UWORLD + Step 2 Flashcards
What is the best predictor of survival for STEMI?
Left ventricular EF
What is the treatment for STEMI?
MONA + H
Morphine
Oxygen
Nitrogen
Aspirin
Heparin
What is an ST-Elevation Myocardial Infarction (STEMI)?
ST-segment elevations and cardiac enzyme rlease secondary to prolonged cardiac ischemia and necrosis
What is the treatment for NSTEMI?
ABNHS
Aspirin
Beta-blocker
Nitrates
Heparin
Statin
What is an NSTEMI?
Indicates myocardial necrosis marked by elevation in tropinin I and CK-MB without ST-segment elevations seen on ECG
What is unstable angina?
The onset of new chest pain, accelerating or occurs at rest
Signals presence of possible impending infarction based on plaque instability
What are treatments for Angina Pectoris?
ASA
Oxygen
IV Nitroglycerin
IV Morphine
IV Beta-blocker
Can also use:
- CCBs (Diltazem, verapamil)
- ACEIs
What medications are shown to have a mortality benefits in the treatment of angina?
ASA and B-blockers
Classic Triad of Angina Pectoris?
- Substernal chest pain
- precipitated by stress or exertion
- relieved by rest or nitrates
What is Prinzmetal’s (Variant) Angina?
Vasospasm of coronary artery which resembels agina pectoris
What is Angina Pectoris?
Substernal chest pain secondary to myocardial isschemia
What are the risk factors for CAD?
Age (males >45; females >55)
Male Gender
Increased LDL
Decreased HDL
Diabetes M.
Hypertension
Family Hx
Smoking
Peripheral arterial disease
A woman with hypertension and prior MI has an examination notable for displaced PMI, an S3, a nonelevated JVP, and bibasilar rales.
What is the next best step in diagnosis?
Dilated cardiomyopathy
An echocardiogram would be the next best diagnostic step
What is the side effect of Osmotic agents (diuretics)?
- Pulmonary Edema
- Dehydration
- Contraindicated in anuria and CHF
What is the mechanism of action for Osmotic Agents (diuretics)?
- Creates increased tubular fluid osmolarity
- leading to increased urine flow
What are the sides effects of Carbonic Anhydrase Inhibitors?
- Hypercholemic metabolic acidosis
- Neuropathy
- Ammonium Toxicity
- Sulfa allergy
What is an example of an Osmotic agent?
Mannitol
What are examples of Carbonic Anhydrase Inhibitors?
Acetazolamide
What is the mechanism of action for Carbonic Anhydrase Inhibitors?
NaHCO3
Diuresis decreases total body NaHCO3
What are the side effects of K+ sparring agents?
Hyperkalemia
Gynecomastia
Sexual Dysfunction
What is the mechanism of action for K+ sparring diuretics?
Spironolactone:
- aldosterone receptor antagonist
Amiloride:
- block Na+ channels
What are some examples of potassium (K+) sparring diuretics?
Spironolactone
Amiloride
Side effects of thiazide diuretics?
Hypokalemia
Metabolic Alkalosis
Hyponatremia
and
Hyper[GLUC]
Hyperglycaemia
Hyperlipidemia
HyperUricemia
Hypercalcemia
Mechanism of action for Thiazide diuretics?
Decrease NaCl reabsorption
causes decrease the diluting capacity of the nephron
decrease calcium excretion