VA

Question 1

Basic principles governing animal research in VA are found in the US Governments Principles for utilization and care of vertebrate animals used in testing, research and training

Answer 1

1. Animal experiments are undertaken only after due consideration of their relevance for human or animal health and the advancement of biological knowledge
2. The fewest number of animals needed to achieve scientific objectives to be used
3. The least sentient species that will permit the attainment of research objectives is to be used
4. The least painful or distressful procedures needed to meet research objectives are to be used, and all reasonable measures to minimize pain and distress should be utilized.
5. When planning an conducting studies, the principles of the 3rs need to be considered.
6. Procedure that would be considered painful in human need to be considered to be painful in animals.
7. The best possible living conditions need to be maintained for animals kept for research, training or testing purposes.

Question 2

ACORP

Answer 2

Animal Component of Research Protocol

The official VA animal protocol form used by the IACUC

Question 3

CEO

Answer 3

Appoints members of the IACuC in writing

Question 4

CRADO

Answer 4

Chief research and development officer- office research admin given the authority and responsibility for managing all human, animal and laboratory VA research activities

Question 5

CVMO

Answer 5

Chief veterinary medical officer- primary responsibility for formulating VA animal research policy
Veterinary medical and lab animal concerns are purview of the CVMO

Question 6

OLAW

Answer 6

PHS office responsible for administering PHS policy on Humane Care and Use of Laboratory Animals

Question 7

ORO

Answer 7

Primary VHa office in advising the under secretary for health on all matters of compliance and assurance regarding human subjects’ protections, animal welfare, research safety and research misconduct

Question 8

PHS Assurance

Answer 8

Documentation submitted to OLAW (USDA) by an institution that pledges that the institution will comply with PHS policy

Question 9

R&D committee

Answer 9

Charged with overseeing and approving all research projects at the medical facility.

The iacuc, subcommittee for research safety (SRS), and the institutional review board (IRB) are subcommittees of the R&D

Question 10

SRS

Answer 10

Subcommittee for research safety - reviews and approves the use of hazardous substances in VA research

Question 11

VMU

Answer 11

Veterinary medical unit - animal research facility plus the husbandry and veterinary technical personnel l assigned to care for the animals

Question 12

If serious concerns about the health and welfare of animals exists…

Answer 12

CRADO and CVMO may suspend animal research activities

Question 13

VA facilities conducting animal research must comply with…

Answer 13

Health Research Extension Act and PHS policy

Question 14

PHS Policy includes

Answer 14

US government principles for utilization and care of vertebrate animals used in testing

Guide

AVMA guidelines

Question 15

VA animal research must be covered by

Answer 15

PHS Assurance

Question 16

Who may suspend all or a portion of animal research activities if serious concerns about the health and welfare of animals used in research

Answer 16

CRADO chief research and development officer

Question 17

If significant welfare concerns are noted in the ACORP the CRADO can…

Answer 17

1. Suspend local conduct of animal research component of that application “veterinary hold” until concerns are addressed or
2. Withhold funding until VA central office concerns about ACORP are addressed to the CVMO’s satisfaction.
3. The under secretary for health or the office of research oversight also has the authority to suspend or terminate research involving animals

Question 18

Each medical facility director must serve as the

Answer 18

IO

Question 19

VMO

Answer 19

Veterinary medical officer

Question 20

VMC

Answer 20

Veterinary Medical Consultant

Question 21

Visits to a VA medical facility with ongoing program of animal research must be made by a veterinarian no less than

Answer 21

Monthly

Question 22

If VMO, VMC, clinical vet, IACUC Chair, IACUC member or any other VA employee has not been able to solve a local problem regarding ethical treatment and use of animals by working through local chain of command, the employee may contact

Answer 22

CVMO