Vascular pathology part 3 (vascular tumors)

Question 1

The parents of a newborn are concerned about a large red mark that was present at birth and has not disappeared. Upon examination the tumor is determined to be benign. What is the tumor?

Answer 1

A benign hemangioma (made up of blood vessels)

Question 2

A patient presents with multiple masses on the skin, breasts, & liver. Biopsy shows the tumors are made of endothelial cells & highly aggressive/malignant, what is the diagnosis?

Answer 2

Angiosarcomas

Question 3

Patient works in a PVC & metal (arsenic) distribution center, they present to the clinic with multiple masses on the skin & breasts, What is the tumor & what’s it made up of?

Answer 3

Angiosarcoma which is made up of endothelial cells this cancer is very AGGRESSIVE

Question 4

A older male patient of European descent with a history of HHV-8, presents with purple patches/plaques, & nodules on the skin. What’s the likely diagnosis?

Answer 4

Kaposi Sarcoma, made up of endothelial cells

Question 5

Older Eastern European males
AIDS patients
Transplant recipients

Are all at higher risk of developing which type of tumors?

Answer 5

Kaposi sarcoma

Question 6

A benign but very painful tumor typically found under the nail bed (subungual) or on the dorsal surface of the hand

Answer 6

Glomus tumor

Question 7

What cells are glomus tumors made out of

Answer 7

smooth muscle cells that are originally involved in temperature regulation & AV shunting

Question 8

Nests of round regular smooth muscle cells with connective tissue, they’re associated with branching vascular spaces

Answer 8

Glomus tumor

Question 9

Sheets of spindle endothelial cells that create slit-like capsular channels, it’s associated with an infection

Answer 9

Kaposi’s sarcoma associated with HHV-8 usually seen in immunodeficient patients (AIDs, Diabetes, Transplant patients)

Question 10

Purple/brown/red lesions that don’t blanch & eventually ulcerate, ass with HHV-8

Answer 10

Kaposi sarcoma

Question 11

A fatal sarcoma of the liver

Answer 11

Angiosarcoma, very malignant usually in people exposed to PVC, arsenic, or thorotrast

Cells are CD31 +ve