URI- common cold, influenza, pharyngitis Flashcards

1
Q

Common cold virology and timing

A
RHINOVIRUS- fall late spring
corona virus- winter/spring
influenza virus- fall late spring
parainfluenza
enterovirus- summer
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2
Q

common cold epidemiology

A

droplets

sneeze cough etc

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3
Q

common cold symptoms

A
rhinorrhea
nasal congestion
sore throat 
cough
malaise
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4
Q

common cold signs

A

nasal mucosal swelling

clear watery or purulent discharge

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5
Q

common cold diagnosis

A

clinical

based on symptoms and observed signs

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6
Q

common cold treatment

A
self limiting
supportive care 
analgesics
anitihistimines/decongestants- psedophedrine sudafed, diphenhydramine- benadryl
expectorants/antitussives- robitussen
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7
Q

Influenza epidemiology

A

influenza A and B virus
self limiting
mortality more common in >65 copd DM Cardiovascular disease

-deaths common due to secondary bacterial pneumonia

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8
Q

influenza transmission

A

aerosolized drops cough sneeze
hand to hand contact
incubation 1-4 d
peak viral shedding 48 hrs

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9
Q

influenza presentation

A
***
abrupt onset
fever up to 106
mylagia (muscle aches)
cough
sore throat
flushing
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10
Q

influenza who to test

A
when no known outbreak
immunocompetent pts after hospitalization
high risk
healthcare workers
ALL inpatient with symptoms
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11
Q

influeza whos high risk

A
>65
children less than 5 especially less than 2!
chronic illness
pregnant
native american
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12
Q

Inlfuenza diagnostics

A

done within 3-4 days
Rapid influenza detection tests (RIDTs)
-fast in office <15 min LOW sensitivity/ high specificity

Rapid molecular assay (nucleic acid amplification test, NAAT)
-lab or inpatient 45 min
high sensitivity/specificity

Reverse transcriptase polymerase chain reaction (RT-PCR)
1-8 hrs
high s/s

Viral culture

  • GOLD standard 3-10 days
  • not for initial clinical management
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13
Q

influenza management

A
antiviral within 48 hrs
neuraminidase inhibitors
-oseltamivir/tamiflu
-zanamivir/relenza
-peramivir/rapivab
-baloxavir/xofluza
give in pregnancy if suspected influenza A
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14
Q

forms of pharyngitis and which is most common

A

viral 80%
bacterial
noninfectious

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15
Q

pharyngitis viral

A
Rhinovirus
respiratory syncytial virus
adenovirus
coronavirus
influenza
usually fluid collects sometimes whitish
Herpes simplex 1&amp;2
treatment:  acyclovir, famciclovir
ask sexual history
hydration
magic mouthwash

Mononucleosis- epstein-barr virus (EBV)
sore throat, pharyngeal erythema, tonsillar exudates
fever
enlarged lymph nodes
SPLENOMEGALY 50%
2-4 week duration up to 3 months contageous
TX: Supportive, avoid contact sports

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16
Q

pharyngitis bacterial

A

CORYNEBACTERIUM DIPTHERIAE
gray exudate tightly adherent to throat, nasal passage
unvaccinated
recent travel
Tx: diptheria anti-toxin + penicllin or erythromycin
report

mycoplasma pneumoniae
lower resp. infection and HA significant cough
tx: azithromycin

neisseria gonorrhoeae
15% men sex with men
associated with oral sex
pharyngitis with exudates, cervical lad
tx: ceftriaxone (rocephin) 250 mg IM x 1
GROUP A STREPTOCOCCUS (GAS) often pyrogenes
local invasion otitis media, meningitis
immune mediated responses
sore throat 
odynophagia
fever, malaise, anorexia
pharyngeal erythema
purulent exudate
palatal petechiae
TONSILLAR EXUDATES, TENDER ANTERIOR CERVICAL ADENOPATHY, FEVER BY HISTORY, ABSENCE OF COUGH

RAPID ANTIGEN DETECTION TEST (RADT)
tx: penicillin G benzathine IM, penicillin V, amoxicillin, cephalexin (keflex)
pcn allergy then use azithromycin, clindamycin
no longer considered contagious after 24 of antibiotic

group C or G streptococcus
less common
same treatment

17
Q

complications of streptococcal pharyngitis

A

acute reheumatic fever
-2-3 w delayed sequela post infection
-usually strep wasnt treated
may result in cardiac valve abnormalities, arthritis

post-streptococcal glomerulonephritis
can progress to acute renal failure

Streptococcal toxic shock syndrome
shock and organ failure

scarlet fever
previous strep pyrogenes
-petechial lines on flexor surfaces(pastias lines) , "strawberry tonge"
facial flushing with circumoral pallor
*can predispose to rheumatic fever