- Clinical examination
- ABPI
- Duplex arterial USS
- Angiography (only if intervention is planned)
What PVD lesions are amenable to angioplasty
- Short lesion
- Reasonable distal runoff
- Better for proximal disease
What can be used to supplement vein grafts that are not long enough in bypass surgery
Miller Cuff (made from PTFE)
Why are PTFE grafts unsuitable for distal disease
Undergo subintimal hyperplasia early which leads to occlusion and graft failure
What suture is used for vascular anastomosis
Fine non-absorbable monofilament (e.g. 5/0 prolene)
What type of arteriotomy is used in Fem-pop bypass
Longitudinal arteriotomy
When is fem-fem crossover used
Unilateral iliac occlusive disease not amenable to angioplasty or stenting
When is axillo-bifemoral grafting used
Aortic or bilateral iliac occlusion not amenable to angioplasty or stenting, in the presence of a hostile abdomen, or in a patient not fit for major abdominal surgery
When is aorto-bifemoral grafting used
Occlusive or stenotic aorto-iliac disease not amenable to stenting or angioplasty
What is the most likely cause of mid-term (1 year) graft failure
Neointimal hyperplasia causing stenosis of the graft
What is the most likely cause of late graft failure
Atheromatous disease progression
What graft is typically used for PVD
Long Saphenous vein used in reverse
How much bone should ideally be conserved in BKA
15cm
What are the indications for amputation (3 D’s)
- Dead - non viable
- Deadly - tumour, severe infection
- Damn useless - pain, neurological damage
Describe a Gritti-Stokes amputation
- Supracondylar amputation preserving the patella
- Double amputees
What type of flaps are used in above knee amputation
Anterior and posterior semicircular skin flaps
What type of flaps are used in below-knee amputations
- Burgess flap - long posterior flap using posterior calf muscles to cover the bone ends 15cm below the tibial tuberosity
- Skew Flap (MOST POPULAR)
When is a trans-metatarsal amputation indicated
Diabetic gangrene of the forefoot
What is the general rule for flap length:diameter ratio in amputation
1.5x diameter
What type of prosthesis can aide early mobilisation in amputation
POMAID
Describe the appearance of a neuropathic ulcer
- Punched-out lesion
- Surrounded by a ridge of hard calloused skin
Define a Carcot’s joint
Painless, disorganised joint due to decreased pain sensation and proprioception
What proportion of strokes are caused by carotid artery disease
15%
Describe stroke presentation of the carotid territory
- Contralateral hemiparesis
- Dysphasia if dominant hemisphere
Describe stroke presentation of the vertebral hemisphere
- Vertigo
- Diplopia
- Blurred vision
- LOC
- Facial involvement
- Cerebellar signs
Who should be offered elective carotid endarterectomy
Patients with ipsilateral stenosis >70% that have caused symptoms in the previous 6 months
What is the GOLD standard assessment tool for carotid stenosis
Duplex doppler USS
What incision is used for carotid endarterectomy
Longitudinal incision at the anterior border of SCM
What nerves are at risk of damage in carotid endarterectomy
- Marginal mandibular
- Superior laryngeal
- Hypoglossal
- Great auricular
Histology of carotid body tumours
Paraganglionic cells of neural crest origin
Characteristic signs of carotid body tumours
- Mass adjacent to hyoid
- Smooth, compressible, pulsatile
- Red-brown appearance
What causes subclavian steal syndrome
Stenosis of the subclavian artery, proximal to the origin of the vertebral artery
What is the physiological result of subclavian steal syndrome
Any increase in the demand for blood to the arm causes reverse flow of blood from the cerebral circulation, through the vertebral artery, to supply the subclavian post-stenosis
What are the symptoms of subclavian steal syndrome
- Dizziness
- LOC
- Ataxia
- Visual loss
Explain the likely distribution of upper limb emboli
- 50% lodge in the brachial artery
- 30% lodge in the axillary artery
What are the sources of upper limb emboli
- Left atrium from AF
- Mural thrombus
Outline the management of upper limb emboli
- IV heparin
- Angiography/duplex
- Brachial embolectomy under GA
Describe the 3 clinical phases of Raynaud’s syndrome
- Digital blanching due to arterial spasm (white)
- Cyanosis/pain due to stagnant anoxia (blue)
- Reactive hyperaemia due to accumulation of vasoactive metabolites (red)
Drugs used to treat idiopathic Raynaud’s syndrome
- Nifedipine
- Prostacyclin
Where are the most common sites of hyperhidrosis
- Palms
- Axilla
- Feet
List the causes of secondary hyperhidrosis
- Hyperthyroidism
- Phaeochromocytoma
- Hypothalamic tumours
List the non-surgical interventions for hyperhidrosis
- Topical ammonium chloride
- Iontophoresis (elective current to incapacitate sweat glands)
- Botox (decreases sympathetic activity)
How is palmar hyperhidrosis treated surgically
- Laparoscope inserted into the pleural space via the axilla
- 2nd and 3rd thoracic ganglia are removed
Why is the first thoracic ganglia not removed in sympathectomy
Will cause Horner’s syndrome
What is the best treatment for axillary hyperhidrosis
Botox
How is plantar hyperhidrosis treated
Chemical lumbar sympathectomy
What must be divided to perform a thoracic sympathectomy
Parietal pleura
Define thoracic outlet syndrome
Compression of the subclavian branches of the brachial plexus as they pass from the thorax into the arm
List the causes of thoracic outlet syndrome
- Cervical rib
- Abnormal muscle insertions or muscle hypertrophy
- Fibrous band
- Callus from old clavicular fracture
- Neck trauma
- Malignancy
What test may precipitate symptoms of thoracic outlet obstruction
Roos’ test = abduction and external rotation of the arm may precipitate symptoms
How may thoracic outlet syndrome be surgically corrected
Decompression:
- Resection of 1st part of 1st rib
- Divide anterior scalene muscle
Where is upper limb venous occlusion likely to occur
- Axillary vein
- Subclavian vein
What is the investigation of choice for diagnosing axillary vein thrombosis
Duplex scan
What is the best treatment for axillary vein thrombosis
Local catheter directed TPA
Describe cervical rib
Elongation of the 7th cervical vertebrae transverse process
List the causes of congenital AV fistulas
- Cirsoid
- Parkes-Weber syndrome
- Klippel-Trenaunay syndrome
Describe a Cirsoid aneurysm
Localised arteriovenous fistula typically occurring in the scalp
Describe Parkes-Weber Syndrome
Congenital condition of multiple AV malformation associated with increased limb size, dilated superficial veins with ulceration, and high-output cardiac failure
Describe Klippel-Trenaunay syndrome
Combination of:
- Port-wine staining
- Varicose veins
- Hypertrophy of bony and soft tissues
- Improperly developed lymphatic system
List the deep veins of the leg
- Posterior tibial
- Anterior tibial
- Peroneal
- Soleal
- Gastrocnemius
List the deep veins of the thigh
- Popliteal
- Superficial femoral vein
- Deep (profunda) femoral vein
- Iliac
List the superficial veins of the lower limb
- Long saphenous
- Short saphenous
Where does the long saphenous vein communicate with the deep venous system of the leg
- Saphenofemoral junction
- Mid-thigh perforator
- Medial calf perforators (3 or 4)
Where does the short saphenous vein join the deep circulation
Enters popliteal vein after piercing deep fascia
Where does the short saphenous vein communicate with the deep venous system
- Popliteal vein
- Gastrocnemius communicating veins
- Lateral calf communicating veins
Most common site of varicose veins
Long saphenous system
Describe primary varicose veins
Form due to gravitational venous pooling and vein wall laxity causing venous dilatation and valve leakage
Describe secondary varicose veins
Caused by obstruction of deep venous outflow (e.g. DVT, pelvis malignancy) resulting in blood being forced to the superficial system
How may sites of venous incompetence be formally assessed
USS doppler
Define Saphena Varix
Reducible swelling in the groin due to a dilated varix at the saphenofemoral junction
List the indications for surgery to treat varicose veins
- Cosmetic (majority)
- Lipodermatosclerosis causing venous ulceration
- Recurrent superficial thrombophlebitis
- Bleeding from ruptured varix
List the surgical options for symptomatic uncomplicated varicose veins
- Endothermal ablation
- Foam sclerotherapy
- Saphenofemoral/popliteal disconnection
- Stripping and avulsions
What structures are at risk during long saphenous vein surgery
Saphenous nerve (sensory loss)
What structures are at risk with short saphenous vein surgery
- Sural nerve (sensory loss)
- Common peroneal nerve (foot drop)
Outline the two theories of venous ulcer formation
- Leucocyte trapping theory
2. Fibrin cuff theory
How are chronic venous ulcers managed
Class 2-3 compression stockings (ensure no arterial disease)
Describe 4-layer compression bandaging
- Cotton wool
- Crepe
- Elastic bandage
- Cohesive bandage
What parasite is responsible for filariasis
Wuchereria bancrofti (usually transmitted by mosquitos)
What does lymphoedema involve
- Accumulation of protein-rich fluid
- Subdermal fibrosis
- Dermal thickening
Where is fluid confined to in lymphoedema
Epifascial space (skin and subcutaneous tissues)
Cause of primary lymphoedema in those aged <1
Milroy’s disease (congenital)
Cause of primary lymphoedema in those aged 1-35
Meige’s disease
Cause of primary lymphoedema in those >35
Tarda
List the indications for surgery in lymphoedema
- Marked disability or deformity from limb swelling
- Lymphoedema caused by proximal lymphatic obstruction with patent distal lymphatics suitable for a lymphatic drainage procedure
- Lymphocutaneous fistulae and megalymphatics
How can the diagnosis of lymphoedema be confirmed
Lymphoscintigraphy
How can detailed anatomy fo the lymphatic system be detailed prior to lymphatic reconstruction
Lymphangiography
What procedure is indicated for those with proximal lymphatic obstruction and normal distal lymphatics
Lymphovenous anastamosis
Which procedure is indicated in lymphoedema with good overlying skin
Homan’s operation
Which procedure is indicated in lymphoedema with poor overlying skin
Charles operation