Vascular Disease

Question 1

Cavernous malformations: Prevalence

Answer 1

0. 5%

0. 5 / 100, 000 / year

Question 2

Cavernous malformations: What are the 3 autosomal dominant familial forms?

Answer 2

CCM 1
CCM 2
CCM 3

Question 3

Cavernous malformations: Familial form is prevalent among what ethnicity?

Answer 3

Hispanic population

Question 4

Cavernous malformations: Most common presentation symptoms

Answer 4

Seizures (50%)
Focal deficit (25%)
Incidental
Headaches

Question 5

Cavernous malformations: Risk of hemorrhage

Answer 5

0.5-2% / year

Question 6

Cavernous malformations: Who have higher risk of hemorrhage?

Answer 6

Previous hemorrhages (5% / year)
Deep lesions (10% / year)
Posterior fossa lesions
Familial inheritance
Women (4% / year)

Question 7

Cavernous malformations: Treatment

Answer 7

Observation/medical tx for seizures
Surgical excision - good outcome in 90%

Radiosurgery does not alter radiographic appearance and does not alter natural history