uworld

Question 1

typical findings in hyper IgE syndrome

Answer 1

cold abscesses, sinopulmonary infections, atopic dermatitis

Question 2

in acute transplant rejection, biopsy will show

Answer 2

lymphocytes

Question 3

seronegative spondylopathies (ankylosing spondylitis, reactive arthritis, arthritis associated with inflammatory bowel, psoriatic arthritis) have higher incidence of

Answer 3

HLA-B27

Question 4

HLA-B27 encodes

Answer 4

MHC class I

Question 5

conditions associated with HLA class II allele include

Answer 5

type 2 DM, RA, & celiac disease

Question 6

__ is a known complication of vaccine administration that typically involves a prodrome of pallor, diaphoresis, and bradycradia

Answer 6

vasovagal syncope

Question 7

paroxysmal nocturnal hemoglobinuria leads to formation of

Answer 7

membrane attack complexes on erythrocytes

Question 8

__ is the most imp immune cell in the protection against candida and is able to prevent germination of candida yeasts into penetrating hyphae

Answer 8

neutrophils

Question 9

atopic dermatitis increases the risk for

Answer 9

allergic rhinitis, asthma, and food allergies

Question 10

programmed-death receptor 1(PD-1) is a checkpoint inhibitor that downregulates what response

Answer 10

cytotoxic T cell

Question 11

the late phase of type I hypersensitivity reactions manifests as

Answer 11

indurated skin lesion hours after exposure to the allergen due to local tissue damage by major basic protein released from eosinophils

Question 12

immunosenescence is the normal age related decline that impairs most aspects of immune function including the production of

Answer 12

naive B and T cells

Question 13

transporter associated with antigen processing (TAP) proteins are necessary for loading of cytoplasmic (viral) proteins on to

Answer 13

MHC I

Question 14

atopic dermatitis is caused by what Immune response

Answer 14

Th2

Question 15

fever, vomiting, muscle pains, and erythroderma are manifestations of

Answer 15

toxic shock syndrome

Question 16

super antigens react with

Answer 16

macrophages & T lymphocytes

Question 17

calcineurin role

Answer 17

promotes IL-2 release to activate T cells

Question 18

plasma cells on biopsy

Answer 18

clock face

Question 19

presense of >10% plasma cells in bone marrow raises suspicion for

Answer 19

multiple myeloma

Question 20

__ development is particularly affects with multiple myeloma

Answer 20

B cell (so decreased immunoglobulins)

Question 21

allergic contact dermatitis is what type of reaction

Answer 21

delayed type hypersensitivity where initially langerhans cells travel to lymph nodes and present haptens to naive T cells

Question 22

hyper acute rejection is caused by

Answer 22

preformed IgG antibodies

Question 23

hyper acute rejection is what type of hypersensitivity

Answer 23

type II

Question 24

glucocorticoids inhibit

Answer 24

transcription of pro inflammatory mediators and promote apoptosis of eosinophils, T cells, & macrophages

Question 25

C3a & C5a are anaphylatoxins that cause

Answer 25

skin rash, joint arthralgia, & high fever

Question 26

Kartagener syndrome is a form of

Answer 26

ciliary dyskinesia

Question 27

primary ciliary dyskinesia can result from failure of

Answer 27

dynein arms to develop

Question 28

patients is primary ciliary dyskinesia experiences

Answer 28

recurrent resp infections, situs inverses, and infertility in males

Question 29

what is responsible for neutrophil transmigration

Answer 29

pecams

Question 30

leukocyte adhesion deficiency type 1 sxs

Answer 30

skin infections without pus & delayed detachment of umbilical cord