Vascular Flashcards
You are asked by your colleague to see an elderly patient in clinic who has a
positive Buerger’s test. From the list of options below, select the most likely reason
for a positive Buerger’s test.
A. Venous insufficiency of the upper limbs
B. Arterial insufficiency of the lower limbs
C. Venous insufficiency of the lower limbs
D. Arterial insufficiency of the upper limbs
E. None of the above
B. Arterial insufficiency of the lower limbs
Buerger’s test involves lifting the legs of the supine patient to 45degrees above the horizontal, the legs are kept here to observe for developing pallor (around 2 minutes). If pallor appears rapidly this is a por sign of diminished arterial supply.
After 2 minutes the legs are dropped off the side of the bed and blood returns via venous filling, the rate of which is observed.
If there is arterial insufficicy on one side this side will develop a reactive hyperaemia (this is a dusky crimson colour). This is arterial vasodilation due to anaerobic metaolites. A positive finding in both legs will only be apparent if the legs are carefully inspected at the start of the test.
Not to be confused with Buuerger’s disease (thromboangitis obliterans)
You are asked to see a 67-year-old woman admitted with severe limb ischaemia. Your senior colleague asks you to examine the patient and report your findings. What are the two most likely clinical features that suggest the patient has severe limb ischaemia?
A. Pulselessness and pain
B. Paraesthesia and paralysis
C. Perishingly cold limb and pallor
D. Pallor and pain
E. Paraesthesia and pallor
B. Paraesthesia and paralysis
The six P’s of acute limb ischaemia are;
- Pallor
- Perishingly cold
- Pain
- Pulseless
- Paraestesia
- Paralysis
Neurological deficit (parastesia and paralysis) are late signs as the ischaemia is severe enough to start killing nerves, urgent surgical intervention is indicated here.
Acute limb ischaemia is caused mainly by a Thrombus (40%) or an Embolus (38%). Other causes include a graft/angioplasty occlusion (~15%) or trauma
As part of the peripheral vascular examination, you are asked to record the
ankle–brachial pressure index of the patient. Which one of the following values
reflects a normal ankle–brachial pressure index?
A. Between 0.9 and 0.6
B. Greater than 1.3
C. Between 0.6 and 0.3
D. Greater or equal to 1.0
E. Less or equal to 0.3
D. Greater or equal to 1.0
The ABPI (ankle brachial pressure index) is a ratio of the arterial pressure at the ankle divided by the pressure at the upper arm. The Brachial pressure is measured using a manual sphygmomanometer at the upper arm and a doppler probe at the brachial artery.The anle pressure is measured with the cuff over the calf and the probe over the dorsalis pedis and then posterior tibial arteries (the higer reading is used).
By deviding the ankle blood pressure over the bracial we devise the ABPI, due to the greater vascular resistance in the leg (greater distance from the heart) the blod pressure should be slightly higher to maintain the same perfusion. As such the ABPI should be equal to or greater than 1.
a ratio of 0.9-0.6 [A] suggests peripheral vascular occlusive disease. eg intermittant claudication
a ratio of 0.6-0.3 [C] is moe suggestive of critical limb ischaemia
a ratio of less than 0.3 [E] implies impendng gangrene
a ratio greater than 1.3 [B] implies that the femral arteries are somewhat incompressible, likely due to calcification.
A 55-year-old man, with a positive smoking history, presents to you in outpatient clinic with pain in the lower leg which is brought on by walking. The pain is cramping in nature, well localized to the left calf only, and is relieved by rest. The patient has noticed that his walking distance has progressively decreased because of the cramps in the left calf. There are no abnormal findings on physical examination. What is the most appropriate way to investigate the patient’s symptoms?
A. Measure the ankle–brachial pressure index
B. Angiography
C. Radiograph of the lower limbs
D. Ultrasound
E. None of the above
A. Measure the ankle–brachial pressure index
Peripheral vascular disease commonly affects the abdominal aorta and lower limb arteries. This becomes critical in 50% of the vessel diameter or 75% of the cross sectional area is occluded. At this point the metabolic demands of the limbs cannot be met and ischaemia occurs, in intermittent claudication this occurs during exercise and resolves when resting.
This cramp like pain is experienced in the buttock, thigh or calf depending on the level of the occlusion.
ABPI is the first line diagnostic investigation for chronic limb ischaemia.
Ultrasound (D) may detect stenosed areas but provides no measure of phsiological impairment.
A radiograph (C) may not show anything abnormal
Angiography (B) is used to aid surgical or interventional planning, it is not first line.
A 60-year-old woman has been diagnosed as having claudication of the lower
limbs. The patient is a smoker and has hyperlipidaemia for which she is taking a ‘statin’. You are asked to discuss with the patient the treatment options available to her. From the list below, choose the recommended treatment option for this patient.
A. Angioplasty
B. Amputation
C. Thrombectomy
D. Increasing exercise and quitting smoking
E. Continue with the cholesterol-lowering medication and follow up in
outpatients in 3 months
D. Increasing exercise and quitting smoking
As with all medicine, there are stages of treatment; Expectant, lifestyle (conservative), best medical, interventional, and best surgical.
in the case of this patientshe has obvious lifestyle risk factors that can be addressed so this should be the aproach rather than expectant (E)
Smoking is a huge risk for vascular disease and increasing exercise will promote formation of a collateral supply, making (D) the best first step in management.
If that fails or the disease progresses then a more risky interventional treatment such as angioplasty (A) and Thrombectomy (C) can be considered.
The sugical option of amputation (B) is the last available option
You are told by your colleague that a 44-year-old woman, who underwent elective right hip replacement, is suspected of having deep vein thrombosis of the left calf. You are asked to carry out a pretest clinical probability score (Wells score) and a D-dimer test. Which is the most likely scenario where deep vein thrombosis can be excluded from your list of differential diagnoses?
A. Wells score of 4 and a positive D-dimer result
B. Wells score of 2 and a negative D-dimer result
C. Wells score of 0 and a negative D-dimer result
D. Wells score of 3 and a positive D-dimer result
E. None of the above
B. Wells score of 2 and a negative D-dimer result
Venous thrombosis forms due to one of the factors described by Virchow in his triad; Venous stasis, vessel wall damage, and a hypercoaguble state.
In clinical parctice these equate to the following risk factors; Age over 40, pregnancy, obesity, OCP use, clotting abnormalities, malignancy, recent pelvic or orthopaedic surgery, trauma, immobility, long-haul flights, and failure to provide DVT prophylaxis.
This question requires a bit of logic, given the low specificity of the D-dimer you would (should) only order it for patients with an intermediate risk of DVT (a wells score of 1-2), a negative D-dimer would rule ot a DVT in that case (B)
a high wells score (3+) is treated as suspected DVT and a duplex or compression ultrasound performed, no D-dimer is requested (A) or (D).
A Wells score of 0 or less is a low probability and so no D-dimer would be performed, making (C) an improbable scenario
A 65-year-old man presents for the first time to your clinic with a painless wound in his right leg, which has been present for over 2 months. On examination you notice a 3 cm x 4 cm leg ulcer in the gaiter area of the right leg, covering the medial malleolus. The shallow bed of the ulcer is covered with granulation tissue, which is surrounded by sloping edges. There is no history of trauma. From the list below, choose the most likely diagnosis.
A. Arterial leg ulcer
B. Neuropathic ulcer
C. Venous ulcer
D. Traumatic ulcer
E. Neoplastic ulcer
C. Venous ulcer
Venous ulcers tend to be painless, with sloped edges, in the gaiter area, larger, shallow and there tends to be skin changes such as haemosiderin deposition.
(A) an arterial ulcer would be very painful and would be small and ‘punched out’, it would also likly be on a pressere site (heel or toes). The base tends to be non granulated, and necrotic. There is often a loss of hair, pale brittle skin and erythema.
(B) There is an overlap with peripheral arterial disease and diabetes. They usually appear punched out of the surrounding callous of high pressure sites. They are often painless and the patient may not have noticed them.
(D) There is no history of trauma in this case.
(E) malignant ulcers may be primary or secondary, there is no indication of a malignant process here.
Your colleague consults you with regard to a 56-year-old patient who has suffered an episode of amaurosis fugax. From the list below, choose the most likely site of pathology which may give rise to amaurosis fugax.
A. Vertebrobasilar artery territory
B. Carotid artery territory
C. Posterior communicating artery territory
D. Spinal artery territory
E. Anterior communicating artery territory
B. Carotid artery territory
Amaurosis fugax means fleeting blindness and is often described as a dark curtain falling on the vision, it is unilateral. It occurs when an athrogenic emboli breaks off in the carotid and obstructs the lumen of the retinal artery circulation leading to ischaemia.
Other causes of amaurosis fugax incude cardiac emboli, temporary vasospasm of the retinal artery, atherosclerosis of the retinal artery or giant cell arteritis (leading to chronic granulomatous inflamation).
You have decided to investigate the symptom experienced by the patient in Question 8 (Amaurosis fugax). From the list below, select the most appropriate investigation that you would order first to investigate the site of pathology.
A. Magnetic resonance angiography
B. Digital subtraction angiography
C. Computed tomography scan of the head and neck
D. Duplex ultrasound scanning
E. None of the above
D. Duplex ultrasound scanning
Amaurosis fugax is strongly associated with carotid artery disease, such as atherosclerosis. The best modality for investigating this would be a duplex of the carotids.
DSA (B) is more invasive and expensive so is not preferred as an initial investigation, although it is gold standard for assesment of the grade and severity of stenosis.
MRA (A) is sometimes used after duplex
CT (C) doesn’t adequately visualise the pathology
You are told that a 45-year-old woman, who presented to the vascular surgery
clinic, has a positive tourniquet test in the left leg. On the basis of the information conveyed to you, from the list below, choose the most likely diagnosis that is associated with a positive tourniquet test.
A. Varicose veins
B. Chronic leg ischaemia
C. Deep vein thrombosis
D. Arterial ulcer
E. Acute leg ischaemia
A. Varicose veins
The tourniquet test is a modified Trendelenburg test. In this test the Sapho-femoral junction is occluded by a tourniquet.
First the patient lies on the couch and the affect leg is elevated and the varicosities are emptied by ‘milking’. with the leg still elevated the tourniquet is applied high on the thigh. The patient then stands and the rate at which the varicosities fill is assessed, if they fill rapidly the defect must be below the tourniquet, and vice versa.
You are in the vascular surgery outpatient clinic explaining the indications for
undergoing carotid endarterectomy to a patient. From the list below, select the
most likely scenario where carotid endarterectomy is likely to be indicated.
A. Symptomatic carotid artery stenosis of between 50 per cent and 60 percent
B. Asymptomatic carotid artery stenosis of between 70 per cent and 80 percent
C. Asymptomatic carotid artery stenosis of between 50 per cent and 60 percent
D. Symptomatic carotid artery stenosis of between 70 per cent and 80 percent
E. None of the above
D. Symptomatic carotid artery stenosis of between 70 per cent and 80 percent
Patients with symptomatic (TIA, Amaurosis fugax) stenosis of 70-80% have been identified in studies as good cadidates for carotid endarterectomy, providing they are otherwise fit and well.
Given the morbidity/mortality rate for this procedure (5%), it is not advised to offer this procedure to a patient with a 70-80% stenosis in the abscence of symptoms (B) and certainly not in a less significant stenosis (C)
A symptomatic patient with a 50-60% stenosis (A) is usually put on best medical therapy as a first line.
You see a 65-year-old man in your clinic, who is being monitored for an abdominal aortic aneurysm. The patient smokes 20 cigarettes a day and has a 25-year history of poorly controlled hypertension. From the list below, select the most appropriate investigation that can be used to monitor the progression of this patient’s condition.
A. Computed tomography scan of the abdomen
B. Angiography
C. Abdominal plain film radiography
D. Magnetic resonance imaging
E. Ultrasound
E. Ultrasound
An aneurysm is defined as the dilitation of an artery to >150% of its origional size. With a true aneurysm involving all layers of the vessel wall and being defined as fusiform (essentially uniform enlargement) or saccular (a berry aneurysm).
A psudoaneurysm doesn’t involve all the layers, it is where blood leaks between the layers and forms a haematoma leading to a dilatation of the vessel but not the lumen.
For the purposes of screening and monitoring a sub-threshold AAA (less than 5.5cm) ultrasound is the tool of choice. Should surgical intervention become necessary then a CT scan will be invaluable fo planning any procedure and creating a 3d model of the anatomy.
An abdominal plain film lacks sensitivity
angiography is invasive and carries risk
MRI is more expensive and less accessable than ultrasound which makes it less useful as a screening and assessemnt tool.
During a ward round you are asked about the conditions that must be met in order to qualify a patient for elective abdominal aortic aneurysm repair. From the list below, select the most likely abdominal aortic aneurysm size that warrants elective repair providing the patient is fit for surgery.
A. Greater than 5.0 cm
B. Greater than 5.5 cm
C. Less than 5.0 cm
D. Greater than 4.5 cm
E. Less than 5.5 cm
B. Greater than 5.5 cm
The qualifying criteria for repair of a AAA is that it has to be greater than 5.5cm (and the patient is fit for surgery).
Aneurysms less than 5.5cm are usually monitored with yearly ultrasound scans. those aneurysms greater than 5cm expand by 4-6mm per year on average, which is faster than smaller aneurysms.
Other indications for surgical repair other than pure size include; expansion rate greater than 1cm per year, symptomatic (back pain, distal embolisation), or tenderness.
Any sudden onset back pain and signs of hypoolamia indicates the need for emergency repair, this procedure has a 50-75% mortality, which is better than the certainty of death with no intervention.
A 41-year-old woman, diagnosed with varicose veins in the left leg, presents to
your clinic with a 2-month history of severe pain in the left leg on prolonged
standing. The patient is obese and the pain has affected her working and social lifestyle and she asks you about the most effective treatment option. From the list below, choose the most effective treatment option that you would discuss with this patient.
A. Use of compression stockings
B. Injection sclerotherapy
C. Surgery
D. Weight loss
E. None of the above
C. Surgery
Although in this case the patient’s symptoms would be improved by lifestyle measures, the question asks for the most effective treatment given the detrimental affect on function. Given that, the answer is surgery as this is the most effective treatment.
Weight loss will aid in the prevention of reccurrence and will help symptoms.
injection sclerotherapy can prove effective but surgery is the most effective treatment.
A 55-year-old woman, who is obese and has a positive smoking history, is to have varicose vein surgery in the next 12 hours. Your senior colleague asks you to ensure that deep vein thrombosis prophylaxis is commenced. From the list below, choose the most appropriate form of deep vein thrombosis prophylaxis that you would use.
A. Low-molecular-weight heparin
B. Warfarin
C. Aspirin
D. Clopidogrel
E. None of the above
A. Low-molecular-weight heparin
LMWH is an effective DVT prophylaxis in those patients about to undergo surgery.
Warfarin has a prothrombotic effect within the first 48hrs and takes up to 72hrs to be effective.
Aspirin and clopidogrel are anti-platelet drugs and so are more effective in arterial thrombos prophylaxis.