Valvular Heart Disease Flashcards
What are the most common conditions encountered today?
Degenerative (senile calcifications)
Myxomatous degeneration (MVP)
Congenital (bicsupid aortic valve)
What is stenosis
Impeding of forward flow
Stenotic, sclerotic fibrosis, calcification
leads to pressure overload; hypertrophy and HF
What is regurgitation
Failure to close adequately (leaks)
Causes a reversal of flow, insufficiency, incompetence, leads to volume overload; dilates
Implies insufficiency (aka)
Discuss the mechanism of acquisition for VHD what is the difference between acute and chronic disease
Congenital, acquired
Acute they decompensate very rapidly
Chronic slow breakdown of the valve
Rheumatic Heart disease
Caused by Group A strep infection (pharyngitis)
Jones major criteria- carditis- inflammation of heart muscle
Migratory polyarthritis (large joints) knees and hips
SubQ nodules (painless, over bone and tendon)
Chorea
Erythema Marginatum
What is the Jones Minor Criteria
Fever, Arthralgia, Increased Sed rate or CRP, Leukocytosis, ECG- prolonged PR internal
Elevated ASO titer or anti- DNAse B
How do you Dx rheumatic fever
Two major criteria or one major and two minor criteria
Discuss Mitral Stenosis including it’s subsequent LAE and RVH. What determines severe stenosis
Normal mitral orifice 4-6 cm.
Narrowing leads to increased left AV pressure gradient and RVH. 1 cm or less is considered severe
When does MS sx start to occur? and what are those sx?
4th decade of life, DOE, cough, orthopnea, PND, pulmonary edema, hemopytsis, arterial emobli, a fib
Ortner syndrome: Hoarseness d/+ compression of left recurrent laryngeal nerve
What will you find on physical exam of MS
Malar flush- ruddy cheeks, blue facies. Increased S1; opening shape (OS) after S2
Rumbling, diastolic murmur- low pitched; best heard at apex. Use Bell
What is the Tx of MS
AC if in A fib,
Percutaneous balloon valvuloplasty; MVR (replacement)
Possible RVF
What could pt’s develop progressive sx leading to RVF
Increased LA pressure, pulmonary HTN, pulmonary edema, hepatomegalia, ascites, peripheral edema
What is the trademark of Left atrial enlargement on ECG
Notched P in I
Biphasic P wave in V1
What are some etiologies of chronic MR?
MVP- most common
MAC( mitral annlar calcification)
What are some acute causes of mitral regurgitation?
Rupture of chordal tendineae
Rupture of papillary muscle
Ischemic papillary muscle dysfunction (CAD/MI: next most common of MR) Infective endocarditis (IE); valve perforation
What is the pathophysiology of MR (acute and chronic)?
Acute Increased LA pressure abruptly; pulmonary edema, LVF
Chronic- generally well compensated
What are some MR symptoms?
Asymptomatic for years-> fatigue, DOE
Acute; Volume overload/ orthopnea, PND, RHF/LHF
What would you find on physical exam for MR
Systolic mumur (blowing, prominent at apex; radiates into left axilla)
Loudness of murmur correlates with severity
Decreased S1 or normal; may have a systolic click
What is the tx of MR?
Vasodilators- to reduced afterload
Decrease resistance to flow
ACEi- chronic MR
What is MVP, who is more likely to get it? Are there any associated congenital conditions with this condition?
One or both mitral leaflefts will prolapse into LA during systole to cause MR
7:1 ratio female associated with Marfans/skeletal changes
What are the symptoms of MVP?
Asymptomatic to arrhythmias (SVT, PVC’s, VT), chest pain, syncope
Systolic murmur, may have systolic click
Rx. If hyper adrenergic state (anxious, palpitations, consider B-blockers)