urology 1 Flashcards

1
Q

what is testicular torsion?

A

Testicular torsion refers to twisting of the spermatic cord with rotation of the testicle. It is a urological emergency, and a delay in treatment increases the risk of ischaemia and necrosis of the testicle, leading to sub-fertility or infertility.

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2
Q

how does testicular torsion present?

A

The typical patient is a teenage boy, but it can occur at any age.

There may be a history of recurrent symptoms in patients where there is intermittent testicular torsion.

Testicular torsion is often triggered by activity, such as playing sports. Ask what the patient was doing at the time when the pain started.

It presents with an acute rapid onset of unilateral testicular pain, and may be associated with abdominal pain and vomiting. Sometimes abdominal pain is the only symptom in boys, and testicular examination to exclude torsion is essential.

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3
Q

what are the examination findings for testicular torsion

A

Examination findings are:

Firm swollen testicle
Elevated (retracted) testicle
Absent cremasteric reflex
Abnormal testicular lie (often horizontal)
Rotation, so that epididymis is not in normal posterior position

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4
Q

what is a bell-clapper deformity?

A

A bell-clapper deformity is one of the causes of testicular torsion.

Normally, the testicle is fixed posteriorly to the tunica vaginalis. A bell-clapper deformity is where the fixation between the testicle and the tunica vaginalis is absent. The testicle hangs in a horizontal position (like a bell-clapper) instead of the typical more vertical position. It is also able to rotate within the tunica vaginalis, twisting at the spermatic cord. As it rotates, it twists the vessels and cuts off the blood supply.

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5
Q

what is the management for testicular torsion?

A

urological emergency- urgent treatment.

Nil by mouth, in preparation for surgery
Analgesia as required
Urgent senior urology assessment
Surgical exploration of the scrotum
Orchiopexy (correcting the position of the testicles and fixing them in place)
Orchidectomy (removing the testicle) if the surgery is delayed or there is necrosis

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6
Q

what investigations can be done for testicular torsion?

A

A scrotal ultrasound can confirm the diagnosis. However, any investigation that will delay the patient going to theatre for treatment is not recommended. Ultrasound can show the whirlpool sign, a spiral appearance to the spermatic cord and blood vessels.

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7
Q

what is epididymo- orchitis?

A

Epididymitis is inflammation of the epididymis. Orchitis is inflammation of the testicle.

Epididymo-orchitis is usually the result of infection in the epididymis and testicle on one side.

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8
Q

what is the anatomical relationship and role of the epididymis testicle and vas deferent.

A

At the back of each testicle is the epididymis. Sperm are released from the testicle, into the head of the epididymis. The sperm travel through the head, then body, then tail of the epididymis.

Sperm mature and are stored in the epididymis. The epididymis drains into the vas deferens.

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9
Q

what are some causes of Epididymo-orchitis?

A

(E. coli)
Chlamydia trachomatis
Neisseria gonorrhoea
Mumps

TOM TIP: Think of mumps in patients with parotid gland swelling and orchitis. Mumps tends only to affect the testicle, sparing the epididymis. It can also cause pancreatitis.

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10
Q

what is the typical presentation of Epididymo-orchitis?

A

gradual onset, over minutes to hours, with unilateral:

-Testicular pain
-Dragging or heavy sensation
-
Swelling of testicle and epididymis
-Tenderness on palpation, particularly over epididymis

  • Urethral discharge (should make you think of chlamydia or gonorrhoea)
  • Systemic symptoms such as fever and potentially sepsis
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11
Q

what is the key differential diagnosis of epididymo-orchitis?

A

testicular torsion.

Both present similarly, with acute onset of pain in one testicle. If there is any doubt, treat it as testicular torsion until proven otherwise.

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12
Q

The key with epididymo-orchitis is to distinguish whether the cause is likely to be an enteric organism (e.g., E. coli) or a sexually transmitted organism (e.g., chlamydia or gonorrhoea).

The features that make a sexually transmitted organism more likely are:

A

Age under 35
Increased number of sexual partners in the last 12 months
Discharge from the urethra

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13
Q

what are investigations that can be used to establish the diagnosis of epididymo-orchitis?

A
  • Urine microscopy, culture and sensitivity (MC&S)
  • Chlamydia and gonorrhoea NAAT testing on a first pass urine
  • Charcoal swab of purulent urethral discharge for gonorrhoea culture and sensitivities
  • Saliva swap for PCR testing for mumps, if suspected
  • Serum antibodies for mumps, if suspected (IgM – acute infection, IgG – previous infection or vaccination)
  • Ultrasound may be used to assess for torsion or tumours
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14
Q

what is the management of epididymo-orchitis?

A

Acutely very unwell or septic patients are admitted to hospital for treatment (IV antibiotics).

Patients with a high risk of sexually transmitted infection should be referred urgently to genitourinary medicine (GUM) for assessment and treatment.

For patients that are at a low risk of STIs, a typical choice is:

Ofloxacin (usually first-line) for 14 days

Alternatives:

Levofloxacin / ciprofloxacin
Doxycycline
Co-amoxiclav

Additional measures:

Analgesia
Supportive underwear
Reduce physical activity
Abstain from intercourse

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15
Q

: Quinolone antibiotics such as ofloxacin, levofloxacin and ciprofloxacin are powerful broad-spectrum antibiotics, often used for urinary tract infections, pyelonephritis, epididymo-orchitis and prostatitis. They give excellent gram-negative cover. It is worth remembering two critical side effects, as these may be tested in exams and are essential to inform patients about:

A
  • Tendon damage and tendon rupture, notably in the Achilles tendon
  • Lower seizure threshold (caution in patients with epilepsy)
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16
Q

what are some key causes of scrotal or testicular lumps?

A
Hydrocele
Varicocele
Epididymal cyst
Testicular cancer
Epididymo-orchitis
Inguinal hernia
Testicular torsion
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17
Q

why is a hydrocele, how does it present and what causes it?

A

A hydrocele is a collection of fluid within the tunica vaginalis that surrounds the testes.

usually painless and present with a soft scrotal swelling.

Examination findings with a hydrocele are:

  • The testicle is palpable within the hydrocele
  • Soft, fluctuant and may be large
  • Irreducible and has no bowel sounds (distinguishing it from a hernia)
  • Transilluminated by shining torch through the skin, into the fluid (the testicle floats within the fluid)

Hydroceles can be idiopathic, with no apparent cause, or secondary to:

Testicular cancer
Testicular torsion
Epididymo-orchitis
Trauma

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18
Q

what is the management for a hydrocele

A

Management involves excluding serious causes (e.g., cancer).

Idiopathic hydroceles may be managed conservatively.

Surgery, aspiration or sclerotherapy may be required in large or symptomatic cases.

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19
Q

why is a varicocele?

A

A varicocele occurs where the veins in the pampiniform plexus become swollen.

cause impaired fertility, may result in testicular atrophy, reducing the size and function of the testicle.

Varicoceles are the result of increased resistance in the testicular vein–>Incompetent valves .

The pampiniform plexus drains into the testicular vein. It plays a role in regulating the temperature of blood entering the testes by absorbing heat from the nearby testicular artery.

The testicles need to be at an optimum temperature for producing sperm.

20
Q

In which testicle do most varicoceles occur?

A

Most varicoceles (90%) occur on the left due to increased resistance in the left testicular vein. A left-sided varicocele can indicate an obstruction of the left testicular vein caused by a renal cell carcinoma.

The right testicular vein drains directly into the inferior vena cava. The left testicular vein drains into the left renal vein.

21
Q

how do varicoceles present and what are the examination findings?

A

Varicoceles may present with:

Throbbing/dull pain or discomfort, worse on standing
A dragging sensation
Sub-fertility or infertility

Examination findings are:

A scrotal mass that feels like a “bag of worms”
More prominent on standing
Disappears when lying down

Varicoceles that do not disappear when lying down raise concerns about retroperitoneal tumours obstructing the drainage of the renal vein. These warrant an urgent referral to urology for further investigation.

22
Q

what investigations would you consider in varicoceles

A

Investigations to consider are:

Ultrasound with Doppler imaging can be used to confirm the diagnosis

Semen analysis if there are concerns about fertility

Hormonal tests (e.g., FSH and testosterone) if there are concerns about function

23
Q

how are varicoceles managed?

A

Uncomplicated cases can be managed conservatively.

Surgery or endovascular embolisation may be indicated for pain, testicular atrophy or infertility.

24
Q

where on the epididymis is an epididymal cyst usually found? and what is it called it it contains sperm?

A

head of the epididymis (at the top of the testicle).

An epididymal cyst that contains sperm is called a spermatocele. Management of epididymal cysts and spermatoceles is identical.

25
Q

how do epididymal cysts present and what are the examination findings?

A

Patients may present having felt a lump, or they may be found incidentally on ultrasound for another indication.

Examination findings are:

Soft, round lump 
Typically at the top of the testicle
Associated with the epididymis
Separate from the testicle
May be able to transilluminate large cysts (appearing separate from the testicle)
26
Q

management of an epididymal cyst

A

Usually, they are entirely harmless and are not associated with infertility or cancer. Occasionally, they may cause pain or discomfort, and removal may be considered. Exceptionally rarely, there may be torsion of the cyst, causing acute pain and swelling.

27
Q

which type of cells does testicular cancer arise from and who is usually affected?

A

germ cells and young men

28
Q

testicular cancer can be divided into two types?

A

seminomas and non seminomas

29
Q

what are risk factors for testicular cancer?

A

undescended testes
male infertility
family history
tall height

30
Q

how does a testicular lump usually present

A

painless Lump
which is hard and irregular in shape

Rarely, gynaecomastia (breast enlargement) can be a presentation of testicular cancer, particularly a rare type of tumour called a Leydig cell tumour. About 2% of patients presenting with gynaecomastia have a testicular tumour.

31
Q

what is the initial investigation for testicular cancer and what are the tumour markers of testicular cancer?

A

ultrasound

AFP
Beta- HCG
lactose dehydrogensase (very non- specific tumour marker).

A staging CT scan can be used to look for areas of spread and to stage the cancer.

32
Q

what is the staging system for testicular cancer

A

Stage 1 – isolated to the testicle
Stage 2 – spread to the retroperitoneal lymph nodes
Stage 3 – spread to the lymph nodes above the diaphragm
Stage 4 – metastasised to other organs

33
Q

where are common places of testicular cancer mets

A

Lymphatics
Lungs
Liver
Brain

34
Q

what is the prognosis of testicular cancer like?

A

The prognosis for early testicular cancer is good, with a greater than 90% cure rate.

35
Q

what is the typical presentation of bladder cancer?

A

!!painless haematuria!!!!

The typical presentation to look out for in your exams is a retired dye factory worker with painless haematuria. Whenever an exam question mentions a patient’s occupation, it is almost certainly relevant and will tell you the diagnosis. Dye factory workers get transitional cell carcinoma of the bladder. Patients with asbestos exposure get mesothelioma. Outdoor workers with significant sun exposure get skin cancer.

36
Q

what are risk factors for bladder cancer (mostly transitional cell carcinoma)?

A
  • smoking
  • increased age

Aromatic amines are worth noting as a carcinogen that causes bladder cancer. Aromatic amines were used in dye and rubber industries but have been heavily regulated or banned for many years. They are also found in cigarette smoke and seem to be the reason smoking causes bladder cancer.

37
Q

how do you diagnose bladder cancer? 1

A

-cytoscopy ( a camera through the urethera into the bladder).

38
Q

What is the most common treatment for bladder cancer?

A

Transurethral resection of bladder tumour (TURBT) may be used for non-muscle-invasive bladder cancer. The involves removing the bladder tumour during a cystoscopy procedure.

39
Q

risk factors for renal cell carcinoma?

A
Smoking
Obesity
Hypertension
End-stage renal failure
Von Hippel-Lindau Disease
Tuberous sclerosis
40
Q

Differentials for heamturia

never a normal finding

A
  • bladder cancer
  • renal cell carcinoma
  • urothelial carcinoma or -prostate adenocarcinoma

-renal calculi/kidney stones

Infection (UTIs), including pyelonephritis, cystitis (uni), or prostatitis

-trauma to the kidneys or urethera

Glomerulonephritis – often associated systemic disease (e.g. SLE)

BPH – painless, haematuria, recurrent UTI, associated obstructive symptoms.

Renal TB – (rare) – may be associated weight loss / anorexia, and sterile pyuria (urine that contains pus)
Polycystic disease – (rare)
Renal infarction – (rare)

41
Q

what is the difference between initial and terminal

haematuria?

A

Initial haematuria – this is presence of blood in the urine when you first start micturating – this implies urethral damage

Terminal haematuria – this is the presence of blood in the urine at the end of the stream, and this suggests a problem with the prostate or bladder base.

42
Q

how would you investigate haematuria?

A

FBC – to test for infection, and chronic blood loss
Clotting – to exclude an underlying bleeding cause
U+E – to asses renal function
MSU – to check for infection and parasites
Csytoscopy – if suspect a bladder cause
Autoimmune scan – if suspect glomerulonephritis
Intravenous Urography (IVU) / CT scan / ultrasound – if you suspect a renal cause

43
Q

risk factors for renal cell carcinoma?

A
Smoking
Obesity
Hypertension
End-stage renal failure
Von Hippel-Lindau Disease
Tuberous sclerosis
44
Q

how does renal carcinoma present?

A

Renal cell carcinoma may be asymptomatic, but may present with:

Haematuria
Vague loin pain
Non-specific symptoms of cancer (e.g., weight loss, fatigue, anorexia, night sweats)
Palpable renal mass on examination

45
Q

what are cannonball metastases and what causes it?

A

“Cannonball metastases” in the lungs are a classic feature of metastatic renal cell carcinoma. These appear as clearly-defined circular opacities scattered throughout the lung fields on a chest x-ray.

TOM TIP: Remember cannonball metastases as originating from a renal cell carcinoma. It is worth looking at some images of cannonball metastases. They are an exam favourite and an easy question to get right if you know the answer. They can also appear with choriocarcinoma (cancer in the placenta) and, less commonly, with prostate, bladder and endometrial cancer.

46
Q

what are some paraneoplastic syndromes associated with renal cell carcinoma?

Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to a cancerous tumor known as a “neoplasm.”

A

Polycythaemia – due to secretion of unregulated erythropoietin

Hypercalcaemia – due to secretion of a hormone that mimics the action of parathyroid hormone

Hypertension – due to various factors, including increased renin secretion, polycythaemia and physical compression

Stauffer’s syndrome – abnormal liver function tests (raised ALT, AST, ALP and bilirubin) without liver metastasis

47
Q

what is the most common cancer in men vs women

A

breast and prostate