usmle step 1 Flashcards
67 yr. pt w/bilateral ankle edema. Large v waves, soft pansystolic murmur audible at left sternal edge. F.Aid 2019, pg 288-9)
Tricuspid regurgitation
33 yr. pt attempting suicide injected w/molecular weight heparin. pain in flanks, BP 50/30. Blood sugar 20mg/dl. Cause of death? F.Aid 2019 Pg. 334
Acute adrenal insufficiency
12 month pt. w/rash in his face. over a week ago with slight cold and frebile. complication with his illness? F. Aid 2019 pg. 164
Fetal death if a pregnant woman becomes infected
60 yr old pt. with muscle pain and dark color urine. rx erythromycin for bacterial infection. ischemic heart disease, hypercholesterolemia and taking multiple medications. Responsible for pts symptoms? F. Aid 2019 pg. 249
Rhabdomyolysis
75 yr old pt. constipated, diarrhea and weight loss over the past 3 months. appears cachectic and nodular hepatomegaly. Not jaundiced and liver function tests are normal. Diagnosis? F. Aid 2019 pg. 382, 386
Liver metastasis
43 yr pt right upper quadrant pain (ultrasound) showing dilated gall bladder and dilated biliary tree. Symptoms if she’s left untreated? F. Aid 2019 pg. 66
Difficulty seeing at night
24 yr old pt. w/intermittent pain, numbness and weakness in his left arm. Blue discoloration in his arm. What’s present with the patient? F.Aid 2019 pg. 441
Thoracic outlet syndrome
35 yr old man embalmer with acute onset respiratory distress. 3 day history of mild fever and malaise. oxygen saturation is 82% and respirations are 22/min. x rays shows interstitial opacities in both lungs. what’s the underlying pathology? F. Aid 2019 pg. 662
Chemical pneumonitis
Exposure to formaldehyde
21 yr old man with 3 day history of dysuria and swollen right knee. 3 sexual partners within the past month without protection. no rashes or overlying skin involvement. His knee culture is plated on Thayer-Martin agar which grows bacterial colonies. The culture would aspirate the following bacteria? F. Aid 2019 pg. 126, 142, 460
Gram-negative diplococci within neutrophils
7 yr old girl w/ abdominal pain, large breast for her age. Tanner stage 3 breasts and pubic hair and a palpable tender mass in the left lower quadrant. What’s the condition of the patient? F. Aid 2019 pg. 632
Thecoma
estrogen producing non-malignant ovarian mass
16 yr old boy w/itchy skin lesion. diagnosed w/cutaneous dermatophytosis and given a course of griseofulvin. Severe abdominal pain and numbness and tingling in his fingers. The enzyme induced by griseofulvin requires which cofactors? F. Aid 2019 pg. 67, 417
Vitamin B6
2 yr old boy w/abdominal pain and bloody stools. colonoscopy is unrevealing. A technetium (99m Tc) pertechnetate scan is positive in the right lower quadrant. Which following embryotic structures most likely failed to obliterate in this patient? F. Aid 2019 pg. 604
Vitelline duct
45 yr old man with coronary heart disease, hypertension, diabetes, and seizures w/decreased exercise tolerance. used to walk a mile a day. No history of anemia, denies alcohol intake and eats a normal diet. His Rx: aspirin, atorvastatin, lisinopril, metformin (began taking last yr) and phenytoin. Which rx is responsible for his presentation? F. Aid 2019 pg. 249, 412
Phenytoin
Megaloblastic anemia. Type of anemia caused by deficiency of B12, folate and medications that interfere with B12 metabolism such as phenytoin, methotrexate and sulfa drugs.
Decreases mucosal uptake of folate and interferes with folate metabolism, leading to macrocytic anemia
2 week old neonate with a 46, XY karyotype is born with ambiguous genitalia. temp is 36.9C (98.4F) BP 120/80mmHg. (>99% for his age) (high). pulse is 110 min. Potassium of 3 mEq/L. (low) Which enzyme deficiencies is most likely present?
F. Aid 2019 pg. 328
17 Hydroxylase
26 yr old man w/large macules and freckles in the axilla and groin. Learning difficulties. Family history of other affected individuals. Which is the usual mode of inheritance of this condition? F. Aid 2019 pg. 60, 513
Autosomal dominant
22 yr old man w/double vision and impaired balance. medical history fro a surgically resected medulloblastoma during childhood. Neurological exam reveals nystagmus, absent smooth pursuit, head tilting, and truncal ataxia and difficulty performing “finger to nose test” Which is the cause of pt condition? F. Aid 2019 pg. 487, 516
Medial lesion involving the flocculonodular lobe of the cerebellum
32 yr old woman w/low mood, weight gain (15lbs), irregular menses. no period for the past 3 months. on exam, she has several bruises, a rounded face, and increased growth of facial hair on her chin and upper lip. Which is the diagnosis? F. Aid 2019 pg. 333
Adrenocortical tumor
34 yr old woman w/increase fatigue over the last 6 months. Episodes of pneumonia, UTI. History of atrial fibrillation, hyperthyroidism, gout and schizophrenia. Rx: allopurinol, metroprolol, methimazole, clozapine, pantoprazole and iron. Temp (99.7), BP 124/68 mmHg. pulse is 112 min. respirations are 24 min. Which is responsible? F. Aid 2019 pg. 249, 349
Methimazole
known to cause aplastic anemia
23 yr old man w/pelvic fracture when he fell. Perineal pain and inability to void urine. Physical exam shows blood at the urethral meatus. Which is consistent with the diagnosis of a ruptured urethra? F. Aid 2019 pg. 613
Swelling over the lower abdominal wall and scrotum
42 yr old man w/3 month history of hand pain. works as a computer programmer. He wakes up in the middle of the night with discomfort and hand hanging off the bed. Numbness along his palm. Which is the most likely etiology of this patient’s symptoms? F. Aid 2019 pg. 451
Carpal tunnel syndrome
6 month old Ashkenazi boy w/developmental delay and inability to hear and see. cherry spot on the macula, progressive neurodegeneration and no hepatosplenomegaly. which deficiency is linked to the pathogenesis of this disease? F.Aid 2019 pg. 88
Hexosaminidase A
19 yr old woman agitated and believes she can fly. temp (100.5 F), BP (166/100 mmHg), pulse (130/min). pupils dilated, round and reactive to light. what’s the patient’s cause of current clinical condition? F.Aid 2019 pg. 561
Cocaine
30 yr old man w/ 2 week history of erectile dysfunction with 2 month history of decreased libido and recurrent headaches. BP (98/70), pulse (85 min), respirations 14 min. what’s elevated in this patient? F.Aid 2019 pg. 326
Prolactin
64 yr old american man w/severe low back pain. xray shows severe erosion in his spine and skull. increased levels of IgG in his blood and Bence Jones protein in his urine. Diagnosis? F.Aid 2019 pg. 423
Multiple myeloma
A randomized placebo conducted to assess the benefit of stain therapy in primary prevention of cardiovascular disease. After 1 year, the cardiovascular event rate in the active arm is 1% and the placebo arm is 2.5%. which is the number needed to prevent one cardiovascular event over 1 yr? F.Aid pg. 258
67
0.025-0.01 =.015
1/.015=6.67
60 yr old woman w/sluggish, weight gain and constipation. brittle hair and skin. she has antibodies against thyroglobulin and thyroperoxidase. A biopsy of the thyroid gland demonstrates? F.Aid pg. 338
Hurthle cells
81 yr old woman w/throbbing headache. gets worse in the mornings, when coughing, sneezes or strains. History of 2 non-small cell lung cancer and received chemo and radiotherapy. Failure of abduction of her right eye. which treatment is indicated. F. Aid pg. 526
Radiation therapy
5 yr old boy w/right hip pain. Trendelenburg’s sign when standing on the right leg. xray shows right hip swelling in soft tissue. Bone scan shows reduced activity in the anterolateral right capital femoral epiphysis. what’s the diagnosis? F.Aid pg. 453
Legg-Calve-Perthes disease
62 yr old woman fell w/fracture of the distal radius. xray shows more than 2.5 standard deviations below that of normal healthy adults. shes prescribed meds for future fractures. which drug will be prescribed?
Foscarnet
A newborn w/respiratory distress and fever. Child is Ashkenazi jewish heritage. chest xray reveal multi-lobar
pneumonia and sweet chloride test is positive. Sputum culture grows gram-positive cocci in clusters with golden-yellow pigment. which pathogen is responsible?
F.Aid pg. 179
Staphylococcus aureus
35 yr old obese woman w/hirsutism and abnormal menses that vary in duration, timing and amount of bleeding. she’s diagnosed with impaired glucose tolerance 2 years ago. lab shows luteinizing hormone is elevated. serum androstenedione and testosterone are mildly elevated. sex hormone binding is decreased. 17-hydroxyprogesterone is normal. ultrasound shows bilaterally enlarged ovaries with multiple cysts. what’s the diagnosis? F.Aid pg. 631
Polycystic ovarian syndrome
83 yr old woman w/increased difficulty breathing. pain in left ear. serum impaction in left ear and mild otitis externa. Weber and Rinne exam is done with 512 Hz tuning fork. what are the test results? F.Aid pg. 521
Weber lateralizes left, BC>AC left