URINE Flashcards
Urine is composed of _% of water and _% solutes
95% water 5% solutes
Major inorganic component of urine
Chloride
Second major inorganic component of urine
Sodium
Major organic component of urine
Urea
Approximately _____mL of urine is excreted daily
600-2000mL
Increased urine output
Polyuria
Decreased urine output
Oliguria
complete cessation of urine flow
Anuria
refers to painful urination
Dysuria
increased excretion of urine at night
Nocturia
Normal day to night ratio of urine is
2:1
Yellow color of urine is caused by the presence of the pigment
Urochrome
Urochrome excretion is increased when there is……
Fever, thyrotoxicosis, starvation
pink colored pigment and is most evident in specimens that have refrigerated
Uroerythrin
an oxidation product of the normal urinary constituent urobilinogen, imparts orange-brown color to urine
urobilin
smoky red brown urine that has intact RBCs
Hematuria
serves as an indicator of how well hydrated a person; gives a rough estimation of urine concentration
Urine color
Port wine or burgundy color urine indicates the presence of
porphyrins
color of urine in lead poisoning (lead porphyrinuria)
Yellow
color of urine in px with DI or DM
Pale yellow
urine specimen should be delivered to the lab and tested within
2 hours
what will increase in unpreserved urine
odor, pH, bacteria, nitrite (pos)
functional unit of the kidney
nephron
normal adult blood posses through the kidney at a rate of
1200ml/min
Renal plasma flow is equivalent to
600-700mL
are arterioles that will carry blood towards the nephrons
Afferent arterioles
renal _____ will deliver blood to the nephrons
renal artery
renal _____ will take away the blood from the nephrons
renal vein
filtering apparatus of the nephrons
glomerulus
glomerulus produces a filtrate with constant SG of _____ and a pH of ____
1.010
7.4
are responsible for concentrating and diluting the urine
renal tubules
majority of the reabsorption processes occurs in the
proximal convoluted tubule
permeable to water but impermeable to salt
Descending loop of Henle
permeable to salt but impermeable to water
Ascending loop of Henle
ADH acts in the ___________ and ___________ to promote water reabsorption
DCT and Collecting ducts
glomerulus is ______ charged
negatively
what can be filtered by the PCT
“WAGE”
water
amino acids
glucose
electrolytes
this test is no longer used because it is affected by diet and because 40% of urea is reabsorbed by the tubules
Urea clearance test
gold standard for assessment of GFR
inulin clearance test
most commonly used method to assess GFR
creatinine clearance test
creatinine clearance test requires:
24 hrs urine
serum / plasma
most commonly used test that assess tubular reabsorption test
Specific gravity
more sensitive test that assess tubular reabsorption test since it is only affected by the number of particles
Osmolarity / osmolality
what are the tests that assess tubular secretion
PAH test
Titratable acidity
urinary ammonia
urine pH
Phenolsulfonpthalein
normal pH of a random urine
4.5 - 8.0
most common colligative property of osmometers
freezing point
pH reagent strip principle
double indicator system
pH uses what color indicator
methyl red and bromthymol blue
Protein reagent strip principle
protein error of indicator
protein uses what color indicator
tetrabromphenol blue
confirmatory test for protein in the urine
3% Sulfosalicylic acid
Bence jones protein is seen in px with
multiple myeloma
glucose reagent strip principle
double sequential enzymatic reaction
reagents of glucose in reagent strip
glucose oxidase and peroxidase,
chromogen
Detects for reducing sugars
Copper reduction tests
Benedict’s test and Clinitest tablet test
high blood glucose and positive for urine glucose
HAG - hyperglycemia associated glycosuria
+ urine glucose caused by PCT defect
renal associated glycosuria (RAG)
ketone reagent strip principle
sodium nitroprusside
forms of ketones and its percent
B-hydroxybutyric acid - 78%
acetoacetic acid - 20%
acetone - 2%
Tablet for ketones that can be used in serum, urine and other body fluids
acetest tablets
blood reagent strip principle
pseudoperoxidase activity of the heme
reagent used in blood reagent strip
tetramethyl benzidine
urobilinogen reagent strip principle
ehlrich rxn or diazo reaction
the only test that you will never report as negative or positive only normal or increased
urobilinogen
Bilirubin reagent strip principle
diazo reaction
More sensitive bilirubin test than reagent strip
ictotest tablet
nitrite reagent strip principle
Greiss reaction
normal specific gravity
1.002 - 1.035
LE reagent strip principle
ester-diazo rxn
very high SG indicates the presence of
Radiographic contrast media
principle of dipstick reader
reflectance optometry