Upper GI Tract Flashcards

(47 cards)

1
Q

What marks the borders of upper GI

A

upper oesophageal sphincter to lower oesophageal sphincter

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2
Q

Anatomical contributions to lower oesophageal sphincter

A

3-4cm distal part of oesophagus is in abdomen

Diaphragm surrounds the sphincter (contracts against the sphincter)

Intact phreno-oesophageal ligament

Angle of His

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3
Q

How does the angle of His prevent reflux

A

The angle of His is an acute angle between the great curvature of the stomach and the oesophagus, and acts as an anti-reflux barrier by functioning like a valve

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4
Q

Why is an Intact phreno-oesphageal ligament important

A

ligament allows independent movement of the diaphragm and oesophagus during respiration and swallowing

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5
Q

4 stages of swallowing

A

Oral phase
Pharyngeal phase
Upper oesophageal phase
Lower oesophageal phase

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6
Q

Oral phase

A

Chewing + saliva prepare bolus

Both sphincter constricted

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7
Q

What is manometry

A

Way to record pressure of contractions of oesophagus + get an idea of its motility

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8
Q

what allows for relaxation of the sphincter - check this!

A

decreases LOS pressure - mediated by inhibitory noncholinergic noradrenergic neurons of myenteric plexus

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9
Q

What is absence of a stricture caused by

A

abnormal oesophageal contraction (hypermotility, hypomotility, disordered coordination)

Failure of protective mechanism for reflux (GORD)

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10
Q

Questions to ask about dysphagia

A

Location is important

Type of dyaphagia

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11
Q

Questions to ask abut dysphagia

A

Location is important (cricopharyngeal sphincter or distal)

Type of dysphagia (for solids fluids/ intermittent or progressive/ precise or vague)

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12
Q

Odynophagia

A

Pain on swallowing

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13
Q

what is oesophageal perforation?

A

hole in the oesophagus

3 areas of anatomical constriction (more vulnerable areas)

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14
Q

What is Boerhaave’s

A

sudden increase in intra-oesophageal pressure (vomit against closed glottis)

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15
Q

which foreign bodies cause a oesophageal perforation?

A

sharp objects
disk batteries (cause elctrical burns)
magnets
acid/ alkali

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16
Q

Trauma in the neck oesophageal perforation presentation?

A

dysphagia
haematemesis
surgical empysema
blood in saliva

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17
Q

what is GORD

A

acid from the stomach leaks up into the oesophagus

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18
Q

what does the antrum produce

A

gastrin

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19
Q

oesophageal perforation initial management?

A

IV fluids
Broad spectrum Antibiotics
Nil by mouth

20
Q

oesophageal definitive management?

A

conservative management with covered metal stent

21
Q

Protective mechanisms against reflux in the stomach

A

LOS usually closed as a barrier against reflux

22
Q

what contributes to increasing LOS reflux

A

acetylcholine
hormones
protein-rich food
histamine

23
Q

what contributes to decreasing LOS reflux

A

beta adrenergic agonists
dopamine
acid gastric juice
smoking

24
Q

Protective mechanism following reflux

A

volume clearance - oesophageal peristalsis reflex
pH clearance - saliva
epithelium - barrier properties

25
Causes of failure of protective mechanism
decreased vol clearance (abnormal peril-stasis) Slowed ph clearance ( not producing enough saliva) Smoking - decrease buffering capacity of saliva
26
Sliding hiatus hernia mechanism
gastro- oesophageal junction, and part of the stomach protrude into the chest
27
Rolling hiatus hernia
part of the stomach pushes up through the hole in the diaphragm next to the oesophagus (portion of stomach slips up the side)
28
Mechanism to repair epothelial defects
migration gap closed by cell growth acute wound healing
29
what do the body and fundus produce
mucus, HCl, pepsinogen
30
what is erosive + haemorrhagic gastritis
acute ulcer - gastric bleeding + perforation
31
what is nonerosive, chronic active gastritis
variety of histologic abnormalities that are mainly the result of Helicobacter pylori infection
32
what is atrophic gastritis
chronic inflammation of the gastric mucosa with loss of the gastric glandular cells and replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue
33
reactive gastritis
long-term contact with substances that irritate the stomach lining
34
Cause of erosive gastritis
NSAIDS multi-organ failure trauma ischaemia
35
what is reflux
passive return of gastroduodenal contents to the mouth
36
Mechanism to repair epithelial defects
migration - adjacent epithelial cells flatten to close gap gap closed by cell growth acute wound healing - epithelial closure by restitution + cell division
37
Why do you get ulcers
increased chemical aggression (anything that increases gastric juice secretion) barrier function disturbed (h. pylori)
38
what causes secondary hypermotility
chagas' disease protozoa infection amyloid/ sarcoma/ eosinophilic oesophagitis
39
what is the onset of hypermotility
insidious onset - symptoms for years prior to seeking help/ risk of oesophageal cancer increased 28 fold
40
how is hypermotility treated
PD - pneumatic dilatation (balloon inserted + inflated to resume flow) 90% of patients respond initially but many relapse
41
how is hyper-motility treated
PD - pneumatic dilatation (balloon inserted + inflated to resume flow) 90% of patients respond initially but many relapse
42
what is heller's myotomy
continuous myotomy performed for 6cm on oesophagus + 3cm onto stomach
43
dor fundoplication
anterior fundus folded over oesophagus + sutured to right side of myotomy
44
what is scleroderma
autoimmune hypomotility disease
45
what is the cause of scleroderma
early stages - due to neuronal defects + atrophy of smooth muscle of oesophagus
46
what is disordered coordination
incoordinate contractions which lead to dysphagia + chest pain marked hypertrophy of circular muscle
47
what are the causes of oesophageal perforation
cancer, foreign body, physiological dysfunction