Urinary Incontinence Flashcards

1
Q

What are some urine storage symptoms

A

FUN:
* Frequency, Urgency (a sudden compelling desire to pass urine), Nocturia
* Urge incontinence (involuntary leakage accompanied/preceded by urgency)
* Stress incontinence (involuntary leakage on effort, exertion, sneezing or coughing)
* Nocturnal enuresis

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2
Q

What are some urine voiding symptoms

A

HIPST:
* Hesitancy (difficulty in initiating micturition), Intermittent stream, Poor stream (perception of reduced urine flow), Spitting or spraying, Terminal dribble

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3
Q

What is the micturition cycle

A
  • The storage and voiding of urine from the bladder is called the micturition cycle: As the bladder fills, it is able to expand and contract due to the detrusor muscle layer lining it and the layer of transitional epithelial cells lining it (which are abe to physically stretch out)
  • The detrusor muscle is innervated by muscarinic cholinergic nerves of the PNS
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4
Q

How much can the adult bladder hold

A

Around 750ml

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5
Q

What are the functions of the internal and external sphincter muscles

A
  • Internal sphincter muscle: Smooth muscle with involuntary control- opens when bladder is around half full (innervated by NA neurons of the SNS)
  • External sphincter muscle: Skeletal muscle under voluntary control (somatic fibres from pudendal nerves)
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6
Q

What happens as the bladder reaches capacity

A
  • Sensory signals from stretch receptors in the bladder wall send the impulses to spinal cord at levels S2 and S3 (micturition centre) and to the pons (pontine storage centre and pontine micturition centre)
  • Micturition reflex then occurs whereby internal sphincter relaxes
  • The pons then allows for voluntary delay of micturition until socially convenient (via cortical inhibition of spinal voiding reflex arc). To delay urination, pontine storage centre overrides micturition reflex, and to urinate, pontine micturition centre allows for micturition reflex to happen
  • In pre-menopausal women, the urethral epithelium has a rich blood supply and contributes to continence by acting as a seal
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7
Q

Important aspects of a general assessment of urinary incontinence

A
  • Ask about fluid intake and amount and type of fluids (e.g caffeine and alcohol)
  • Screen for red flag symptoms including: haematuria, persisting bladder or urethral pain, recurrent UTI, constant leakage (suggests fistula)
  • Ask about drugs that could be causing or exacerbating incontinence:
  • E.g Alpha-1 adrenoceptor antagonists, antipsychotics, anticholinergics, antidepressants, benzos, diuretics, HRT
  • Ask about previous history of Ix and Tx (urinary tract disorders, lower spinal surgery, prolapse or hysterectomy, gynaecological and obstetric Hx)
  • Consider and look for cognitive impairment
  • Perform urine dipstick analysis in all women presenting with urinary incontinence to test for blood, glucose, protein, leucocytes, and nitrites (then consider MSU if either nitrates or leukocytes or both are positive- can offer Abx in the meantime if symptomatic)
  • Perform a general examination noting factors such as weight, abnormalities of gait and indicators of neurological disease
  • Examine the abdomen for a palpable bladder or mass
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8
Q

How can the strength of the pelvic floor be graded (based on digital examination)

A
  • 0 = no contraction. No discernible muscle contraction.
  • 1 = flicker. A flicker or pulsation is felt under the examiner’s finger.
  • 2 = weak. An increase in tension is detected, without any discernible lift.
  • 3 = moderate. There is lifting of the muscle belly and elevation of the vaginal wall.
  • 4 = good. Increased tension and a good contraction elevate the posterior vaginal wall against resistance (pressure by the examining finger applied to the posterior vaginal wall).
  • 5 = strong. Strong resistance is applied to the elevation of the posterior vaginal wall. The examiner’s finger is squeezed and drawn into the vagina.
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9
Q

How can we assess for the severity of urinary incontinence

A
  • Ask how often the woman is incontinent, at what times, and during which activities
  • Ask about the use of pads (including size) or changing of clothing
  • Ask the woman to keep a bladder diary for a minimum of 3 days
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10
Q

Investigations for urinary incontinence

A
  • Urine Dipstick
  • Urinary diary
  • Post-micturition USS (preferred) or catheterisation to exclude chronic urine retention
  • Urodynamic testing (cystometry)
  • USS- exclude incomplete emptying, also checks for congenital abnormalities, calculi, tumours and detects cortical scarring of kidneys
  • CT urograms
  • Methylene dye test- leakage from places other than the urethra is seen e.g fistulae
  • Cystoscopy- inspection of the bladder cavity- exclude tumours, stones, fistulae, cystitis
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11
Q

Describe the process of urodynamic testing

A
  • Used to be done in all patient but high false-negative and carries risk of UTI
  • Based on recreating a micturition cycle whilst recording abdominal and bladder pressure
  • 1 Catheter placed into the bladder through the urethra and a second into the rectum
  • Bladder is filled with warm water and a commode measures leakage
  • Detrusor pressure = bladder pressure -abdominal pressure
  • When urgency is reported, filling is stopped and the patient performs various actions to provoke leakage (e.g. coughing, star jumps) before voiding
  • Stress incontinence= leakage is seen when abdominal pressures are increased with no change in detrusor pressure
  • Overactive bladder= detrusor contractions are seen in the filling phase
  • Should be reserved for patients who fail to respond to conservative treatment
  • DO NOT perform before primary surgery if stress incontinence is suspected
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12
Q

What might be identified on urodynamic testing

A
  • Detrusor Overactivity: presence of a detrusor contraction, with or without sensation, during the filling phase of urodynamics
  • Detrusor Overactivity Incontinence: leakage from the urethra in associated with a detrusor contraction and increase in bladder pressure
  • Urodynamic Stress Incontinence: leakage from the urethra in association with a rise in abdominal pressure (e.g. coughing) without a detrusor contraction (a sign of urethral sphincter weakness)
  • Mixed Incontinence: presence of both urodynamic stress incontinence and detrusor overactivity
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13
Q

Indications for referral of incontinence to a specialist

A
  • Persisting bladder or urethral pain
  • Palpable bladder on bimanual or abdominal examination after voiding
  • Clinically benign pelvic masses
  • Associated faecal incontinence
  • Suspected neurological disease or symptoms of voiding difficulty
  • Previous urology surgery
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14
Q

Definition of overactive bladder syndrome

A

Urgency, with or without urge incontinence, usually with frequency or nocturia, in the absence of proven infection. Characterised by involuntary detrusor contractions during the filling phase of micturition (either spontaneous or provoked by actions which increase abdominal pressure.)

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15
Q

Definition of urgency urinary incontinence

A

Involuntary leakage accompanied by, or preceded by, a sudden compelling urge to pass urine which is difficult to defer. UUI is part of the larger symptom complex of overactive bladder syndrome.

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16
Q

Causes of overactive bladder syndrome

A
  • Idiopathic in most women
  • In some cases, it is associated with systemic neurological conditions such as PD, MS, or injury to pelvic or spinal nerves
  • Some drugs may cause detrusor overactivity: Parasympathomimetic, antidepressants and HRT (diuretics can also increase urinary frequency)
  • Urinary urgency can be exacerbated by caffeinated, acidic, or alcoholic drinks
17
Q

Risk factors for overactive bladder syndrome

A

Obesity, T2DM, chronic UTIs (can increase symptoms)

18
Q

Presentation of overactive bladder syndrome

A
  • URGENCY +/- urge incontinence
  • Urge incontinence presents in overactive bladder syndrome where urethral sphincter is compromised or detrusor contractions are of a very high amplitude and overcome urethral resistance
  • Frequency and nocturia. Leak at night or at orgasm
  • Faecal urgency
19
Q

When should a woman be referred under 2 week wait with overactive bladder syndrome

A

When aged 45 years and over with: unexplained visible haematuria without UTI OR visible haematuria that is persistent or recurrent after successful treatment of UTI
OR is aged over 60 with visible haematuria

20
Q

Lifestyle advice for women with urgency urinary incontinence

A
  • Reducing caffeine intake — this may improve symptoms of urgency and frequency but not incontinence.
  • Fluid intake — advise the woman to avoid drinking either excessive amounts, or reduced amounts, of fluid each day.
  • Weight loss if the woman’s body mass index is 30 kg/m2 or greater.
  • Smoking
21
Q

Management of urgency urinary incontinence

A
  • Offer bladder training lasting for a minimum of 6 weeks as first-line treatment to women with urgency or mixed urinary incontinence
  • If women do not achieve satisfactory benefit from bladder retraining a combination medicines with bladder training should be considered

Anticholinergic (antimuscarinic) medication with the lowest acquisition cost should be used:
* Oxybutynin (immediate release)- do not offer to older women at risk of sudden deterioration in physical or mental health
* Tolterodine
* Darifenacin
* DO NOT offer flavoxate, propantheline or imipramine

Other medications:
* Can give Mirabegron if an antimuscarinic drug is contraindicated- may also consider as a 2nd line pharmacological treatment (contraindicated in uncontrolled HTN and CHD)
* Desmopressin (off-label indication) may be considered specifically to reduce nocturia in women with urinary incontinence avoid in cystic fibrosis and >65 with CVD/HD
* May offer intravaginal oestrogens to treat overactive bladder symptoms in postmenopausal women with vaginal atrophy

Bladder catheterisation should be considered for women in whom persistent urinary retention is causing incontinence, symptomatic infections or renal dysfunction

22
Q

What do women need to be advised before starting medication

A
  • That some adverse effects of anticholinergic medicines, such as dry mouth and constipation, may indicate that the medicine is starting to have an effect
  • That she may not see substantial benefits until she has been taking the medicine for at least 4 weeks and that her symptoms may continue to improve over time
  • That the long-term effects of anticholinergic medicines for overactive bladder on cognitive function are uncertain
23
Q

What should be avoided in treatment of urgency urinary incontinence

A

DO NOT offer absorbant containment products, hand-held urinals or toileting aids to treat urinary incontinence. Offer only as:
* A coping strategy pending definitive treatment
* As an adjunct to ongoing therapy
* For long-term management of urinary incontinence only after treatment options have been explored

24
Q

When should medication be reviewed

A

Medication should be reviewed after 4 weeks. If there is no or suboptimal improvement, or intolerable adverse effects, change the dose or try an alternative medicine for overactive bladder, and review again 4 weeks later

25
Q

How can urgency urinary incontinence be managed after 1st line treatments have failed

A
  • After a local MDT review, bladder wall injection with botulinum toxin type A (Causes partial paralysis of the bladder and detrusor muscle- reduces urgency and leakage)
  • Percutaneous sacral nerve stimulation (After MDT) (device is implanted into the back to stimulate sacral nerve innervation) if their symptoms have not responded to botulinum type A or they are not prepared to accept risk of needing catheterisation
  • May also consider augmented cystoplasty (bladder is made larger by adding intestinal tissue) and urinary diversion (urine flows through an opening in the abdomen into an external bag) as a last resort
26
Q

Definition of stress urinary incontinence

A

Involuntary leakage of urine on effort or exertion, or on sneezing or coughing. Indicates an incompetent urethral sphincter- most commonly caused by hypermobility.

27
Q

Risk factors for stress urinary incontience

A
  • Increasing age
  • Pregnancy and vaginal delivery- muscles and connective tissue can be weakened during delivery, additionally damage may occur to pudendal and pelvic nerves
  • Obesity- due to pressure on pelvic tissues and stretching + weakening of muscles and nerves from excess weight
  • Constipation- straining may weaken pelvic floor muscles
  • Family history- women whose mother or sisters are incontinent are more likely to develop stress incontinence
  • Smoking- associated with a chronic cough (ACE inhibitors for the same reason)

Deficiency in supporting tissues:
* Prolapse- not a cause of stress urinary incontinence, but may present concomitantly
* Hysterectomy- may damage pelvic floor muscles
* Oestrogen deficiency during menopause- keep tissues that influence normal pressure transmission in the urethra and maintain urethral transmissions that help to create a ‘seal’

28
Q

What is the pathophysiology of stress urinary incontinence

A
  • Increased intra-abdominal pressure leads to compression of the bladder and increased bladder pressure. Once this exceeds urethral pressure, the result is incontinence
29
Q

Investigations for stress urinary incontinence

A
  • Use a validated urinary incontinence-specific symptom and quality-of-life questionnaire when therapies are being evaluated (QUID scoring questionnaire)
30
Q

When should women be referred under 2 week wait with stress urinary incontinence

A

If the woman is aged 45 or over with unexplained visible haematuria without UTI OR visible haematuria with recurrent or persistent UTI

31
Q

What lifestyle advice should be given to women with stress urinary incontinence

A
  • Reducing caffeine intake — this may improve symptoms of urgency and frequency but not incontinence.
  • Fluid intake — advise the woman to avoid drinking either excessive amounts, or reduced amounts of fluid each day.
  • Weight loss if the woman’s body mass index is 30 kg/m2 or greater.
  • Smoking
32
Q

Management of stress urinary incontinence

A
  • Give a trial of at least 3 months supervised pelvic floor training (PFMT)- minimum of eight pelvic floor exercises performed three times per day
  • Electrical stimulation and/or biofeedback should be considered for women who cannot actively contract pelvic floor muscles to aid motivation and adherence to therapy

If unsuccessful, refer to urogynaecology, gynaecology, urology for further treatment:
* Colposuspention (higher chance of pelvic organ prolapse)- 70% rate of improval in symptoms 1-5 years after surgery. Neck of the bladder is lifted up and stitched in this position: 1-2 days in hospital, recovery time 6 weeks (can be laparoscopic or laparotomy- requires GA)
* Autologous rectus fascial sling- 75% improval rate. Sling of intestine supports the urethra. 1-2 days in hospital, recovery time 6 weeks (requires GA)
* Retropubic mid-urethral mesh sling (complications include pain and vaginal problems- discharge, bleeding, infection, dyspareunia)- 75% improval rate. Strip of plastic is placed behind the urethra. Recovery time 2 weeks (may be done under LA)

All have complications including damage to bladder, bowel and nerves, incomplete voiding, urgency incontinence, pelvic organ prolapse

32
Q

Management of stress urinary incontinence

A
  • Give a trial of at least 3 months supervised pelvic floor training (PFMT)- minimum of eight pelvic floor exercises performed three times per day
  • Electrical stimulation and/or biofeedback should be considered for women who cannot actively contract pelvic floor muscles to aid motivation and adherence to therapy

If unsuccessful, refer to urogynaecology, gynaecology, urology for further treatment:
* Colposuspention (higher chance of pelvic organ prolapse)- 70% rate of improval in symptoms 1-5 years after surgery. Neck of the bladder is lifted up and stitched in this position: 1-2 days in hospital, recovery time 6 weeks (can be laparoscopic or laparotomy- requires GA)
* Autologous rectus fascial sling- 75% improval rate. Sling of intestine supports the urethra. 1-2 days in hospital, recovery time 6 weeks (requires GA)
* Retropubic mid-urethral mesh sling (complications include pain and vaginal problems- discharge, bleeding, infection, dyspareunia)- 75% improval rate. Strip of plastic is placed behind the urethra. Recovery time 2 weeks (may be done under LA)

All have complications including damage to bladder, bowel and nerves, incomplete voiding, urgency incontinence, pelvic organ prolapse.
6 month follow up for all of these surgical procedures

33
Q

What treatment options exist if these first line measures are unsuccessful or unacceptable for the patient

A

Consider intramural bulking agents to manage stress urinary incontinence if alternative surgical procedures are not suitable for or acceptable to the woman. Explain to the woman that:
* These are permanent injectable materials
* Repeat injections may be needed to achieve effectiveness
* limited evidence suggests that they are less effective than the surgical procedures
* There is limited evidence on long-term effectiveness and adverse events

Duloxetine may be offered as second-line therapy if women prefer pharmacological to surgical treatment or are not suitable for surgical treatment
* SNRI - Enhances urethral striated sphincter activity via centrally mediated pathway

34
Q

Definition of overflow incontinence

A

Can be due to detrusor underactivity or bladder outlet obstruction causing urinary retention and leakage of urine. Acute urinary retention= unable to pass urine for 12hrs or more

35
Q

Definition of mixed incontinence

A

Incontinence with features of both urge and stress incontinence- should terat the most predominantly type