UW Peds 1 Flashcards
kid comes in with obviouse Guillian-barre what is an important test for you to run? why?
spirometry to assess respiration = GB pts are at high risk for respiratory failure
Erythema Toxicum Neonatorum(ETN) symptoms
asymptomatic, blotchy, erythematous papules and pustles seen in neonates = BENIGN! can change color and always spares palms and sole.dnt know cause but it will go away so just reassure parents
Chronic Granulomatous Diseaseinfections with which type of organisms? what will you see on bx?
catalase +, numerous organism filled segmented neutrophils
Kids with juvenile idiopathic arthritis obv have arthritis but also have chronic ——. Complications? Tx?
Chronic uveitis! Can go blind! Tx w/steroids
what is premature 2nd sex development in girls and bosy?
girls <8; boys <9
> 5 yo kid has nocturesis & all other treatment has failure…what do you do?
give desmopressin
Neimann-Pick Dz sx?
loss of motor milestones about 2-6m, hypotonia, feeding difficulty, cherry red macula, HEPATOSPLENOMEGLY, AREFLEXIA
bedwetting is normal before the age of….
5 = wait to treat untill then.
Tay-Sachs Dzdef? inheritance?
AR, B-hemosaminidase A
Neurofibromatosis T2sx?
NF2 mutation = bilateral acoustic neuromas
sx of HUS
microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury
Cervical Lymphadenopathy in children
mcc S.aureus = enlarged, tender, erythematous lymph nodes
Gaucher Dzsx?
anemia, thrombocytopenia, HEPATOSPLENOMEGLY, no regression just fatigue and usually appears older kids.*both this and neimann-pick have hepatosplenomeg but np appears 2-6m w/o blood shit
how can you distinguish central/hypothalamic/pituitary 1 ammenorhea vs peripheral/gonadal
check FSH!- decrease FSH = central = do MRI-increased FSH = peripheral = gonadal prob
Neimann-Pick Dz def? inheritance?
sphingomyelinase, AR
Neurofibromatosis T1(T1 von rec)mutation? sx?
NF1 gene; 1. cafe-au-lait spots2. axillary freckling3. monocular eye proptosis & visual changes = OPTIC TRACT GLIOMA4. lisch nodules5. neurofibromas
Kid has high lead on capillary finger stick. What do you do?
Draw venous lead levels bc cap can be false.
Marfans vs Homocystauriawhich one has aortic root dilation?
marfans
Gaucher Dzdef? inheritance?
AR, glucocerebrosidase
common causes of meningitis in kids >11yo
N. Men
Sturge-Weber Syndrome sx?
focal or generalized seizures, mental retardation, “Port-wine” stain, IC calcifications
Absence Seizures sx?
<20sec, utually 4-10yo, may be accompanied by simple AUTOMATISMS(eye fluttering, lip smacking)
common causes of meningitis in kids 3m-10yo
S.pneumo, N. Men
Retinoblastomamut? sx?
mut Rb; optic nerve retinoblastoma*associated with osteosarcoma
Tx of tourettes
1st line = A2 ag: Clonidine or Guanfacine2nd line = antipsychotics: Risperidone
Breast Milk Jaundice vs Breasfeeding Failure Jaundice
- breast milk jaundice: appears in week 1, seen with adequate breastfeeding, normal exam, due to increase conjugate intestinal bilirubin.2. breastfeeding failure jaundice: appears in week 1, due to decrease lactation and increase bili, seen w/suboptimal breastfeeding, sx of dehydration = tx by increaseing feeding
Long term consequence of vesicouretral reflux?
Renal scarring
Krabbe Dzdef? inheritance?
AR galactocerebrosidase
Pellagra
Niacin B3 def = diarrhea, dermatitis, dementia, glossitis
test for chronic granulomatous disease?
check for neutrophils w/dihydrorhodamine 123 tests & nitroblue Tetrazolium test
Sx of Lyme dz infection
mild pain + joint stiffness that may be on and off, flu like symptoms, fatigue, variable joint pains
Chronic Granulomatous Diseaseinheritance?
XLR
Sx of kid with Posterior Urethral Valves
potters sequence + hydroureter/nephrosis, usually seen in males
What’s neonatal acne?
Acne peaks between 2 to 4 weeks occurs due to maternal hormone transmission
what vitamin can you give that will decrease mortality in measles?
vitamin A
tx of SS dz
hydroxyurea
tx of childhood lead poisoningmoderate vs severe
- moderate(45-69): Meso-2,3-dimercaptiosuccinic acid(DMSA)- severe(>70): DMSA + Calcium disodium edetate(EDTA)
Describe Dermatatitis Herpetiformis. What its associated with?
“red spots on arms and legs filled with clear fluid that later crusts over”
GI “target sign” is associated with….
intusseption
causes of baterial rhinosinusitis
Strep. Pneumo > H. Influenza > Moraxella Cat
What’s a herald patch?Tx?
Pityriasis Rosea ! Associated w/HSV 6/7 but not sure which. Lasts 2-12 weeks tx w/topics steroids
What is adequate breastfeeding?
breastfeeding 8-12 times a day every 2-3 hrs for about 10-20 min per breast during the 1st month
Bow legs is normal till…
2y
Friedreich Ataxia sx?
ataxia, dysarthria, degradation of spinocerebellar tracts, hypertrophic cardiomyopathy, diabetes, skeletal deformities(kyphosis, scoliosis)
Friedreich Ataxiamutation? inheritance?
AR mut in fraxtin = GAA triplet
HUS causes hematuria by….
vascular dmg causing microthrombi = mechanical dmg
Henoch-Scholein Purpura sx
low grade fever, cough, nonblanching rash on butt and legs, arthralgias, abdominal pain, intussecption, kidney shit
Kawasaki Disease diagnosis criteriawhat are they at increased risk for?
fever >5d +4 or more:1. conjunctivitis2. mucositis(strawberry tongue)3. cervical lymphadenopathy4. rash5. erythema & edema of the hands and feet*increased riks of coronary artery aneuryms
Marfans vs Homocystauriawhich one has mental retardation?
homocystauria
Marfans vs Homocystauriawhich one has fair complection?
homocystauria
Scarlet Fever sx + tx?
*seen w/untreated strep shitfever, chills, sore throat, strawberry tongue, rash(sunburn w/goosebumps or sandpaper or rough texture)
common causes of meningitis in kids <3m
GBS, Ecoli, Listeria, HSV
Kid with toothache has been using numbing cream to treat. now presents w/cyanosis, pulse ox 85%. dx? why? tx?
methemoglobinemia, caused by oxidizing agents = dapson, nitrates, topical anesthetics(benzocaine & lidocaine)*will see normal PaO2, saturation gap, normal arterial partial pressuretx: methylene blue
McCune-Albright Syndrome
de novo mut in G-protein cAMP(GNAS)Triad: precocious puberty, cafe-au-lait spots, fibrous dysplasia of bones + HYPERENDOCRINE due to increased cAMP activity = elevated cortisol = cushing symptoms
Riboflavin B2 deficiency
Chelioliss, Glossitis, seborrhetic dermatitis, pharyngitis,
Fanconi anemiasx?
XLR aplastic anemia with progressive bone marrow failure, short stature, hypergonadism, hypo pigmentation, low set ears, deafness, abnormal thumbs, microcephaly, cafe au lair spots
Tay-Sachs Dzsx?
loss of motor milestones around 2-6m, hypotonia, feeding difficulties, cherry red macula, HYPERFLEXIA
MCC of sepsis in SS dzWhat can you do for them?
S. Pneumo = pplx with PCN till the age of 5
Pertussus ppx for baby
erythromycin
RDW in iron deficiency vs thalassemia
RDW is increased in iron but normal in thalassemia
what is the most common congenital heart defect in kids with DS?
complete AV septal defect
RF for RDS in newborns?
Prematurity, male sex, perinatal asphyxia, maternal DM, C-section w/o labor
what effect doesn PROM have on RDS?
decreases RDS due to increase stress = cort = help lungs mature
Trendelenburg Gait
hip drop due to dmg to superior gluteal N = weak gluteus muscles
CF infertility in men. why?
congential absence of vas def
Premature baby give vaccinations according to —– age. What the exception?
chronological; exc: HepB! baby must be >2kg for this vaccination
Trachoma
chlamydia infection in the eye that can spread in unsanitary condition like a refugee camp.1. conjunctival injection2. tarsal inflammation(eye lid)3. pale follicles(bumps under eye lid)4. often seen w/rhinorhea, pharyngitistx: azithromycin
Which nephrotic syndrome is most associated with…1. HBV?2. HIV?3. A1AT?
- HBV = membranous2. HIV = FSGS3. A1AT = membranoproliferative
SS trait causes spontaneously resolving hematuria due to….
microthrombi causing renal papillary necrosis
Werdnig Hoffman dz vs Botulism
WH: anterior horn degen; upper ext > lower, lacks eye shitBot: hx of ingestion; Ptosis, sluggish pupillary light reflexBOT SPORES: no hx of ingestion, kid will be breast fed; Ptosis, sluggish pupillary light reflex