Vaccines Flashcards
Immediate protection, works for agents that are POOR immunogens or where there are no vaccinations. Can cause allergic reactions, short lived protection, transfer of disease and delays ability to vaccinate.
Passive prophylaxis
Strong protection, longer protection. Delayed response. Give when unexposed susceptible neonates, routine immunization and booster vaccines.
Active Prohphylaxis
Why is it more difficult to develop vaccines for fungal and Protozoal infections?
Because they have many more complex surface antigens.
Where are the majority of immunoglobulins passed through from mother to neonate?
Breast milk aka Colostrum
72-98%
Antibodies get from milk.
IgA, IgM, IgG : Lost in this order
How long are pups protected for from maternal antibodies?
9-14 weeks:
CDV- 9-12
CPV- 10-14
ICH/CAV- 9-12
How long do maternal antibodies protect kittens?
6-14 weeks
Administration of an antigenic product.
Vaccination
Indicates a successful induction of an immune response.
Immunization
Non-infectious/ killed vaccine that contains a immunogenicity component of an infectious agent.
Purified subunit
In vitro production of large quantities of immunogenicity proteins through genetic engineering specific antigens into bacteria, yeast or cell lines
Genetically engineered subunit protein vaccine
Added to non-infectious biologicals to increase immunostimulation and duration of immunity.
Adjuvants
3 ways adjuvants work
- Prolong antigen exposure
- Enhance antigen protection
- Increase cytokines and immune response.
Most common transdermal vaccine for dogs.
Canine Melanoma Vaccine
Alternative route that gives good local immunity, and strong IgA response. Used in canine and feline respiratory infection and FeCoV.
Mucosal Application
