UWorld All Qs Flashcards
Postpartum (months later), enlarged uterus, irregular vaginal bleeding, pulmonary symptoms, multiple infiltrates on cxr, dx?
Choriocarcinoma (metastatic GTD can occur after molar preg, normal preg, or SAB), dx w/ quantitative beta-hCG
Acute onset abdl pain ddx??
GI (PUD, appe, bowel obstruction/perforation), GU (kidney stone, ectopic preg, ovarian torsion, PID), vascular (bowel ischemia), MSK
Palpable breast mass on exam (irregardless of size), first step?
> 30yo = mammography (+/- US, then core prn). <30yo = US (+/- mammography, then needle aspiration for simple cyst, vs image guided bx for complex cyst aka solid mass)
Acute breast erythema, warmth, pain, and edema w/ peau d’orange (diffuse many dimpling), dx, next step
Inflammatory breast carcinoma, mammogram US and bx
Benign breast diseases (5)
Breast cyst, fibrocystic changes, fibroadenoma, fat necrosis (post-trauma/sex, firm irregular mass, ecchymosis, and skin/nipple retraction *hyperechoic mass, foamy macrophages, fat globules, excise and return to nrml routine screen)
Eclampsia, seizure, violent muscle contractions leading to what? Shoulder held in adduction and internal rotation?
Posterior shoulder dislocation, tx is closed reduction
Indications for endometrial bx (broken down into three age groups)
> 45: AUB or post-menopausal bleeding to r/o endometrial hyperplasia/cancer
<45: AUB and unopposed estrogen, obesity, anovulation (despite stripe of less than 4mm which is the cut off for postmenopausal women, a small stripe means nothing in premenopausal), failed medical mgmt, or lynch syndrome (HNPCC)
HTN in pregnancy
The first-line agents for management of essential hypertension during pregnancy are labetalol and methyldopa. Calcium channel blockers and hydralazine are acceptable alternate therapies. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers arecontraindicated in pregnancy
Immediate postpartum or during delivery, cardiogenic shock, hypoxemic respiratory failure, DIC w/ generalized purpuric rash and bleeding from line site (coagulopathy), coma/seizures, dx and tx and risk factors?
Amniotic fluid embolism, tx w/ intubation/vent support +/- transfusion, risk factors = advanced maternal age, G5 or >, placenta previa/abruption, pre-E
Loss of fetal station, diminishing contractions, and palpable fetal parts
Uterine rupture
Adverse effect of tamoxifen (SERM)
Endometrial hyperplasia and carcinoma (good for breast bad for uterus)
Causes of hyperandrogenism in pregnancy (3 masses)
Luteoma (benign), thecal luteum cyst (benign), krukenberg tumor (met from GI cancer). All have some risk of fetal infertility virilization
Neonatal thyrotoxicosis (levothyroxine or antibody)?
Antibodies cross placenta -> s/s warm, tachy, irritable, low birth weight. Dx maternal anti-TSH receptor antibodies (can cross placenta). Self-resolving w/ disappearance of maternal antibody, symptomatically tx w/ methimazole and beta blocker
Hyperandrogenism (elevated DHEA, testosterone), oligomenorrhea (irregular >32 day cycle menses), hirsutism, elevated 17-OHP, normal electrolytes, dx?
Non-classic CAH (note normal lytes d/t spectrum of 21-hydroxylase def resulting in some aldo/cortisol and elevated 17-OHP), if elevated 17-OHP = not PCOS
S/s of placental abruption?
Vaginal bleeding, distended and TENDER uterus, and fetal tracing abnormalities
Placenta previa s/s, risk factors, mgmt
Risk = multiparity, SMOKING, previous uterine sx. Look for PAINLESS antepartum vaginal bleeding, nrml tracing, avoid digital vaginal exam or intercourse
Sudden painful onset vaginal bleeding, abdl/back pain, high freq contractions, hypertonic/tender uterus, dx and risk factors
Placental abruption! Risks = maternal HTN/pre-E, abdl trauma, prior abruption, COCAINE (back pain comes from blood pooling aka retroplacental bleeding btw placenta and uterine decidua
Vaginal and/or intra-abdominal bleeding, pain, fetal distress/demise, look for no presenting fetal parts vaginally and abdominally palpable detal parts at the rupture site, dx?
Uterine rupture
Blunt abdl trauma to pregnant mother, dx? Mgmt?
Placenta abruptio (this is the 3rd card), aggressive IV fluids and left lateral decub to displace uterus off vessels (tranfuse if persistent bleeding and hypotension unresponsive to fluids)
Mgmt of intrauterine fetal demise (death >20 wks gestation before labor)
20-23 weeks = D&E or vaginal delivery
24 weeks = vaginal delivery (C-section by maternal choice if hx of prior classical C-section - thereby preventing TOLAC essentially)
Magnesium in pregnancy indications/
Prevention of eclamptic seizures and decreases risk for cerebral palsy (neuroprotection). Signs of Mg toxicity - loss of DTRs, respiratory depression (labored effort dec resp rate), cardiac dysarythmia. Monitor urine output - since MG is cleared renally
HTN during pregnancy w/ edema, joint pain, malar rash, UA w/ proteinuria and RBC casts, dx?
SLE complicated by nephritis, ddx compared to pre-E look for decreased complement levels and inc ANA titers and usual SLE symptoms eg joint pain, malar rash
Elevated AFP vs dec AFP indications
Elevated = neural tube defects, ventral wall defects (omphalocele, gastroschisis), and multiple gestation (check fundal height correlation). Decreased = aneuploidies (trisomy 18/21)
Prenatal screening: non-diag vs diag
Non-diag (screening) = cell-free, tri-screen, quad-screen
CVS (before 15wks), amniocentesis (after 15wks); note give Rho-gam for RH-
Second tri quad screening: msAFP, inhibin A, estriol, beta hCG, levels and dx?
Trisomy 21: low AFP. elevated b-hCG, low estriol, high inhibin
Neural tube: just high AFP
Trisomy 18: just low inhibin
Small body size, microcephaly, digital hypoplasia, midfacial hypoplasia, hirsutism, clef palate, what fetal tetratogen?
Hydantoin syndrome w/ PHENYTOIN
Risk factor for clear cell adenocarcinoma of the vagina and cervix (look for hooded cervix, T-shaped uterus, small uterine cavity, vaginal septae, vaginal adenosis - structural anomalies)? Cryptochidism, microphallus, hypospadias, testicular hypoplasia in men
Dx = DES exposure (carcinogenic and teratogenic effects)
Tamoxifen (SERM) has activity where?
Blocks estrogen in breast thereby dec breast CA, also dec estrogen at hypothalamus causing hot flashes (note also inc risk of endometrial hyperplasia/CA)
Persistent eczematous ulcerating rash localized to NIPPLE w/ spread to possible vesicles, scales, bloody discharge, nipple retraction. Dz? Associated w/?
Paget’s disease, 85% a/w adenocarcinoma
Pregnancy and respiratory status/changes?
Elevated progesterone during pregnancy stimulates respiratory centers in brain to cause inc tidal vol, inc minute vent, increased PaO2 and physiological chronic compensated resp alkalosis (compare to hyperemesis card)
Hyperemesis gravidarum vs normal respiratory physiologic pregnancy changes
In hyperemesis look for alkalosis, elevated bicarb and elevated CO2. Vs normal physiologic changes: during preg expect inc tidal vol, minute ventilation -> expect to see dec in CO2 w/ alkalosis and normal bicarb
2nd/3rd trimester, elevated bile acids, elevated liver aminotransferases, elevated bili, intense puritus, dx?
Intrahepatic cholestasis of pregnancy (you missed this since you saw elevated aminotransferases - but this is possible, just r/o acute hepatitis). Tx w/ ursodeoxycholic acid
Pregnant, malaise, RUQ pain, N/V, sequelae of liver failure, look for hypoglycemia, transamnitis, elevated bili, possible DIC, NO puritus, dx?
AFLP - no pruritus and this occurs in 3rd trimester
Arrest of labor versus protraction and mgmt?
Protraction = cervical change slower than expected and inadequate contractions -> start with Oxytocin. Arrest = no change for > 4 hrs w/ adequate contractions OR > 6 hrs w/ inadequate contractions. GO to section with arrest
Postpartum hemorrhage requiring oxytocin infusion, hyponatremia, hypotension, tachysystole, p/w tonoic-clonic seizure, dx/mgmt?
Oxytocin toxicity (essentially similar to ADH, thereby causing hyponatremia -> progressing to sz), give hypertonic saline
False labor vs true?
False = mild, irregular contractions that ultimately resolve w/ no cervical change. True = regular contractions w/ inc freq and intensity (no need for GBS proph if not in true labor)
PPROM mgmt in <34 vs 34-37 wks
34: infection or fetal compromise? No = abx, corticosteroids, surveillance. Yes = abx, steroids, Mg for neuroprotection against CP, and DELIVER
34-37: abx, steroids, deliver!
Another card on fetal growth restriction (pathway for FGR)
Determine symmetric (mainly 1st tri) vs assymetric (2nd/3rd tri). Symmetric = think baby's problem (chr abnormalities and congenital infection). Asymmetric = think 1) placental (HTN and pre-gestational diabetes, NOT GDM) and 2) maternal malnutrition *shunt blood to vital organs like brain. 1st tri symmetric baby's fault; 2nd/3rd tri asymmetric baby was good, until mother/placental problem shunted blood to vital brain
IUGR ddx?
Maternal diseases (HTN, malnutrition), fetal diseases (chr abnormalities, congenital infection), utero-placental insufficiency. Remember symmetric (1st tri) vs asymmetric (2nd/3rd). Mgmt w/ weekly BPP, serial umbilical artery Doppler, serial growth US
Complications of late-term (41wks) or post-term (>42wks) pregnancies
Fetal: (bad placenta w/ large and dry baby) oligohydramnios, meconium aspiration, stillbirth, macrosomia, convulsions. Oligo = single deepest vertical pocket <2cm, OR AFI <5cm -> path, aging placenta has dec fetal perfusion -> dec renal perfusion
-> dec urinary output from fetus
Maternal complications of late/posterm: C-section, infection, PP hemorrhage, perineal trauma
Lochia types RSA - rubra red/brown, serosa thin/pink, alba white/yellow. Normal decidua shedding
Other post-partum stuff to look out for: fever >38 or 100.4 after 24hrs delivery - could be endometritis if fever or infection - abx. Also bladder fxn: nrml to have difficult initiating, as long as voiding occurs then no need for urethral catherterization, should self-resolve. D/t regional anesthesia, nerve palsy, PERI-URETHRAL SWELLING, epidural
How to suppress lactation in pt who does not want BF or shouldn’t
Breast engorgement occurs when not BF - advise to wear supportive bra, AVOID nipple stimulation/manipulation aka no dumping, use ice packs/analgesics
Random note about prolactin and GnRH
High prolactin inhibits release of GnRH from hypothalamus (that’s why BF women can be amenorrheic and menopausal like states - low estrogen)
Inability to lactate, amenorrhea, and hypotension post-partum, dx?
Sheehan syndrome - absent LH/FSH/prolactin d/t pituitary infarction
Post-partum exclusive BF, w/ 12 wks amenorrhea, dx?
Elevated prolactin inhibits GnRH thereby inhibiting LH/FSH causing anovulation and menopausal like states (low estrogen)
Post-partum fever unresponsive to abx, dx and mgmt?
Because the most common etiology for puerperal fever is endometritis, patients are initially treated empirically with antibiotics. Persistent fever unresponsive to broad-spectrum antibiotic therapy and a negative infectious evaluation (eg, blood and urine cultures, urinalysis) suggest septic pelvic thromboplebitis, which is a diagnosis of exclusion. Risk factors include cesarean delivery and chorioamnionitis/endometritis. Treatment is with anticoagulation and broad-spectrum antibiotics
Note on physiologic vaginal discharge
Cervical mucus just prior to ovulation is profuse, clear, thin, and corresponds w/ LH surge, not a finding of infection
VS cervical mucus plug = barrier to ascending infection during preg
*brown, red, or yellowish thick mucus that is shed before or during labor
Whats in primary ovarian insufficiency?
Oligomenorrhea/amenorrhea, infertility and menopausal symptoms (hot flashes), ELEVATED FSH, and dec estradiol level. VS ugh you missed hypogonadotropic hypogonadism (low FSH and low estradiol, d/t low weight -> low GnRH -> LOW FSH/LH/estradiol). So elevated FSH = primary ovarian insufficiency; low FSH = hypogonadotropic hypogonadism
Unilateral abdl pain in young women with menses just 14 days ago (not long enough for preg…), pain occurring middle of menstrual cycle, dx?
Mittelschmerz = physiologic cause of unilateral pain corresponding with ovulation, reassurance
STI treating partners?
Just trichomoniasis (BV think bacterial flora found normally)
70yo vaginal lesion, bloody discharge, smoking, dx?
Squamous cell carcinoma, dx w/bx (APGO vaginal lesions two processes - cancer vs inflammatory)
Not vulvodynia (external pain) but what: pain w/ vaginal penetration, distress/anxiety over symptoms, no other medical cause =
Genito-pelvic pain/penetration disorder (vaginismus), risk factors include sexual trauma, lack of sexual knowledge, abuse, tx - desensitization therapy/kegels