Urology Flashcards
What GFR indicates kidney failure
< 15
What is the number 1 cause of renal vascular disease
Diabetic kidney disease
What in the labs, indicates an AKI
An abrupt or rapid decline in renal filtration
Elevated serum creatinine and decrease GFR
Azotemia
What is azotemia
rise in blood urea nitrogen (BUN) concentration
What causes pre renal azotemia
perfusion (50%) – kidney working fine but the things that perfuse it aren’t
volume loss, heart failure, loss of peripheral vascular resistance
What is the most common cause of prerenal azotemia
Hypovolemia
*meds: ACE, ARB, NSAID, Contrast
What causes intrinsic kidney injury
Tumor lysis syndrome
Vasculitis (SLE, Sarcoidosis)
Crystals from gout
Myoglobin from rhabdomyolysis
Nephrotoxic drugs
What are nephrotoxic drugs
aminoglycosides (gentamicin), cyclosporine
What do RBC casts indicate
glomerulonephritis
What do WBC casts indicate
Pyelonephritis
What do muddy brown casts indicate
ATN
What do waxy casts indicate
CKD
What do Hyaline casts indicate
Normal
How do you treat an AKI
IV Fluids remove drugs if present and sometimes Lasix to get the kidneys moving
What is generally the cause of post renal AKI
Obstructive issue –> most likely the prostate
What causes acute tubular necrosis
from kidney ischemia/toxins
*pre renal failure is most common
What is seen with interstitial nephritis
WBC casts + eos + hematuria
How do you diagnose interstitial nephritis
renal biopsy, discontinue offending drug, steroids, dialysis if needed, usually self-limiting
What are the common causes of glomerulonephritis
group A strep, IGA, anti-GBM, ANCA
what is the MC infectious cause of acute glomerulonephritis
post strep glomerulonephritis
- either from strep pharyngitis or strep skin infection (impetigo)
What is the gold standard for diagnosing CKD
measurement of GFR
How is CKD managed
Blood pressure control < 130/80, ACE or ARB, A1c 6.5-7.5%
How will someone in CKD typically present
hypocalcemia, hyperphosphatemia, and metabolic acidosis
a 62-year-old man who presents to your office with a sudden onset of fever and rash. His review of systems is negative. He was recently started on omeprazole for acid reflux 14 days ago. Routine laboratory tests reveal a serum creatinine of 3.5 mg/dL and eosinophilia. Urine studies showed white blood cell casts. What is the likely diagnosis
Acute interstitial nephritis