UW Flashcards
How to Dx asthma?
Px & Hx
Spirometry ( FEV1 & PEF).
If spirometry is normal = methacholine challenge test.
How to interpret methacholine challenge test?
It’s a muscrinic cholinergic agonist.
Causes bronchoconstruction and increased airway secretions.
I.e FEV1 by >20%.
What’s scopolamine?
What is it used for?
Muscarinic receptor antagonist.
Used for motion sickness.
What’s phenoxybenzamine?
What does it treat?
It’s a non-selective a-adrenergic antagonist.
Used in pheochromocytoma.
What’s asthma?
Obstructive airway disease.
Hypersensitivity of conducting airways to stimuli.
Karyotype of turner’s?
45 XO
Clinical features of turners?
Menarche?
Labs?
Short stature Thickened neck Square chest Widely spaced nipples. No breasts. Normal sexual hair distribution. No menarche.
High LH & FSH.
Can turner’s become pregnant?
They have ovarian failure, can’t.
Can use IVF with donor oocyte.
Need supplementation with estrogen & progesterone to maintain uterine lining.
What risk pregnancy has on turner’s women?
- What’s your action?
Aortic dissection or rupture.
Must evaluate cardiac & renal function throughout pregnancy.
What are the signs of DKA?
Mental status changes Dehydration Abdominal pain Tachypnea Fruity odor of breath.
+
Metabolic acidosis & high AG.
What are the finding of DKA on ABG?
Metabolic acidosis
With high anion gap.
PH
Treatment of DKA?
How does it work?
Insulin & hydration with NS.
• Insulin:
Utilization of glucose > lipolysis > normalizes glucose & stop Keton bodies = increased HCO3.
Intercellular shift of K = K in blood.
• NS:
Normalizes Na in blood & decreases osmolality.
Describe ABG changes is hypoaldosternism (RTA IV)
Metabolic acidosis with normal AG.
Treatment of metabolic acidosis in hypoaldosternism?
How does it work on ions, acids & osmolality?
Exogenous mineralocorticosteroids.
- Na/H2O retention.
- H & K excretion > hypokalemia & ⬆️HCO3.
- Increases serum osmolality.
How does loop diuretics affect ions, acids & osmolality?
• Decrease Na/H2O retention:
Low Na, low fluids > high serum osmolality.
- Loss of K = Hypokalemia.
- Retains HCO3.
What causes fruity smell of breath and urine in DKA?
Excretion of acetone
What 2 acids accumulate in DKA?
B-hydroxyburate
Acetoacetate
What’s minute ventilation?
How is it calculated?
It’s the volume of air that enters the respiratory pathways per minute.
Minute Volume = tidal volume x RR
What’s alveolar ventilation?
How is it calculated?
Volume of air reaching alveoli per minute i.e doesn’t include dead space.
Alveolar ventilation = (Tidal volume - dead space) x RR
What’s physiologic dead space?
How is it calculated?
Anatomical (conducting airways) and alveolar (well ventilated but poorly refused alveoli) dead space.
Physiological dead space = tidal volume x ([PaCO2 - PeCO2] / PaCO2)
During what stage of cardiac cycle does most of blood supply to myocardium occur?
What’s the major factor affecting myocardial blood flow?
Why?
80% of blood supply is during diastole
And depends mostly on duration of diastole.
Why?
Systole => the open aortic valve partially blocks coronary flow and coronary arteries are compressed by the contracting myocardium.
What happens to cardiac supply during exercise?
⬆️ HR and ⬇️ diastole
> more demand and less time to provide oxygen.
Adenosine (from ATP) vasodilates coronary vessels and increases blood flow.
What’s the type of inheritance in CF?
Autosomal recessive
Where’s the defect in CF?
Cystic fibrosis transmembrane conductance regulator (CFTR) gene on chromosome 7.
F508 mutation.
What’s the F508 mutation?
What does it cause?
Deletion of 3 nucleotides coding for phenylalanine at position 508 of the CFTR protein.
Causes CF.
What’s the CFTR transmembrane protein and what does it pump?
How is it related to mucosal surfaces?
An ATP-binding cassette transmembrane ion transporter.
Pumps Cl out of epithelial cells against its concentration using ATP hydrolysis for energy.
By pumping Cl it creates a membrane potential that draws Na and H2O which hydrates mucosal surfaces like bowels and airways.
What’s the role of CFTR protein in sweat formation?
It plays a role in forming a hypotonic sweat.
Sweat is initially isotonic with the plasma, during transport through the ducts Na is removed from the ductal lumen by CFTR.
What’s the effect of CFTR defect on sweat in CF patients?
CF patients have high Cl in sweat
What test is used to screen for CF?
Sweat Cl Test.
Where are voltage-gated channels commonly found?
In neurons.
What’s the function of LH in males?
Stimulates the release of testosterone from the lyeding cells.
Where is LH released from?
Gonadotroph cells in the anterior pituitary.
What’s the function of FSH in males?
Release of inhibin B from the Sertoli cells in seminefrous tubules.
What’s the karyotype of Turners Syndrome?
45, XO (loss of paternal Ch X)
Classic Characteristics of newborn with turner’s syndrome?
- Cystic Hygroma = posterior neck mass of cystic spaces.
- Lymphedema = Bilateral extremities swelling.
- Coarctation of aorta = diminished femoral pulses.
What’s the pathology in congenital adrenal hyperplasia?
What’s the most common enzymatic defect?
Abnormal sexual differentiation due to defective hormone synthesis.
Most common enzymatic defect = 21-OH deficiency.
How do newborn with congenital adrenal hyperplasia present?
Girls have ambiguous genitalia and salt wasting (hypotension & low Na)
What’s the cause of pathology in androgen insensitivity syndrome?
Defective testosterone receptors.
What is the karyotype in androgen insensitivity syndrome?
46, XY
How do patients with androgen insensitivity syndrome present? (Phenotype)
Adolescent 46,XY how appears phenotypic ally female, has primary amenorrhea.
Presence of cryptorchid testes.
What’s the cause of primary amenorrhea in androgen insensitivity syndrome?
Absence of internal female reproductive tract.
What’s the cause of pathology in Trisomy 18 (Edward Syndrome)?
Meitotic nondisjunction.
Mention some of the symptoms of Trisomy 18?
Cardiac defects. Clenched fists. Rocker bottom feet. Omphalocele. Low set ears.
What’s the cause of pathology in Cri-du-chat?
Deletion of the short arm of Ch 5 (p5-)
What is the cause of pathology in Trisomy 21?
Meiotic nondisjunction
Robertsonian translocation.
What’s the mode of inheritance in Fragile X?
X-linked.