Upper GI problems Flashcards
What is reflux oesophagitis?
Inflammation of the lining of the oesophagus often due to acid reflux
What are the symptoms of GORD?
Retrosternal pain relieved by eating Dysphagia Odynophagia Sour taste in mouth Bad breath Bloating Nausea Vomiting Gum disease Persistent cough
Why is GORD worse in asthma patients?
Acid reflux can irritate the airways too
Give 4 causes of GORD
Oesophageal laxity Hiatus hernia Smoking Pregnancy Obesity Certain foods NSAIDs
Give 3 conservative ways to manage GORD
Eat smaller meals Lose weight Reduce anxiety Sit upright Stop smoking Reduce alcohol Avoid trigger foods
How can GORD be managed conservatively?
Antacids
PPI (Omeprazole, Lansoprazole)
H2 antagonist (Ranitidine, Cimetidine)
What is a laparoscopic nissen fundoplication?
Keyhole surgery to tighten the oesophageal sphincter via wrapping the cardia of the stomach around the gastrooesophageal junction.
Give 3 complications of GORD
Oesophageal ulcers
Oesophageal strictures
Barrett’s oesophagus
Oesophageal cancers
What is Barrett’s oesophagus?
Stratified squamous epithelium converts to a simple columnar epithelium to cope with excess acid in lower oesophagus.
What are the symptoms of Barrett’s oesophagus?
Severe GORD symptoms New-onset asthma Chronic cough Bronchitis Sore throat Dysphagia (oesophageal ulcers and strictures)
How is Barrett’s oesophagus diagnosed?
Endoscopy and biopsy
How is Barrett’s oesophagus treated?
Cannot be reversed
Conservative management (same as GORD)
PPI
H2 antagonists
How often are Barrett’s oesophagus patients screened for oesophageal cancer?
Endoscopy between every 3 months and every 3 years depending on grade
What is dysplasia?
Presence of abnormal cells within a tissue which often precedes a cancer
What are the 2 types of oesophageal cancer?
Squamous cell carcinoma
Adenocarcinoma
Give the 2 main causes of oesophageal adenocarcinoma
GORD
Barrett’s oesophagus
Give the 2 main causes of oesophageal squamous cell carcinoma
Achalasia
Coeliac disease
Give 5 symptoms of oesophageal cancer
Dysphagia Heartburn Vomiting after eating Weight loss Loss of appetite Epigastric pain
How is oesophageal cancer diagnosed?
Endoscopy
Barium swallow
Staging CT
PET scan
What is an oesophagectomy?
Removal of part or all of the oesophagus.
What is an Ivor-Lewis procedure?
Removal of all of the lower oesophagus, stomach pulled up into chest and anastomosed to the upper oesophagus.