Urinary Drugs

Question 1

MOA of 2-MPG? Use?

Answer 1

Cystine inhibition for cystine urolithiasis.

Question 2

MOA of allopurinol?

Answer 2

Xantine oxidase inhibitor –> blocks conversion of xanthine to uric acid.

Question 3

Two MOA of amitryptilline?

Answer 3

Tricyclic antidepressant and anticholinergic - effects include antihistamine, antialpha adrengergic, antiinflammatory and analgesic

Question 4

MOA of bethanacol? Used to treat?

Answer 4

Parasympathomimetic agent - stimulates cholinergic and muscarinic receptors. Tx for detrusor muscle atony.

Question 5

Benzodiazpines - used to relax what?

Answer 5

Striated muscle

Question 6

How do estrogens and repro hormones improve urinary incontinence?

Answer 6

Enhance alpha-adrenergic receptor response/agonist and improves urethral vasculature

Question 7

How do GnRH analogues help with urinary incontinence?

Answer 7

Suppress FSH and LH

Question 8

MOA of oxybutinin? Use?

Answer 8

Anticholinergic. For uge incontinence (relaxes bladder muscle).

Question 9

MOA of phenypropanolamine?

Answer 9

Alpha agonist

Question 10

MOA of phenoxybenzamine? Use?

Answer 10

Nonselective alpha adrenergic antagonist/blocker; use for urethral smooth muscle relaxation

Question 11

MOA of prazosin?

Answer 11

Alpha-adrenergic antagonist

Question 12

MOA of potassium citrate? What does it do to the urine?Use?

Answer 12

Calcium oxalate inhibition; alkalinizes; useful for uric acid and cystine stones

Question 13

MOA od propanthaline? Use?

Answer 13

Anticholinergic; minimizes the force and frequency of uncontrolled detrusor contraction for inappropriate elimination.

Question 14

Main drugs for urethral incompetance?

Answer 14

Alpha agonists and repro hormones

Question 15

Main drugs for urinary retention?

Answer 15

Alpha antagonism

Question 16

Sympathetic innervation - ?
Parasympathetic innervation - ?
Somatic innervation - ?

Answer 16

Sympathetic - hypogastric nerve (beta terminate in the detrusor and stimulation causes relaxation and bladder filling; alpha innervates the smooth muscle of the urethra and trigone – contraction when stimulation (internal sphincter))
Parasympathetic - Pelvic nerve - stimualation leads to detrusor contration (P = pee = parasympathetic = pelvic)
Somatic - Pudendal - stimulation causes external uretral sphincter contraction