urinary tract infections Flashcards
are women or men more at risk of UTIs?
women
what are the defence mechanisms of the urinary tract
- commensal bacteria (e.g. vaginal lactobacilli)
- general immune system
- urine -> pH, chemical content and flushing mechanism
- uriteric peristalsis
- emptying of bladder
what can severe UTI result in
loss of renal function
how does UTI infectionn spread
ascending route -> from urethra to bladder
what is the most common pathogen implicated in UTI
E.coli
uncomplicated vs complicated UTI
uncomplicated - normal urinary tract
complicated - functional or anatomical abnormality, presence of catheter
what is an isolated UTI
no previous UTI for 6 month
what is a recurrent UTI
> 2 infections in 6 months or >3 in 12 months
acute lower UTI presentaiton
- dysuria
- urgency
- frequency
in elderly or those with indwelling catheters it may be asymptomatic
causes for recurrent UTIs (2)
- relapses caused by the same strain of organism (inadequate mgx)
- re-infection by different organisms
what can reccurent UTIs result in
chronic inflammatory changes in the bladder, prostate and periurethral glands
what is cystitis
an infection of the bladder
symptoms of cystitis (5)
- Frequency and urgency
- Suprapubic pain on postponing
- Dysuria
- Foul smelling discoloured urine
- Mild systemic upset
cystitis mgx (6)
non pharmacalogical:
1. fluids
2. alkalinisation of urine (potassium citrate)
pharma:
3. trimethoprim 200mg qds
4. nitrofurantoin 5-100mg qds
5. fosfomycin
6. cefalexin 250mg TDS
what bacteria are commonly implicated in complicated UTIs (4)
- enterobacteria e.g. proteus spp, klebsiella spp, citrobacter spp, enterobacter spp
- pseudomonas aeruginosa
- GBS
- candida spp (yeast)
what bacteria are commonly implicated in uncomplicated UTIs
- E.coli
- enterobacteria (K.pneumoniae)
- S.saprophyticus
what abx should NOT be given in UTIs
amoxicillin -> due to risk of resistance
what abx can be given in cystitis (4)
- nitrofurantoin
- trimethoprim
- cephalexin
- fosfomycin
what abx should not be given in pyelopnephritis
- nitrofurantoin
- fosfomycin
- pivmecillinam
- cephalexin
what abx should be used for pyelonephritis
IV gentamicin
what abx can be used in pseudamonas urinary tract infection (6)
- IV gentamicin
- IV piperacillin/tazobactam
- IV aztreonam
- IV meropenem
- IV ceftazidime
- IV/PO ciprofloxacin
what must be done prior to starting abx
take specimins for culture and urinanalysis
can a pt with a catheter have a UTI
YES - all pts with catheters will have bacteriuria after 3 days or so -> make sure to take catheters into consideration when a pt presents with fever and confusion
mgx for recurrent UTI (10)
conservative:
1. good hygiene practices
2. drink plenty
3. void bladder after sex
4. timed voiding
medical:
5. cranberry capsules
6. D-mannose
7. topical oestrogen
8. Hiprex with vit C
9. intravesical glycosaminoglycans
10. low dose abx prophylaxis for 6 months