Valvular Disease Flashcards

1
Q

Why does rheumatic fever contribute to valve disease?

A

Inflammation caused by rheumatic fever is resolved with scarring and laying down of fibrous tissue, increasing the likelihood go bacteria attaching and forming a vegetation

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2
Q

What does a tapping apex beat indicate?

A

Mitral stenosis

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3
Q

What does a diffuse apex beat indicate?

A

Left sided failure and cardiomyopathy

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4
Q

Which 5 features should you use to describe murmurs?

A

1) Intensity (according to Levine’s grading)
2) Timing, eg. early, late or mid systolic/diastolic, pansystolic, holosystolic
3) Character & pitch (quality - plateau, crescendo etc; high/low pitch; blowing/rumbing character)
4) Location
5) Radiation

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5
Q

Mid-systolic ejection murmur, heard best over the aortic area, with radiation into the carotid, particularly on the right

A

Aortic stenosis

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6
Q

High pitched early diastolic decrescendo murmur a with soft blowing character the left sternal edge with no radiation

A

Aortic regurgitation

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7
Q

Mid-diastolic decrescendo murmur with low pitched rumbling/tapping character heard best over the apex with no radiation

A

Mitral stenosis

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8
Q

Pansystolic murmur with blowing character heard best in the apex which radiates to the axilla

A

Mitral regurgitation

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9
Q

Pansystolic murmur heard best at the left lower sternal border

A

Tricuspid regurgitation

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10
Q

Which underlying conditions predispose to infective endocarditis?

A
  • Valvular heart disease, with stenosis or regurgitation (e.g calcifications or post rheumatic fever)
  • Valve replacement surgery
  • Structural congenital heart disease
  • IV drug abuse
  • Invasive vascular procedures such as intravascular lines
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11
Q

Which antibiotics should be used for streptococci viridians?

A

Benzylpenicillin + Gentamicin IV

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12
Q

Which antibiotics should be used for enterococcus faecalis?

A

Amoxicilin/Vancomycin + gentamicin IV

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13
Q

Which antibiotics should be used for staph aureus?

A
Flucloxacillin IV (non MRSA)
Vancomycin IV + rifampicin PO (MRSA)
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14
Q

Which antibiotics should be used for staph epidermis?

A

Vancomycin + gentamicin IV + rifampicin PO

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15
Q

What is a cardiac murmur?

A

Audible turbulence of blood flow

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16
Q

What is the most common value lesion?

A

Aortic stenosis

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17
Q

What are the main underlying causes of aortic stenosis?

A

Degenerative process (age related) or congenital eg. bicuspid valve (2 cusps rather than 3) or rheumatic

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18
Q

What is the pathophysiology of aortic stenosis?

A

Calcium deposits occur on the cusps and the cusps actually fuse, limiting the volume of blood throug

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19
Q

What are the symptoms of aortic stenosis?

A

SOB, chest pain and dizziness

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20
Q

What kind of murmur occurs in aortic stenosis?

A

Ejection systolic murmur that can radiate to the carotids

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21
Q

What are the other signs of aortic stenosis?

A
  • Low volume pulse
  • Forceful displaced apex
  • Murmur
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22
Q

What is the treatment of aortic stenosis?

A

Valve replacement, either:

  • Conventional valve replacement
  • Trans catheter aortic valve replacement (TAVI)
  • Balloon Aortic valvotomy (BAV)
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23
Q

What is rheumatic heart disease?

A

Immune reaction following infection of streptococci

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24
Q

Abnormalities of which structures can cause mitral regurg?

A
  • Leaflets eg. prolapse or rheumatic
  • Chordae rupture
  • Papillary muscle rupture
  • Annular dilation
25
Q

What are the symptoms of mitral regurg?

A
  • Breathlessness
  • Peripheral oedema
  • Fatigue
26
Q

What are the signs of mitral regurg?

A
  • Displaced apex

* Pansystolic murmur in mitral area radiating to the axilla

27
Q

What is the treatment for mitral regurgitation?

A
  • Primarily treat the HF that occurs with medicine

- Surgical: repair prolapse or replace

28
Q

What is the main cause of mitral stenosis and what is the underlying pathophysiology?

A

Mitral stenosis - cusps become almost completely fused

29
Q

What are the symptoms of mitral stenosis?

A

• Breathlessness
• Fatigue
• Palpitations (AF)
(As the left atria has to work harder to force blood through the narrowed valve, it hypertrophies which makes it more likely to fibrillate)

30
Q

What are the signs of mitral stenosis?

A
  • Malar flush
  • Tapping apex beat
  • Mid diastolic rumbling diastolic murmur localised to apex (mitral area)
31
Q

What is the treatment for mitral stenosis?

A
  • Medication: Diuretics and treat AF
  • Surgery: Valve replacement
  • Balloon Valvuloplasty: Essentially uses a catheter to crack the valve open
32
Q

What kind of problem is aortic regurg fundamentally?

A

Volume overload problem as opposed to pressure overload

33
Q

What are the causes of aortic regurg in terms of the structures affected?

A
Leaflets:
- Endocarditis
- Connective tissue disease
- Rheumatic
Annulus:
- Marfans
- Aortic dissection
34
Q

Marfans

A

Genetic disorder of connective tissue associated with long arms, high arched pallate, ocular problems and spontaneous pneumothorax

35
Q

What are the signs of aortic regurg?

A
  • Collapsing pulse
  • Displaced apex (due to a volume problem)
  • Early diastolic murmur left sternal edge in the tricuspid area
36
Q

What is the treatment for aortic regurg?

A
  • Medication: ACE inhibitors

- Surgery: Symptoms and LV dilatation or Valve replacement

37
Q

Which valvular condition will cause a murmur in the aortic area?

A

Aortic stenosis

38
Q

Which valvular conditions will cause a murmur in the mitral area?

A

Mitral regurg and mitral stenosis

39
Q

Which valvular condition will cause a murmur in the tricuspid area?

A

Aortic regurg

40
Q

True or False: Blood is normally sterile

A

True, bacteria in the blood stream is bacteraemia

41
Q

What are predisposing factors to endocarditis?

A
  • Heart valve abnormality eg. calcification/sclerosis in elderly, congenital heart disease or post rheumatic fever
  • Prosthetic heart valve
  • Intravenous drug users
  • Intravascular lines
42
Q

What is the pathogenesis of endocarditis?

A
  1. Heart valve damaged
  2. Turbulent blood flow over roughened endothelium
  3. Platelets / fibrin deposited
  4. Bacteraemia (may be very transient) e.g. from dental treatment or central line - Organisms settle in fibrin/platelet thrombi becoming a microbial vegetation
  5. Infected vegetations are friable and break off, becoming lodged in the next capillary bed they encounter causing abscesses or haemorrhage - may be fatal
43
Q

Which side of the heart is most commonly affected in endocarditis?

A

Left

44
Q

Which organisms most commonly cause endocarditis?

A
Viridians streptococci
Staph aureus
Enterococci
Staph epidermidis
Plus atypical eg. coxiella
45
Q

Which is the presentation of acute endocarditis?

A

Overwhelming sepsis and cardiac failure

46
Q

Which is the presentation of chronic endocarditis?

A
Symptoms:
• Fever
• malaise
• Weight loss
• Tiredness
• Breathlessness
Signs:
• New or changing heart murmur
• finger clubbing
• splinter haemorrhages
• splenomegaly
• Janeway's lesions/osler's nodes and roth spots
47
Q

How is endocarditis diagnosed?

A

1) 3 sets of blood cultures
2) If negative, serology for atypical organisms
3) Echo

48
Q

Which side of the heart is most commonly affected by IVDU?

A

Right (tricuspid valve)

49
Q

What is the most common organisms associated with early-presenting prosthetic valve endocarditis?

A

Staph aureus or epodermidis - Valve infected at the time of insertion

50
Q

Which organism is most associated with endocarditis with IVDUs?

A

Staph aureus

51
Q

Which antibiotics are used for native valve endocarditis?

A

Amoxicillin & gentamicin IV

52
Q

Which antibiotics are used for prosthetic valve endocarditis?

A

Vancomycin & gentamicin IV & rifampicin PO

But usually valve replacement is required

53
Q

Which antibiotics are used for drug user endocarditis?

A

Flucloxacillin IV

54
Q

Which antibiotics are used for endocarditis caused by viridian’s strep?

A

Benzylpenicillin & gentamicin IV

55
Q

Which antibiotics are used for endocarditis caused by staph epidermidis?

A

Vancomycin & gentamicin IV & rifampicin P

56
Q

Myocarditis

A

Inflammation of cardiac muscle

57
Q

What is the presentation of myocarditis?

A

Symptoms: fever, chest pain, shortness of breath, palpitations
Signs: arrythmia, cardiac failure

58
Q

How is myocarditis diagnosed?

A
  • viral PCR
  • Throat swab and stool for enteroviruses
  • Throat swab for influenza
59
Q

Which side are you more likely to notice an innocent murmur in?

A

Right, because if you were going to hear it you’d hear it in an area of low pressure