Urinary stones Flashcards
3rd MC urinary tract D/O
Urinary stones
Urinary stones pop?
M > F (2.5:1)
30-50s
Urolithiasis def
Stone formations anywhere in urinary tract
Nephrolithiasis def
Stones in kidneys
Ureterolithiasis
Stones in the ureters
Urinary calculi composition
Polycrystalline aggregates of crystalloid/organic matrix
Basic pathophysiology of stone formation
Result of urinary supersaturation of solutes
-low fluid intake, low UA volume = high solutes
Most stones are compsed of?
Calcium = radiopaque
Most important factors of stone development
High protein/salt intake
Inadequate hydration
Sedentary
Geographic factors of stone development
High humidity
INC temp
Genetic predisposition condition? 3
Homozygous Cystinuria
Auto rec D/O
INC cysteine excretion
Acidic urine contributes to
Uric acid or cystine stones
Alkaline urine contributes to
UTI - urease producing organisms
-proteus / klebsiella
=strucite stones
5 major stone types
- Calcium oxalate
- Calcium phosphate
- Cystine
- Struvite AKA staghorn calculi
(-Mg ammonium phosphate) - Uric acid
MC urinary stone
Calcium Oxalate Stones
Calcium Oxalate pH range
5.5-6.5
Increased risks of developing Calcium Oxalate
High sodium/protein
Dehydrated
Hypercalceuria
Low urine citrate
XR attenuation of Calcium Oxalate?
Radiopaque
Citrate interaction w/ calcium
- UA citrate binds calcium
- Decreases calcium
- Prevents calcium phosphate/oxalate stones
Acidic urinary citrate level is?
Decreased
Alkalosis urinary citrate level is?
Increased
Calcium phosphate pH level
> 7.5 pH alakaline urine
Calcium phosphate Increased RFs?
High sodium/protein
Dehydration
Hypercalcuria
Low urine citrate
Calcium phosphate XR attenuation?
Radiopaque
Struvite stones are composed of?
Mg-ammonium-phosphate
Struvite stone MC pop?
Women w/ recurrent UTIs w/ urease producing bacteria
Types of urease producing bacteria?
Proteus / klebsiella Pseudomonas Providencia Staph Mycoplasma
Struvite stone pH range?
> 7.2
Struvite stone XR attenuation?
Radiopaque/radioense
Struvite calculi develops where?
Upper urinary tract
W/in Renal pelvis extending into 2 calyces
What is the only amino acid insoluble in urine?
Cystine
Cystine stone pH of UA?
<5.5
What type of genetic predisposition is cystinuria?
Auto rec D/O
Cystine stone XR attenuation?
Radiolucent
Uric acid stone RFs?
Hyperuricemia
Myeloproliferative D/O
Malig w/ uric acid forming
Abrupt/dramatic wgt loss
Uric acid stone pH range?
<5.5
Uric acid stone XR attenuation?
Radiolucent
Obstructing stones S/S
Colic pain - radiates anteriorly over ABD
Sudden onset - may wake from sleep
Severe unremitting flank pain
Ass/w n/v
Pt constantly moving looking for position of comfort
Hematuria
CVA TTP
As stones pass down ureters may change to?
Referred ipsilateral groin pain
Stones lodged at ureterovesical jx S/S?
Urinary urgency.freq
Males - pain at penis tip
Does size of stone correlate w/ S/S severity?
No
DDx for stones?
Bleeding - clots=temp obstruct
Pyelonephritis - flank pain and fever (not expected unless obstruct w/ infection)
GYN flank pain - ectopic preg, preg, ruptured ovarian cyst, ovarian torsion.
AAA - ruptured or leaking
Mesenteric ischemia - ABD w/out peritonitis S/S initally
Herpes zoster - flank pain +rash/lesion - no hematuria
Drug-seeking - false pain/hematuria
Urinary stone labs
UA -hematuria 90% -pH <5.5 - uric acid/cysteine stones -pH 5.5-6.8 - calcium oxalate stones -pH >7.2 - struvite stones -pH >7.5 - calcium phosphate stones CHEM 17 STONE ANALYSIS - strainer
Imaging gold standard for urinary stones?
Non-contrast CT
-all stones visible
Stones seen on KUB XR
Calcium = radiopaque
Cannot exclude stone if NEG
Renal U/S is a good alternative image if?
Pt is pregnant
Safe, good accuracy.
Not standard of care
Acute TXT of asymptomatic pt w/ no infection
no TXT
Majority of Acute TXT id conducted how? Intervention?
Outpatient Conservative-
- Hydration
- INC H2O
- IVF if needed - Pain
- NSAID,narcs - Antimetic
- Ondansetron/promethazine - Alpha-blk agents (pass it)
- Alfuzosin/tamsulosin
What size stone typically pass spontaneosly?
<=5-6mm
Stone referral indications
Infection Obstruction Intractable pain (admit) Persistent N/V >=6mm size Fails to pass w/in 4wks Kidney ABNL/single Pregnant Immunocompromised PMHx severe renal Dz
Pt w/ obstructed urinary calculi w/ fever and infected urine req?
Emergent urologic eval and drainage
-pus under pressure-
Extracorporeal shockwave Lithotripsy (ESWL) works best when?
Stones are in renal pelvis or upper 2/3 of ureter and size <1.5cm
TXT of choice if stones require advanced intervention?
TOC = ESWL 75%
Before performing a ESWL what is req?
D/C NSAIDs 3 days prior (decrease bleed risk0
What may be used post ESWL to help facilitate stone passage?
Ureteral Stent
Ureteroscopic stone extraction attribute?
Remove Stones in lower 1/3 of ureter (NL anatomy)
Percutaneous nephrolithotomy attributes
Remove Stones in renal collecting system or upper 2/3 of ureter w/ size >2cm
Open stone surgery is reserved for who?
Pts w/ complex anatomy, obstruction, large infected struvite stones
Acute pts bottom line management
Push fluids (PO/IV) Pain control Confirm stone PRN Admit PRN Refer PRN
Recurrent stones lab w/u
24hr UA
-volume, pH, composition
Serum PTH and Uric acid
-R/O hyperparathyroidism or gout
PVT strategies
Diet
DEC salt > INC Ca2+ UA
DEC protein > INC Ca2+ and DEC citrate in UA
Do not restrict Ca2+ intake (low calcium diet > increased risk of stones)
INC bran/water
-fiber > feceses Ca2+ excretion
Avoid soda
-high in phosphate > INC calcium phosphate formation
Avoid VIT-C >2g/day
-ascorbic acid metabolism = INC oxalate
Reducing calcium in diet physiology
DEC dietary Ca2+ > DEC oxalate binding in GI > INC serum oxalate > INC urinary oxalate > INC urinary calcium oxalate > stones
Recommended ca2+ intake
RDA 1000-1200 MG/d
Txt for recurrent stones
High UA calcium = thiazide diuretic (HCTZ, chlorthalidone) > DEC UA Ca2+
Low UA citrate or pH = potassium citrate therapy
- raises citrate in Ca2+ stone formers
- raises pH in uric acid/cystine stone formers
Very important orevention strategy
Hydrate -water
How much should a stone forming patient urinate?
1.5-2L/d
F/U for chronic stone formers?
6mo- RPT 24H UA to assess respone to intervention
Q1yr CT to assess new forms
RPT Stone analysis if TXT fail