USMLE World 2x misses

Question 1

Vitamin D deficient rickets shows what in the bone

Answer 1

Osteoid matrix accumulation around trabeculae

Question 2

order of enzymes in base exision repain

Answer 2

glycosylase, Endonucleoase, lyase, DNA polymerase, ligase

Question 3

auer rods indicate

Answer 3

AML

Question 4

antibiotics for beta lactamase producing gram - rods

Answer 4

piperacillin-tazobactam

Question 5

enzyme that allows bacteria to incorprate RNA primers into their DNA during replication

Answer 5

primase

Question 6

deficient enzyme in porphyria cutenea tardea

Answer 6

uroporphyrin decarboxylase

Question 7

sun blistering porphyria

Answer 7

cutenea tardea

Question 8

antiviral reverse transcripterase/DNA polymerase inhibitor that does NOT require intracellular activation by viral/cellular kinases (works in vitro)

Answer 8

foscarnet

Question 9

collegen defect with soft and loose skin with mutile acchymoses on limbs, and hypermobile joints

Answer 9

ehlers danos

Question 10

collegen sensitive step impaired in ehlers Danlos

Answer 10

extracellular cleavage

Question 11

endogenous substances that can lead to insuline resistance by abberent serine and theonine phosphorylation by serine kinase

Answer 11

TNF-a, catecholamines, glucocorticoids and glucagon

Question 12

Side effects of ACEi

Answer 12

decreased GFR, hyperkalemia, cough

Question 13

BP med that can cause angioedema

Answer 13

ACE inhibitor

Question 14

carries nerves and vessels to ovaries

Answer 14

suspensory ligament

Question 15

crystals that cause gout

Answer 15

monosodium urate

Question 16

Tx for diptheria infection

Answer 16

passive immunization (diptheria antitoxin), is the most important thing to do

Question 17

kid with blast cells in blood, with mediastinal mass

Answer 17

most likely T-Cell ALL (B cell is more common ALL, but does not make mass

Question 18

anticoagulanr that can rarely cause neutropenia in long term

Answer 18

ticlopadine

Question 19

ceremide trihexoside accumulation leads to

Answer 19

Fabry dx (causes renal failure). deficiency of alpha-galactosidase A

Question 20

most important tx in acute diptheria infection

Answer 20

antitoxin (passive immunity)

Question 21

nonradiolucent kidney stones is probably made up of

Answer 21

uric acid

Question 22

tazobactam increases the efficacy of amoxicillin by…

Answer 22

decreasing beta-lactamase production by the bug, increasing avaiability of beta-lactam drug itself

Question 23

breaks down blood in a bruise, and turns it green

Answer 23

heme oxygenase

Question 24

CD markers in B-ALL

Answer 24

TdT+. CD10+, CD19+ (T-cell would all be less than 10)

Question 25

ehlers danos presents as

Answer 25

hypermobile jonts, easy bruising, hyperelastic skin

Question 26

collegen processing defect in ehlers danos

Answer 26

extracellular cleavage (

Question 27

causes one sided nasal hemianopia

Answer 27

lesion in right peri-chaismal area (often anyrusm or calcification in internal carotid)

Question 28

kidney risk in hysterectomy

Answer 28

uterer can be accidently ligated along with the uterine artery

Question 29

anti cholesteral med that can raise TGs

Answer 29

cholestyramine

Question 30

secretes hydrogen from intercalated cells of the collecting tubules

Answer 30

aldosterone

Question 31

effect of aldosterone on the nephton

Answer 31

causes reabsorption of sodium and water and loss of K+ and H+

Question 32

homologous chromosomes seperate in what phase of meosis

Answer 32

mesosis I

Question 33

relationship between lumen radius loss and flow change

Answer 33

flow change is loss of lumen to the 4th (i.e. i/2 loss of lumen = 16x loss of flow)

Question 34

pioglitazone can damamge what orgon

Answer 34

liver

Question 35

combo of AZR and gangicilor can cause

Answer 35

neutropenia

Question 36

loss to followup in studies can create what bias

Answer 36

selection

Question 37

alkaptonuria (black urine dx) blocks what

Answer 37

tyrosine (from phenalyline) to fumerate (needed for TCA cycle)

Question 38

viruses that can undergo gentic reassortment when exposed to aminal orthomyxovirues

Answer 38

flu and rotovirus

Question 39

inactivates 6-mercaptopurine

Answer 39

xanthanine oxidase

Question 40

used to treat cyanide poisoning in nitrate OD

Answer 40

sodium thiosulfate

Question 41

QRS complex corresponds to what phase in ventricular AP graph

Answer 41

0 phase

Question 42

what happens in the 0 phase of ventriculat AP

Answer 42

rapid, Na mediated deporalization

Question 43

what drugs modulate the 0 phase of ventricular depolarixation

Answer 43

class I antiarrythmics (slow Na inward movememt)

Question 44

used to control acute PSVT

Answer 44

adenosine

Question 45

SE of adenosine

Answer 45

flusing, burning in chest and SOB