Urinary stones Flashcards

1
Q

3rd MC urinary tract D/O

A

Urinary stones

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2
Q

Urinary stones pop?

A

M > F (2.5:1)

30-50s

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3
Q

Urolithiasis def

A

Stone formations anywhere in urinary tract

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4
Q

Nephrolithiasis def

A

Stones in kidneys

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5
Q

Ureterolithiasis

A

Stones in the ureters

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6
Q

Urinary calculi composition

A

Polycrystalline aggregates of crystalloid/organic matrix

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7
Q

Basic pathophysiology of stone formation

A

Result of urinary supersaturation of solutes

-low fluid intake, low UA volume = high solutes

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8
Q

Most stones are compsed of?

A

Calcium = radiopaque

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9
Q

Most important factors of stone development

A

High protein/salt intake
Inadequate hydration
Sedentary

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10
Q

Geographic factors of stone development

A

High humidity

INC temp

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11
Q

Genetic predisposition condition? 3

A

Homozygous Cystinuria
Auto rec D/O
INC cysteine excretion

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12
Q

Acidic urine contributes to

A

Uric acid or cystine stones

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13
Q

Alkaline urine contributes to

A

UTI - urease producing organisms
-proteus / klebsiella
=strucite stones

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14
Q

5 major stone types

A
  1. Calcium oxalate
  2. Calcium phosphate
  3. Cystine
  4. Struvite AKA staghorn calculi
    (-Mg ammonium phosphate)
  5. Uric acid
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15
Q

MC urinary stone

A

Calcium Oxalate Stones

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16
Q

Calcium Oxalate pH range

A

5.5-6.5

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17
Q

Increased risks of developing Calcium Oxalate

A

High sodium/protein
Dehydrated
Hypercalceuria
Low urine citrate

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18
Q

XR attenuation of Calcium Oxalate?

A

Radiopaque

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19
Q

Citrate interaction w/ calcium

A
  1. UA citrate binds calcium
  2. Decreases calcium
  3. Prevents calcium phosphate/oxalate stones
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20
Q

Acidic urinary citrate level is?

A

Decreased

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21
Q

Alkalosis urinary citrate level is?

A

Increased

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22
Q

Calcium phosphate pH level

A

> 7.5 pH alakaline urine

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23
Q

Calcium phosphate Increased RFs?

A

High sodium/protein
Dehydration
Hypercalcuria
Low urine citrate

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24
Q

Calcium phosphate XR attenuation?

A

Radiopaque

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25
Q

Struvite stones are composed of?

A

Mg-ammonium-phosphate

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26
Q

Struvite stone MC pop?

A

Women w/ recurrent UTIs w/ urease producing bacteria

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27
Q

Types of urease producing bacteria?

A
Proteus / klebsiella
Pseudomonas
Providencia
Staph
Mycoplasma
28
Q

Struvite stone pH range?

A

> 7.2

29
Q

Struvite stone XR attenuation?

A

Radiopaque/radioense

30
Q

Struvite calculi develops where?

A

Upper urinary tract

W/in Renal pelvis extending into 2 calyces

31
Q

What is the only amino acid insoluble in urine?

A

Cystine

32
Q

Cystine stone pH of UA?

A

<5.5

33
Q

What type of genetic predisposition is cystinuria?

A

Auto rec D/O

34
Q

Cystine stone XR attenuation?

A

Radiolucent

35
Q

Uric acid stone RFs?

A

Hyperuricemia
Myeloproliferative D/O
Malig w/ uric acid forming
Abrupt/dramatic wgt loss

36
Q

Uric acid stone pH range?

A

<5.5

37
Q

Uric acid stone XR attenuation?

A

Radiolucent

38
Q

Obstructing stones S/S

A

Colic pain - radiates anteriorly over ABD
Sudden onset - may wake from sleep
Severe unremitting flank pain
Ass/w n/v
Pt constantly moving looking for position of comfort
Hematuria
CVA TTP

39
Q

As stones pass down ureters may change to?

A

Referred ipsilateral groin pain

40
Q

Stones lodged at ureterovesical jx S/S?

A

Urinary urgency.freq

Males - pain at penis tip

41
Q

Does size of stone correlate w/ S/S severity?

A

No

42
Q

DDx for stones?

A

Bleeding - clots=temp obstruct
Pyelonephritis - flank pain and fever (not expected unless obstruct w/ infection)
GYN flank pain - ectopic preg, preg, ruptured ovarian cyst, ovarian torsion.
AAA - ruptured or leaking
Mesenteric ischemia - ABD w/out peritonitis S/S initally
Herpes zoster - flank pain +rash/lesion - no hematuria
Drug-seeking - false pain/hematuria

43
Q

Urinary stone labs

A
UA 
-hematuria 90%
-pH <5.5 - uric acid/cysteine stones
-pH 5.5-6.8 - calcium oxalate stones
-pH >7.2 - struvite stones
-pH >7.5 - calcium phosphate stones
CHEM 17
STONE ANALYSIS - strainer
44
Q

Imaging gold standard for urinary stones?

A

Non-contrast CT

-all stones visible

45
Q

Stones seen on KUB XR

A

Calcium = radiopaque

Cannot exclude stone if NEG

46
Q

Renal U/S is a good alternative image if?

A

Pt is pregnant
Safe, good accuracy.
Not standard of care

47
Q

Acute TXT of asymptomatic pt w/ no infection

A

no TXT

48
Q

Majority of Acute TXT id conducted how? Intervention?

A

Outpatient Conservative-

  1. Hydration
    - INC H2O
    - IVF if needed
  2. Pain
    - NSAID,narcs
  3. Antimetic
    - Ondansetron/promethazine
  4. Alpha-blk agents (pass it)
    - Alfuzosin/tamsulosin
49
Q

What size stone typically pass spontaneosly?

A

<=5-6mm

50
Q

Stone referral indications

A
Infection
Obstruction 
Intractable pain (admit)
Persistent N/V
>=6mm size
Fails to pass w/in 4wks
Kidney ABNL/single
Pregnant
Immunocompromised
PMHx severe renal Dz
51
Q

Pt w/ obstructed urinary calculi w/ fever and infected urine req?

A

Emergent urologic eval and drainage

-pus under pressure-

52
Q

Extracorporeal shockwave Lithotripsy (ESWL) works best when?

A

Stones are in renal pelvis or upper 2/3 of ureter and size <1.5cm

53
Q

TXT of choice if stones require advanced intervention?

A

TOC = ESWL 75%

54
Q

Before performing a ESWL what is req?

A

D/C NSAIDs 3 days prior (decrease bleed risk0

55
Q

What may be used post ESWL to help facilitate stone passage?

A

Ureteral Stent

56
Q

Ureteroscopic stone extraction attribute?

A

Remove Stones in lower 1/3 of ureter (NL anatomy)

57
Q

Percutaneous nephrolithotomy attributes

A

Remove Stones in renal collecting system or upper 2/3 of ureter w/ size >2cm

58
Q

Open stone surgery is reserved for who?

A

Pts w/ complex anatomy, obstruction, large infected struvite stones

59
Q

Acute pts bottom line management

A
Push fluids (PO/IV)
Pain control
Confirm stone PRN 
Admit PRN
Refer PRN
60
Q

Recurrent stones lab w/u

A

24hr UA
-volume, pH, composition
Serum PTH and Uric acid
-R/O hyperparathyroidism or gout

61
Q

PVT strategies

Diet

A

DEC salt > INC Ca2+ UA
DEC protein > INC Ca2+ and DEC citrate in UA

Do not restrict Ca2+ intake (low calcium diet > increased risk of stones)

INC bran/water
-fiber > feceses Ca2+ excretion

Avoid soda
-high in phosphate > INC calcium phosphate formation

Avoid VIT-C >2g/day
-ascorbic acid metabolism = INC oxalate

62
Q

Reducing calcium in diet physiology

A
DEC dietary Ca2+ >
DEC oxalate binding in GI >
INC serum oxalate >
INC urinary oxalate > 
INC urinary calcium oxalate > stones
63
Q

Recommended ca2+ intake

A

RDA 1000-1200 MG/d

64
Q

Txt for recurrent stones

A

High UA calcium = thiazide diuretic (HCTZ, chlorthalidone) > DEC UA Ca2+

Low UA citrate or pH = potassium citrate therapy

  • raises citrate in Ca2+ stone formers
  • raises pH in uric acid/cystine stone formers
65
Q

Very important orevention strategy

A

Hydrate -water

66
Q

How much should a stone forming patient urinate?

A

1.5-2L/d

67
Q

F/U for chronic stone formers?

A

6mo- RPT 24H UA to assess respone to intervention
Q1yr CT to assess new forms
RPT Stone analysis if TXT fail