Uptake and storage of other metals

Question 1

How are Cu and Zn stored?

Answer 1

In metallothionines (Cys rich)

Question 2

Uptake of Cr and V

Answer 2

Via anion channels as chromate and vanadate
Then reduced by glutathione
(But Cr(III) in cells can bind to DNA and act as a carcinogen)

Question 3

Is Cr essential?

Answer 3

Yes
Cr deficiency leads to impaired glucose tolerance
It is thought Cr binds to chromodulin as a carboxylate-bridged Cr4 cluster that then binds to the insulin receptors to stimulate glucose uptake

Question 4

Transport of other metals

Answer 4

Mugineic acid

Nature’s answer to EDTA