Urethral Stricture Flashcards
What is the lining of the posterior urethra?
Transitional epithelium
What is the lining of the anterior urethra?
pseudostratified squamous epithelium
What is the lining of the fossa navicularis?
stratified squamous epithelium
What is narrowing of the posterior urethra called?
stenosis
What is narrowing of the anterior urethra called?
stricture
What are the two leading causes of urethral strictures in developed countries?
Idiopathic 41%
Iatrogenic 35%
What is the leading cause of urethral stricture in developing countries?
Trauma 36%
What are the common presenting symptoms of patients with urethral strictures?
Decreased urine stream Incomplete emptying UTI Epididymitis Decreased ejaculation
What should be included in the workup of a patient with slow stream?
Thorough history Physical exam UA Urine culture PVR Uroflow/UDS Cystoscopy RUG
What is the duration of foley catheter placement following surgery for urethral structure?
Typically 2-3 weeks after which a RUG or VCUG is obtained.
What are the possible sexual side effects of urethroplasty?
Ejaculatory dysfunction 21%
Erectile dysfunction 1%
What is the uroflow rate associated with urethral strictures?
Less than 12ml/s
What is recommended to confirm the diagnosis of a urethral stricture?
Urethroscopy
RUG
VCUG
US urethography
What is the diagnostic of choice for confirmation of urethral stricture?
RUG
What information is required before planning treatment for a stricture?
Length and location of the stricture.
What are the treatment options when a patient is in urinary retention and has a urethral stricture?
Suprapubic cystostomy
Urethral dilation
DVIU
What should be done before definitive management for a urethral stricture if urethroplasty is being considered?
4-12 weeks of urethral rest with suprapubic tube if necessary to allow full stricture to declare itself.
What are the treatment options and success rates for bulbar urethral strictures < 2cm?
Dilation (35-70%)
DVIU (35-70%)
Urethroplasty (80-95%)
How does DVIU compare to dilation when endoscopic management is desired?
Dilation and DVIU may be used interchangeably
What is the data regarding injection of steroids or mitomycin C at time of stricture treatment?
There is weak evidence to suggest that it decreases recurrence rate but stronger studies with long term follow up are needed.
When can catheters be removed safely following DVIU or dilation?
24-72 hours
What is the next step in a patient who just underwent a redo DVIU but is not a candidate for a urethroplasty?
They should be started on self catheterization as stricture recurrence rates were significantly lower among patients performing self-catheterization (risk ratio 0.51, 95% CI 0.32 to 0.81, p = 0.004
What is the next step in most patients who failed at least one endoscopic procedure for urethral stricture?
Urethroplasty
What is the failure rate for repeat endoscopic management of urethral strictures?
> 80%
What are the initial options for treatment of meatal or fossa navicularis strictures?
Dilation
Meatotomy
What factors may complicate tx of fossa navicularis/meatal strictures?
Hypospadias repair
Failed endoscopy
Urethroplasty
Lichen sclerosis
What initial tx can be used for meatal strictures due to LS?
extended meatotomy in conjunction with high-dose topical steroids
What should be done with the patient that has recurrent meatal or fossa navicularis strictures?
Surgeons should offer urethroplasty.
What is the success rate of uncomplicated meatotomy?
87%
What is the most common method of repair for the fossa navicularis?
Penile fasciocutaneous flap
Oral mucosa graft
What is the success rate of penile fasciocutaneous grafts?
94%
What is the success rate of oral mucosal grafts?
83-100%
What is the recommended treatment option for penile urethral strictures?
Urethroplasty
A patient has a bulbar urethral stricture >2cm. What is the preferred treatment?
Urethroplasty
A patient has Bulbar urethral stricture >4cm. How do the success rates between endoscopic tx and urethroplasty compare for these types of strictures?
Endoscopic: 20%
Urethroplasty: >80%
What is the first choice graft harvest site for urethroplasty?
The inner cheek
What is the problem with performing a single stage tubularized graft?
High rate of restenosis
What are the tx options for bladder neck contracture after endoscopic prostate procedure or vesicourethral anastomoses?
Dilation
bladder neck incision
TURBN
What is the success rate for first time tx of vesicourethral anastomotic strictures?
50-80%
What are the treatment options for patients on CIC for neurogenic bladder who develop a stricture?
Urethroplasty
Suprapubic tube
What should be done if lichen sclerosis is suspected?
Biopsy
What is the rate of squamous cell carcinoma in patients with lichen sclerosis?
2-8.6%
How should lichen sclerosis be treated?
Clobetasol
mometasone
What should be avoided when treating lichen sclerosis?
Avoid genital skin flaps
What should be done to evaluate the urethra in fracture urethral injuries?
retrograde urethrography, voiding cystourethrography (VCUG) and/or retrograde urethroscopy
A patient has a pelvic fracture urethral injury. What treatment is recommended
Delayed urethroplasty
What are the methods of gaining urethral length during an anastomotic urethroplasty?
- Mobilize the bulbar urethra
- Crural separation
- Inferior pubectomy and supracrural rerouting
- Transabdominal, transpubic.
What is the standard amount of time to wait after a pelvic fracture urethral injury before urethroplasty?
3-6 months.
What is the mucosal histology of the posterior urethra, anterior urethra, and fossa navicularis?
posterior: transitional epithelium
anterior: pseudostratified columnar epithelium
fossa navicularis: stratified squamous epithelium
What are presenting features of urethral stricture?
decreased urinary stream
incomplete bladder emptying
UTI
epididymitis
rising PVR
decreased force of ejaculation
dysuria
spraying
What important factors are there to consider for positioning during urethral stricture repair?
high lithotomy
avoid pressure on calf muscles, peroneal nerve and ulnar nerve
use SCDs to prevent VTE
After a urethral repair, what follow up imaging is recommended?
urethrography or VCUG 2-3 weeks after
replace catheter if persistent leak to avoid inflammation, urinoma, abscess, and/or urethrocutaneous fistula
Clinicians SHOULD include urethral stricture in ddx of men who present with which symptoms?
GUIDELINE STATEMENT 1
decreased urinary stream
incomplete emptying
dysuria
UTI
rising PVR
*stricture characteristics (length, diameter, duration of obstruction) lend to sxs
Risk factors for forming urethral stricture?
hypospadias surgery
urethral catheterization or instrumentation
traumatic injury
transurethral surgery
prostate cancer
idiopathic
inflammatory disorder (LS)
What non invasive measures can be performed initially in a patient with suspected urethral stricture?
GUIDELINE STATEMENT 2
H&P
UA
Uroflow
PVR
*AUA-SS
What evaluations would be next step to confirm diagnosis of urethral stricture after non-invasive measures?
GUIDELINE STATEMENT 3
Cysto
RUG
VCUG
US urethrography
MRI (can provide detail in certain cases, e.g diverticulum, fistula, cancer)
In planning non-urgent intervention for known stricture what must be determined:
GUIDELINE STATEMENT 4
length and location
Patients with symptomatic stricture including urinary retention or need for catheterization, may undergo which procedures urgently?
GUIDELINES STATEMENT 5
DVIU
SPT
GUIDELINE STATEMENT 6
surgeons may place SPT prior to definitive urethroplasty depending on CIC Or foley
“urethral rest” 4-12 weeks