Urologic Anatomy Flashcards
List the nerves of the lumbar plexus, their nerve roots, and their sensory and motor function?
“I I get laid on friday”
- Illiohypogastric (L1)
- Illioinguinal (L1)
- Genitofemoral (L1, L2)
- Lateral cutaneous nerve of the thigh (L2, L3)
- Obturator(L2-L4)
- Femoral (L2-L4)
List the nerve of the sacral plexus, its nerve root, and sensory and motor function?
- Sciatic (L4-S3) (branches into common peroneal, tibial, and sural)
List the nerve of the coccygeal plexus its nerve root, and sensory and motor function?
- Pudendal nerve (S2-S4)
Describe the path of a red blood cell from the renal artery to a glomerulus?
Renal artery -> segmental artery -> interlobar artery -> arcuate artery -> interlobular artery -> afferent artery -> glomerulus
List 8 functions of the kidney?
- Excretion of waste
- pH homeostasis
- Na+ homeostasis
- BP regulation
- Drug metabolism
- Erythropoetin
- Fluid balance
- Vitamin D homeostasis
List the paired and unpaired arteries that come off of the abdominal aorta from top to bottom?
- Inferior phrenic (paired)
- Celiac artery
- Adrenal artery (paired)
- SMA
- Renal artery (paired)
- Gonadal artery (paired)
- IMA
- Middle sacral
- Lumbars (posterior, paired and multiple)
What is the arterial supply to the testis?
- Testicular (gonadal) artery (from aorta)
- Cremasteric artery (from inferior epigastric)
- Vas deferes artery (inferior vesical)
What are the contents of the spermatic cord (9)
Arteries (3) - Testicular, cremasteric, Vas
Nerves (3) - testicular, genital branch of gen-fem, illioinguinal
Veins (1) - pam-uniform plexus
Lymphatics (1) (drain into para aortic nodes)
Vas deferens (1)
What are the fascial layers of the spermatic cord and their analogous abdominal structures?
- External spermatic fascia (external oblique aponeurosis)
- Cremasteric muscle (internal oblique)
- Cremasteric fascia (internal oblique fascia)
- Internal spermatic fascia (transvalis fascia)
- Tunica vaginalis (peritoneum)
What are the layers of the scrotum and their analogous abdominal structures?
Skin - skin
Dartos - scarpas/colles fascia
External spermatic fascia - external oblique aponeurosis)
Cremaster muscle - internal oblique
Cremasteric fascia - int. oblique aponeurosis
Internal spermatic fascia - trasversali fascia
Tunica vaginalis - parietal peritoneum
Tunica albuginea - visceral peritoneum
What are the branches of the external iliac artery (5) in order from proximal to distal?
- Inferior epigastric
- Deep circumflex
- Pubic
- Cremasteric
- Femoral (end artery)
What are the branches of the internal iliac anterior division (from proximal to distal)?
- Obliterated umbilical artery
- Superior vesical artery
- Obturator artery
- Vaginal artery
- Inferior vesical artery
- Uterine artery
- Middle rectal artery
- Inferior gluteal artery
- Internal pudendal artery (terminal artery)
What are the branches of the internal pudendal artery?
- Inferior rectal artery
- Perineal artery
- Posterior scrotal
- Artery to bulb of penis
- Common penile (terminal artery)
What are the branches of the common penile artery?
- Dorsal artery
- Cavernosal artery
- Bulbourethral
What are the branches of the posterior division of the internal iliac artery?
- Ascending lumbar
- Lateral sacral
- Superior gluteal
- Inferior gluteal (terminal)
What are the borders of Petit’s triangle?
External oblique, latissimus dorsi, illiac crest, (floor is internal oblique)
What are the borders of the femoral triangle?
Inguinal ligament, sartorial and adductor longus. (floor: pectineus, illiopsoas, and adductor longus, roof: fascia lata))
What are the zones of the prostate?
Anterior, transitional, central, and peripheral.
What are the borders of the inguinal canal?
Roof - conjoint tendon (transversals fascia, internal oblique, and transversus abdominus.
Floor - inguinal ligament, lacunal ligament
Anterior wall - aponeurosis of the external oblique reinforced by the internal oblique muscle laterally
Posterior wall - transversalis fascia
Openings - superficial (exit from inguinal canal) and deep ring (opening to inguinal canal)
Main arterial supply to the bladder
Superior and inferior vesical pedicles from anterior trunk of internal iliac artery
Sympathetic innervation of the bladder
Hypogastric nerve T10-L2, innervates trigone, bladder neck
Parasympathetic innervation of the bladder
Pelvic nerve S2-4, innervates bladder
Somatic innervation of the bladder
Pudendal & Pelvic nerve, mainly S2, external sphincter/bladder
Embryologic structure that gives rise to the ureter, renal pelvis, collecting ducts
ureteral bud (also a derived from the mesonephric duct)
Embryologic structure that gives rise to the trigone
mesonephric duct, mesodermal structure
Embryologic structure that give rise to the bladder
urogenital sinus (an endodermal structure)
Describe the supraspinal vesicovesical (vesico-bulbo-vesical) reflex
- Bladder filling activates stretch receptors in the bladder wall that reach the spinal cord via pelvic nerve.
- Fibers connect in the dorsal horn that project to periaqueductal gray matter (PAG).
- PAG activates the pontine micturition center (PMC) that project directly to the bladder via preganglionic neurons in the Sacral PNS then back to pelvic nerves to activated PNS in the pelvic plexus releasing Ach stimulating M2 M3 receptors.
Describe the Vesico-spinal-vesical reflex
Occurs when there is a lesion rostral to the to lumbosacral level that interrupts the vesico-bulbo-vesical reflex. An automatic vesico-spinal-vesical micturition relex develops.
Describe the somatic storage reflex (pelvic to pudendal reflex)
Also called the guarding reflex
During normal storage, this reflex is initiated when there is a sudden increase in valsalva or intraabdominal pressure. Afferent signals travel to the spinal cord (also to the PAG then PMC) via pelvic nerve which activate efferent somatic urethral motor neurons in the Onufs nucleus. Motor neurons in this nucleus are activated which have axons that travel in pudendal nerve and release Ach which activates the rhabdosphincter.
What is the Pronephros?
Initial phase of embryologic kidney development. develops first 4 weeks of gestation. Degenerates by the end of the 5th week.
What is the Mesonephros?
2nd phase of embryologic kidney development. Develops as a persistence of the pronephros duct. Drains into the urogenital sinus and serves as primary excretory organ in weeks 4 -8. Mesonephric tubules develop by 16 weeks while mesonephros regresses.
Which elements of the mesonephros persists at week 16 of gestation?
Efferent tubules of the testis in men, nonfunctional mesosalpingeal in women (Epoohoron, and paroophoron)
What is the metanephros?
Final phase of embyrologic kidney development. Starts in sacral region as the ureteric bud originates from mesonephric duct. Metanephric mesenchyme condenses from intermediate mesoderm during 5th week which is induced by the ureteric bud to form the metanephric kidney.
When is nephrogenesis completed?
32 - 34 weeks gestation.
Which structures are derived from the metanephric mesenchyme?
glomerulus, proximal tubule, Loop of henle, and distal tubule
Ultimate fate of the ureteric bud
After successive division will develop to form the collecting system consisting of the collecting duct, calyces, renal pelvis, and ureter.
Length of right renal pelvis
2 - 4 cm
Length of the left renal pelvis
6 - 10 cm
Embryologic germ layer forming the adrenal cortex
Mesoderm
What are the layers of the adrenal gland and their associated function
Zona glomerulosa: - produces mineralcorticoids (aldosterone).
Zone fasiculata: - produces glucocorticoids (cortisol)
Zona Reticularis: - Synthesizes sex hormones (androgens)
Embryologic germ layer forming the adrenal medulla
ectoderm and develops from migrating cells of the neural crest.
Function of the adrenal medulla
Secretes neuroactive catecholamines (under sympathetic control).
Which nerves provide innervation to the adrenal gland
Sympathetic visceral nervous system
- preganglionic sympathetic fibers from lower T and L spinal cord via sympathetic chain innervates cortex
- Visceral afferent fibers from the celiac ganglia traverse cortex to the medulla.
What are chromaffin cells
Found in the adrenal medulla, are post ganglionic sympathetic neurons that have lost their axons and dendrites
General length of ureters
22 - 30 cm, 1.5 - 6 mm in diameter
Blood supply to the ureter
Upper: arterial branches from renal artery, gonadal artery, abdominal artery, common iliac,
Lower: Internal iliac, including vesical, uterine, middle rectal, vaginal arteries.
Does normal ureteral peristalsis require autonomic input?
No. Peristalsis is thought to originate and propagge from intrinsic from smooth muscle pacemaker sites in the minor calyces of the collecting system.
3 segments of the ureter
Upper: renal pelvis to upper boarder of sacrum
Middle: Upper to lower boarder of the sacrum
Lower: Lower sacrum to bladder
Innervation to the female urethra
Somatic and autonomic nerves that travel near urethra in vaginal walls.
Smooth muscle control under parasympathetic control
Pudendal and pelvic somatic nerves innervate striated urethral sphincter.
Lymphatic drainage female urethra. Distal vs proximal.
Distal urethra and labia drain to the superficial and deep inguinal nodes
Proximal urethra drains to iliac, obturator, pre-sacral, para-aortic nodes
Blood supply to the female urethra
Internal pudendal, vaginal , and inferior vesical arteries
Blood supply to male urethra
Internal pudendal artery becomes common penile artery
- two become dorsal artery and urethral artery to supply the male urethra
- Prostatic branches off of the inferior vesical and middle rectal arteries to supply the prostatic urethra
Lymphatic drainage of male urethra
Distal: superficial inguinal LN
Bulbar, membranous, prostatic urethra: iliac, obturator, presacral LN
Innervation to the male urethra
Pudendal nerve supply motor and sensory innervation. Autonomic innervation arises from pelvic plexus.
Penis blood supply:
Arises from femoral artery–> left/right superficial ext pudendal–> skin of penis
Internal pudendal
- First branch–> bulbourethral artery supplies the perineal membrane, and enters sponsgiosum to supp;ly the urethra, spongiosum and glans.
- Cavernosal arteries
- Dorsal artery: travels b/t deep dorsal vein and dorsal nerve. Circumflex artery branches off and supplies spongiosum and urethra
Penile lymphatic drainage
Skin and shaft drain to bilateral superficial inguinal nodes
Glans drain to deep inguinal lymph nodes.
Blood supply to prostate and seminal vesicles
Inferior vesical artery. First prostatic branch of the artery is the urethral artery that enters the gland posteriorlaterally at 5 & 7 o clock
Venous drainage of the Prostate and seminal vesicles
composed of inferior vesical veins that feed into the internal iliac vein.
Batsons venous plexus
network of valveless veins that connect the internal iliac to the vertebral vein plexus. This is thought to provide a route for bony mets.
Lymphatic drainage of the prostate
Obturator and internal iliac lymph node chains. Additional drainage through the external iliac and pre-sacral nodes.
4 factors that alter GFR
- Transglomerular hydrostatic pressure
- Renal plasma flow
- Glomerular permeability
- Oncotic pressure
Transglomerular hydrostatic pressure
Most significant determinant of GFR. regulated by afferent and efferent arterioles which are independent of systemic blood pressure.
Directly related to GFR
renal plasma flow. When RPF increases GFR increases and vice cersa
3 Phases of Unilateral ureteral obstruction
Phase 1: 1-2h, both RBF and Ureteral pressure increases + vasodilation of afferent arteriole increases RBF.
Phase 2: lasts 2-3h. Increased rise in ureteral pressure, RBF begins to decrease. ACE-I mitgates the decline in GFR and RBF,
Phase 3: 5 hours after obstruction. RBG and ureteral pressure decline. d/t increase in afferent arteriole resistance. RBF shifts from outer cortex to medullary regions resulting in lack of perfusion to the glomeruli –> reduced GFR. RBF gradually decreases over time.