Vaccinations

Question 1

What is the highest risk time for pregnant women in terms of influenza?

Answer 1

Third trimester More vulnerable to serious illness or death at this time

Question 2

Influenza vaccination provides protection for the newborn baby for up to how long?

Answer 2

Six months Data showing this is from second/ third trimester vaccination

Question 3

When should pregnant women receive the influenza vaccination?

Answer 3

As early as possible in the flu season (May-October) regardless of gestation

Question 4

How does the influenza vaccination provide protection to the newborn?

Answer 4

Passive immunity through direct transplacental transfer of maternal antibodies

Question 5

What type of vaccine is the influenza vaccine?

Answer 5

Inactivated vaccine

Question 6

For the influenza vaccinaton, what is the NNT to prevent one mum/baby from having the flu?

Answer 6

NNT = 5

Question 7

What are the contraindications to the influenza vaccine?

Answer 7

Anaphylaxis following a previous dose of any influenza vaccine Anaphylaxis following any vaccine component

Question 8

What is the optimal time for pertussis vaccination in pregnancy?

Answer 8

20-32/40

Question 9

From what gestation does active transport of maternal antibodies to the fetus occur?

Answer 9

30/40

Question 10

Pertussis antibody levels peak approximately ____ after vaccination, and wane over time

Answer 10

2 weeks

Question 11

What are two live vaccinations that women should ideally have pre-pregnancy?

Answer 11

Rubella VZV As both are live vaccines, women should be advised NOT to conceive for 28 days after having these vaccinations. These vaccinations should NOT be administered in pregnancy

Question 12

How long should conception be avoided after administration of a live vaccine?

Give two examples of live vaccines.

Answer 12

Conception should be avoided for 28 days after administration of a live vaccine.

Live vaccine examples:

• MMR for rubella
• VZV vaccine for chicken pox

Question 13

What vaccinations should be completed PRE-pregnancy?

Answer 13

• Hepatitis B
• HPV
• MMR
• VZV

Question 14

Influenza in pregnancy:

Influenza vaccination is recommended in pregnancy.

What are the:

• Maternal effects
• Fetal/neonatal effects

of influenza in pregnancy?

Answer 14

• Maternal effects:
  
  • Severe maternal illness / acute respiratory disease
  • Increased maternal mortality
• Fetal/neonatal effects (associated with severe maternal illness):
  
  • Miscarriage
  • Stillbirth
  • Preterm birth
  • Low BW
  • IUGR