Valvular Heart Disease Flashcards
What causes S1 sound?
Closure of mitral and tricuspid valves
What causes S2 sound?
Closure of aortic and pulmonic valves
What might an S3 heart sound suggest?
Congestive heart failure
What might an S4 heart sound suggest?
Poor ventricular compliance
Location for auscultating aortic valve sounds?
Right sternal border at 2nd intercostal space
Location for auscultating pulmonic valve sounds
Left sternal border at 2nd intercostal space
Location for auscultating mitral valve sounds
Left midclavicular line at 5th intercostal space
Location for auscultating tricuspid valve sounds
Left sternal border at 4th intercostal space
Heart sound that marks onset of systole
S1
Heart sound that marks the onset of diastole
S2
Heart sound that marks beginning of isovolumic contraction
S1
Heart sound that marks beginning of isovolumic relaxation
S2
Heart sound is louder with vigorously contracting ventricle
S1
Heart sound is softer with poorly contracting ventricle
S1
Heart sound is louder with hypertension
S2
Heart sound is softer with hypotension
S2
When is S3 heard?
During middle 1/3 of diastole- after S2
What causes S4 heart sound?
Atrial systole
When is S4 heard?
Before S1
What part of the stethoscope is best for listening to high pitched sounds (S1, S2, regurgitation)?
Diaphragm
What part of the stethoscope is best for listening to low pitched sounds (S3, S4, mitral stenosis)?
Bell
What type of valvular lesion results in concentric hypertrophy?
Stenosis
Valvular, fixed obstruction to forward flow
Stenosis
Valvular lesion- turbulent blood flow, higher velocity of travel
Stenosis
Cardiac compensation in which sarcomeres are added in a parallel fashion and the wall chamber becomes thicker > reduces chamber radius
Concentric hypertrophy
Incompetent valve
Regurgitation
Valvular lesion- some blood flows forward and some blood flows backward
Regurgitation
Valvular lesion- volume overload
Regurgitation
Heart compensates by adding sarcomere in series > chamber radius increases
Eccentric hypertrophy
Normal aortic valve area
2.5- 3.5 cm2
Aortic valve area in severe aortic stenosis
≤0.8 cm2
Etiologies of aortic stenosis
Bicuspid aortic valve
Rheumatic fever
Infective endocarditis
Compensatory mechanisms of aortic stenosis
Increased thickness of the left ventricular wall
Decreased compliance
Smaller chamber radius
Presentation of aortic stenosis
Syncope
Angina
Dyspnea
Anesthetic goals for aortic stenosis
HR: Avoid tachycardia
Rhythm: NSR (maintain atrial kick)
Preload: Increase
Afterload: Maintain or increase
Contractility: Maintain
Pulmonary vascular resistance: Normal
Anesthetic considerations for aortic stenosis
Avoid spinal anesthesia in patients with severe aortic stenosis
Chest compressions often ineffective
Arterial waveform of aortic stenosis
May show:
Pulsus tardus
Pulsus parvus
Transvalvular pressure gradient in aortic stenosis
> 40 mmHg
Wall tension in aortic stenosis (increased or decreased)
Increased
EDV and ESV in aortic stenosis (increased or decreased)
Increased
What valvular lesion does the pressure volume loop represent?
Aortic stenosis
What is pulsus tardus?
Slower systolic upstroke on arterial waveform
What is pulsus parvus?
Narrow pulse pressure with small amplitude waveform on arterial line tracing
Effects of aortic insufficiency on the left ventricle
Volume overload
Eventual eccentric hypertrophy
Etiologies of aortic regurgitation
Incompetent valve
Dilation of the aortic root/ supporting structures
What conditions should be avoided in aortic regurgitation?
Bradycardia
Increased SVR
Large valve orifice
How is cardiopulmonary bypass approach different in patients with aortic regurgitation?
Cardioplegia must be injected retrograde (through coronary sinus) or directly into each coronary ostia
What are causes of acute aortic insufficiency?
Endocarditis (most common)
Aortic root dissection from aneurysm or trauma
What is the pathophysiology of acute aortic insufficiency?
LV becomes acutely dilated > increased wall tension > LV failure > rapid cardiovascular instability
What conditions are associated with aortic insufficiency?
Valvular calcification
Marfan syndrome
Ehler-Danlos syndrome
Ankylosing spondylitis
Heart rate goal for aortic insufficiency
Increased
Preload goal for aortic insufficiency
Maintain/ increase
Contractility goal for aortic insufficiency
Maintain
SVR goal for aortic insufficiency
Decrease
Pulmonary vascular resistance goal for aortic insufficiency
Maintain
What valvular lesion is associated with a sharp upstroke, low diastolic pressure, and wide pulse pressure on the arterial waveform?
Aortic insufficiency
What valvular lesion may have this arterial waveform tracing?
Aortic insufficiency
What valvular lesion may have this arterial waveform tracing?
Aortic stenosis
What valvular lesion does the pressure volume loop represent?
Chronic aortic regurgitation
What valvular lesion does the pressure volume loop represent?
Mitral stenosis
Normal area of the mitral valve orifice
4-6 cm2
Area of mitral valve orifice in severe mitral stenosis
<1 cm2
Quantitative indications of severe mitral stenosis
Transvalvular pressure gradient >10 mmHg
Pulmonary artery systolic pressure >50 mmHg
Most common causes of mitral stenosis
Rheumatic fever (developing nations)
Endocarditis (United States)
Calcification of the mitral annulus secondary to atherosclerosis (United States)
Etiologies of mitral stenosis
Rheumatic fever
Endocarditis
Calcification of the mitral annulus secondary to atherosclerosis
Rheumatic arthritis
Systemic lupus erythematosus
Congenital defect
Left atrial myxoma
Carcinoid syndrome
Iatrogenic following mitral valve repair
What valvular lesion does the pressure volume loop represent?
Mitral stenosis
The image depicts the pathophysiology of which valvular lesion
Mitral stenosis
Heart rate goal for mitral stenosis
Slower end of normal
Preload goal for mitral stenosis
Maintain
Contractility goal for mitral stenosis
Maintain
SVR goal for mitral stenosis
Maintain
Pulmonary vascular resistance goal for mitral stenosis
Avoid increase
Regional anesthesia considerations for mitral stenosis
Pts are prone to atrial fibrillation and may be anticoagulated. Avoid neuraxial anesthesia in pts with INR >1.5
What valvular lesion does the pressure volume loop represent?
Chronic mitral regurgitation
The image depicts the pathophysiology of which valvular lesion
Mitral regurgitation
Etiologies of mitral insufficiency
Rheumatic fever
Ishcemic heart disease
Papillary muscle dysfunction
Ruptured chordae tendineae
Endocarditis
Mitral valve prolapse
Left ventricular hypertrophy
Systemic lupus erythematosus
Rheumatoid arthritis
Carcinoid syndrome
Mitral insufficiency results in:
Volume overload
Eccentric hypertrophy (left atrium)
Conditions to avoid in mitral insufficiency
Slow heart rate
Increased pressure gradient between the LV and LA
Increased SVR
Increased size of valve orifice
Heart rate goal in mitral insufficiency
Increased (NSR)
Preload goal in mitral insufficiency
Maintain or increase
Contractility goal in mitral insufficiency
Maintain
SVR goal in mitral insufficiency
Decrease
Pulmonary vascular resistance goal in mitral insufficiency
Avoid increase
Systolic murmurs
Aortic stenosis
Mitral regurgitation
Diastolic murmurs
Aortic regurgitation
Mitral stenosis
Characteristics of aortic stenosis assessment
Auscultated at right sternal border through aorta and carotid arteries
May be confused with bruit
May be palpated as a thrill
May decrease with severity
Characteristics of aortic regurgitation assessment
High pitch blowing murmur
Auscultated at right sternal border
Characteristics of mitral stenosis assessment
Opening snap followed by low intensity rumbling murmur
Auscultated at the apex and left axilla
Characteristics of mitral regurgitation assessment
Holosystolic murmur- loud swishing sound
Auscultated at apex and left axilla
The three surgical approaches for transcatheter aortic valve replacement
Transfemoral
Transaortic
Transapical (antegrade)
Benefits of transcatheter aortic valve replacement
Sternotomy not required
Cardiopulmonary bypass not required
Most common valves used for transcatheter aortic valve replacement
Edwards SAPIAN
Medtronic CoreValve
Type of artificial valve that requires balloon valvulosplasty
SAPIAN
Type of artificial valve that requires rapid ventricular pacing
SAPIAN
Considerations for rapid ventricular pacing
Profound hypotension during pacing
Ensure MAP >75 mmHg before pacing
Have radiotranslucent pads on pt prior to pacing
Keep pt apneic during pacing
Self-expanding artificial valve
CoreValve
Improper artificial valve deployment symptom
Acute aortic insufficiency
Surgical treatment for improper artificial valve deployment
SAPIAN- place another SAPIAN valve through malpositioned valve (valve-in-valve procedure)
CoreValve- retrieve and redeploy
Complications fo transcatheter aortic valve replacement
Vascular injury (hemorrhage)
Coronary occlusion
Annular rupture (cardiac tamponade> cardiovascular collapse)
Stroke
Perivalvular leak
Pericardial tamponade
AV block
LBBB
3rd degree block if pt has preexisting RBBB